Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V40995 | PM050489 | 960210-97-3 | PM050489 is a potent polyketide microtubule/tubulin inhibitor extracted from the Madagascar sponge Lithoplocamia lithistoides. |
|
V79576 | Podofilox-d6 (podophyllotoxin-d6) | Podofilox-d6 is the deuterium labelled form of Podofilox. | |
|
V60090 | Podophyllotoxone | 477-49-6 | Podophyllotoxone is extracted from the roots of Illustrations anise and has anti-cancer effect. |
|
V85074 | PROTAC tubulin-Degrader-1 | ||
|
V86017 | S-72 | 2446799-14-8 | |
|
V37753 | S516 | 1016543-77-3 | S516 (Compound 22) is the bioactive metabolite of CKD-516 and a potent tubulin polymerization inhibitor (antagonist) with IC50 of 4.29 μM. |
|
V37480 | SB26019 | 1233078-90-4 | SB26019 is a potent anti-neuroinflammatory agent. |
|
V35266 | Sovilnesib (AMG 650) | 2410796-79-9 | Sovilnesib (AMG 650) is an orally bioavailable inhibitor of kinesin-like protein KIF18A with IC50 of 0.071 μM. |
|
V3749 | SSE15206 | 1370046-40-4 | SSE15206 is a mitotic inhibitor, specifically, a microtubule depolymerizing agent that can overcome multidrug resistance. |
|
V79817 | SSE1806 | SSE1806 is an analogue of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor (antagonist) with significant anticancer and antiproliferation activities. | |
|
V55252 | Sudocetaxel | 1234218-62-2 | Sudocetaxel is a microtubule depolymerization inhibitor for pH-sensitive docetaxel release. |
|
V54251 | T-peptide | 2022956-62-1 | T-peptide is a Tuftsin analog that may be utilized to study human immunodeficiency virus (HIV) infection. |
|
V75811 | Taccalonolide AJ | 2230777-09-8 | Taccalonolide AJ is a semi-synthetic compound with cellular microtubule stabilizing activity. |
|
V7586 | Taltobulin | 228266-40-8 | Taltobulin (HTI-286; SPA-110), an analog of the natural tripeptide hemiasterlin, is a tubulin inhibitor with anticancer activity. |
|
V76455 | Taltobulin hydrochloride (HTI-286 hydrochloride; SPA-110 hydrochloride) | Taltobulin HCl (HTI-286 HCl) is a synthetic tripeptide cysteine analogue. | |
|
V31385 | Taltobulin trifluoroacetate | 228266-41-9 | Taltobulin trifluoroacetate (HTI-286; HTI286; SPA-110; SPA110), the trifluoroacetate salt of taltobulin, is an nalogue of Hemiasterlin, acting as a tubulin inhibitor and used as an ADC cytotoxin (warhead). |
|
V84139 | TAM557 | 1802499-20-2 | |
|
V35220 | Tau tracer 1 | 2173353-53-0 | Tau tracer 1 is a Tau tracer used for imaging Tau protein aggregates. |
|
V35219 | Tau tracer 2 (Pl-2620) | 2173361-80-1 | Tau tracer 2 (Pl-2620) is a Tau tracer used for imaging Tau protein aggregates. |
|
V55255 | Taxinine B (Taxinin B) | 18457-44-8 | Taxinine B is a taxane extracted from the Japanese yew Taxus Cuspid. |
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