Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52299 | Cantuzumab ravtansine (IMGN242; huC242-DM4) | 868747-45-9 | Cantuzumab ravtansine (IMGN242; huC242-DM4) is an ADC consisting of a humanized monoclonal antibody (mAb), huC242, covalently linked to DM4 via a disulfide bond. |
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V17952 | Cevipabulin | 849550-05-6 | Cevipabulin (formerly D-06576;TTI-237) is a triazolopyrimidine based microtubule targeting agent/tubulin inhibitor with potential antitumor activity. |
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V55261 | cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) | 94608-23-8 | Cis-trismethoxy resveratrol is a potent antimitotic active that can inhibit tubulin polymerization with IC50 of 4 μM. |
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V3117 | Colchicine | 64-86-8 | Colchicine (Colchicina; Condylon; Colsaloid; Colchicinum) is a mitotic/tubulin inhibitor that inhibits microtubule polymerization (also called microtubule disrupting agent or tubulin inhibitor) with potential anticancer and anti-inflammatory effects. |
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V51024 | Combretastatin A-1 | 109971-63-3 | Combretastatin A-1 is a novel inhibitor of microtubule polymerization that attaches itself to tubulin's colchicine-binding site. |
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V18816 | Crolibulin | 1000852-17-4 | Crolibulin, formerly known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. |
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V55251 | Curvulin | 19054-27-4 | Curvulin is a plant toxin that can inhibit microtubule assembly and iNOS expression. |
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V51233 | Cys-McMMAF | 1160590-05-5 | Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated via a maleimidocaproyl linker to the microtubule-disturbing MMAF . |
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V2890 | D-64131 | 74588-78-6 | D-64131, an aroylindole analog, is a novel, oral and potent inhibitor of tubulin polymerization. |
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V19560 | Demecolcine | 477-30-5 | Demecolcine (Colcemid), acolchicine analog, is a potent microtubule polymerization inhibitor/ mitoticinhibitor /depolymerizing anti-tubulin agent with anticancer activity. |
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V32040 | Deoxypodophyllotoxin | 19186-35-7 | Deoxypodophyllotoxin (DPT), an analogue of podophyllotoxin, is a lignan extracted from Anthriscus sylvestris with potent antimitotic and antiviral properties. |
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V52179 | Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) | 156312-07-1 | Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizer. |
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V20123 | DM1-SMe | 138148-68-2 | DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. |
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V83221 | Dolastatin 10 trifluoroacetate | 2342568-65-2 | Dolastatin 10 trifluoroacetate is a potent tubulin polymerization inhibitor with anticancer activity. |
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V55258 | Dolastatinol | 2759918-83-5 | Dolastatinol is a synthetic analog of dolastatin 10, a low nanomolar inhibitor of tubulin polymerization. |
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V83366 | E7130 | ||
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V84953 | EGFR/microtubule-IN-1 | 1970269-96-5 | |
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V2901 | ELR510444 | 1233948-35-0 | ELR-510444 is a novel and potent inhibitor of microtubule polymeirzation (also called microtubule disruptor or mitotic inhibitor) with potential antivascular effects and in vivo antitumor efficacy, it can cause a loss of cellular microtubules and the formation of aberrant mitotic spindles which lead to mitotic arrest and apoptosis of cancer cells. |
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V3524 | Epothilone D (KOS 862) | 189453-10-9 | Epothilone D (formerly known as KOS 862; KOS-862; desoxyepothilone B) is a potent microtubule stabilizing agent that has high anticancer activity. |
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V55257 | ER degrader 7 | 2922929-63-1 | ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. |
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