Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52604 | Clofibric acid-d4 (Chlorofibric acid-d4) | 1184991-14-7 | Clofibric acid-d4 is the deuterated form of Clofibric acid. |
|
V54370 | CRX000227 | 686769-92-6 | CRX000227 is a PPAR modulator. |
|
V51339 | DS-6930 | 1242328-82-0 | DS-6930 is a novel agonist of PPARγ, with an EC50 of 41 nM. DS-6930 has the potential to significantly lower plasma glucose (PG) while having fewer negative effects related to PPARγ than Rosiglitazone. |
|
V52152 | DSO-5a | 2195411-63-1 | DSO-5a is a specific, orally bioactive BB3 agonist. |
|
V106986 | E17241 | 1060968-92-4 | E17241 is an inducer of ABCA1 expression and increases the protein level of ABCA1 in RAW 264.7 macrophages. |
|
V3186 | Elafibranor | 923978-27-2 | Elafibranor (formerly GFT505) is a dual agonist of the PPARα/δ (peroxisome proliferator-activated receptor-α and -δ) with EC50 values of 45 and 175 nM, respectively. |
|
V3544 | Endurobol (GW501516; GSK-516) | 317318-70-0 | GW 501516 (also known as endurobol; GW-501516; GSK-516) is a novel and potent PPARδ agonist with an EC50 of 1.1 nM. |
|
V55720 | Foenumoside B | 877661-00-2 | Foenumoside B is a triterpene saponin extracted from Lysimachia foenum-graecum. |
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V54438 | FTX-6746 | 2829349-96-2 | FTX-6746 is an orally bioactive PPARG inhibitor. |
|
V67761 | FX-909 | 2924573-90-8 | FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. |
|
V54439 | Gancaonin L | 129145-50-2 | Gancaonin L is an isoflavone extracted from Glycyrrhiza glabra. |
|
V52622 | Gemfibrozil-d6 (CI-719-d6) | 1184986-45-5 | Gemfibrozil-d6 is the deuterium labelled form of Gemfibrozil. |
|
V3035 | GSK0660 | 1014691-61-2 | GSK0660 is a potent and selective antagonist of PPARβ and PPARδ with IC50values of both 155 nM, it has little or no activity on PPARα and PPARγ with IC50values of >10 μM. |
|
V60007 | GW-590735 | 343321-96-0 | GW 590735 is a potent and specific PPARα agonist. |
|
V4928 | GW-7647 | 265129-71-3 | GW7647 (GW-7647) is a novel, selective and potent agonist of human and murine PPARα4 with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively. |
|
V4936 | GW1929 | 196808-24-9 | GW1929 is a novel, potent and selective PPAR-γ agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. |
|
V51335 | GW9662-d5 | 2117730-84-2 | GW9662-d5, deuterium labeled GW9662. GW9662 is a novel antagonist of PPARγ that exhibits selectivity over PPARα and PPARδ of 10 and 1000 times, respectively, at an IC50 of 3.3 nM. |
|
V5144 | Indeglitazar (PPM 204 and PLX 204) | 835619-41-5 | Indeglitazar (formerly PPM-204 and PLX-204) is a novel, potent and orally bioavailable peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ). |
|
V67759 | KD-3010 | 934760-92-6 | KD-3010 is an orally bioactive, potent and specific PPARδ agonist. |
|
V31420 | LJ570 | 2252488-69-8 | LJ570 is a dual PPARα/PPARγ agonist with EC50 of 1.05 and 0.12 μM. |
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