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Microtubule(Tubulin)

Microtubule(Tubulin)

Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.

Microtubule(Tubulin) related products

Structure Cat No. Product Name CAS No. Product Description
Anticancer agent 98 V34998 Anticancer agent 98 2857070-72-3 Anticancer agent 98 (compound 12k) is a tubulin polymerization inhibitor (Kd=16.9 μM).
Antiproliferative agent-14 V34829 Antiproliferative agent-14 1885900-35-5 antiproliferation agent-14 (compound 3b) is a potent inhibitor of tubulin polymerization with IC50 of 3.41 μM.
Antiproliferative agent-23 V78056 Antiproliferative agent-23 antiproliferation agent-23 is a microtubule destabilizing agent (MDA) that effectively interferes with the tubulin-microtubule system.
Antiproliferative agent-30 V55250 Antiproliferative agent-30 2713553-88-7 antiproliferation agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1.
Antitubulin agent 1 V79807 Antitubulin agent 1 Antitubulin agents-1 is an antitubulin agent that induces disruption of microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation.
Antitumor agent-138 V83574 Antitumor agent-138 2975168-22-8
Antitumor agent-155 V88701 Antitumor agent-155 Antitumor agent-155 (Compound 13) inhibits microtubule polymerization and induces cell autophagy and apoptosis.
Antitumor agent-164 V88697 Antitumor agent-164 2757188-21-7 Antitumor agent-164 (compound 60c) is a colchicine binding site inhibitor (CBSI) with efficacy in taxane-sensitive TNBC.
Antitumor agent-168 V101221 Antitumor agent-168 Antineoplastic agent-168 (compound 21b) disrupts the microtubule network in tumor cells, leading to G2/M cell cycle arrest and inducing apoptosis.
APL-1081 V104595 APL-1081 2921735-80-8 APL-1081 (Mal-Exo-EVC-MMAE) is part of an antibody-conjugated active molecule ADC.
Auristatin E V5180 Auristatin E 160800-57-7 Auristatin E,a synthetic analog of dolastatin 10, is a novel and highly cytotoxic tubulin inhibitor with antitumor activity; it is a MMAE analog and cytotoxin used in Antibody-drug conjugates.
Bis-ANS dipotassium V52340 Bis-ANS dipotassium 65664-81-5 Bis-ANS dipotassium is a protein fluorescent probe.
BNC-105 V13004 BNC-105 945771-74-4 BNC105 is a potentbenzofuran-basedtubulin polymerization inhibitor and also avascular disrupting agent (VDA) prodrug with potential anti-vascular and anticancer activities.
BNZ-111 V94978 BNZ-111 3022361-60-7 BNZ-111 is an orally available tubulin inhibitor with anti-tumor activity.
BP-M345 V103501 BP-M345 1360119-00-1 BP-M345 (compound 5) is a potent cancer cell-targeted antiproliferative agent with low toxicity to non-tumor cells.
Breast cancer targeting peptide 18–4 V106250 Breast cancer targeting peptide 18–4 1332850-08-4 Breast cancer targeting peptide 18-4 is a keratin 1 (KRT1) receptor targeting peptide with a Kd of 0.98 μM.
BTB-1 V3229 BTB-1 86030-08-2 BTB-1 is a novel, potent and the first small molecule inhibitor of the mitotic motor protein Kif18A.
CDK2/4-IN-1 V88615 CDK2/4-IN-1 CDK2/4-IN-1 (compound B-4a) is a CDK2/4 inhibitor and also a tubulin polymerization inhibitor.
Cemadotin hydrochloride V96733 Cemadotin hydrochloride 172837-41-1 Cemadotin hydrochloride (LU103793), a water-soluble synthetic dolastatin 15 analog, inhibits cell proliferation in vitro and growth of mouse tumor xenografts.
Cetuximab MMAE V105323 Cetuximab MMAE Cetuximab MMAE is an antibody-drug conjugate (ADC) that is an anti-EGFR humanized monoclonal antibody conjugated to VcMMAE.
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