PPAR

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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PPAR

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.

PPAR related products

Cat No.	Product Name	CAS No.	Product Description
V52152	DSO-5a	2195411-63-1	DSO-5a is a specific, orally bioactive BB3 agonist.
V3186	Elafibranor	923978-27-2	Elafibranor (formerly GFT505) is a dual agonist of the PPARα/δ (peroxisome proliferator-activated receptor-α and -δ) with EC50 values of 45 and 175 nM, respectively.
V51333	Fenofibric acid-d6	1092484-69-9	Fenofibric acid-d6 (FNF acid-d6), deuterium labeled Fenofibric acid.
V55720	Foenumoside B	877661-00-2	Foenumoside B is a triterpene saponin extracted from Lysimachia foenum-graecum.
V54438	FTX-6746	2829349-96-2	FTX-6746 is an orally bioactive PPARG inhibitor.
V67761	FX-909	2924573-90-8	FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist.
V51061	FX-909		FX-909 is an inverse agonist of the covalent peroxisome proliferator-activated receptor gamma (PPARG).
V54439	Gancaonin L	129145-50-2	Gancaonin L is an isoflavone extracted from Glycyrrhiza glabra.
V52622	Gemfibrozil-d6 (CI-719-d6)	1184986-45-5	Gemfibrozil-d6 is the deuterium labelled form of Gemfibrozil.
V3035	GSK0660	1014691-61-2	GSK0660 is a potent and selective antagonist of PPARβ and PPARδ with IC50values of both 155 nM, it has little or no activity on PPARα and PPARγ with IC50values of >10 μM.
V3544	GW 501516	317318-70-0	GW 501516 (also known as endurobol; GW-501516; GSK-516) is a novel and potent PPARδ agonist with an EC50 of 1.1 nM.
V60007	GW-590735	343321-96-0	GW 590735 is a potent and specific PPARα agonist.
V4928	GW-7647	265129-71-3	GW7647 (GW-7647) is a novel, selective and potent agonist of human and murine PPARα4 with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively.
V4936	GW1929	196808-24-9	GW1929 is a novel, potent and selective PPAR-γ agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively.
V51335	GW9662-d5	2117730-84-2	GW9662-d5, deuterium labeled GW9662. GW9662 is a novel antagonist of PPARγ that exhibits selectivity over PPARα and PPARδ of 10 and 1000 times, respectively, at an IC50 of 3.3 nM.
V5144	Indeglitazar (PPM 204 and PLX 204)	835619-41-5	Indeglitazar (formerly PPM-204 and PLX-204) is a novel, potent and orally bioavailable peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ).
V67759	KD-3010	934760-92-6	KD-3010 is an orally bioactive, potent and specific PPARδ agonist.
V3029	Lanifibranor	927961-18-0	Lanifibranor (formerly named as IVA-337) is a novel, potent and well balanced agonist of the pan-peroxisome proliferator-activated receptors (PPAR) with excellent safetyprofiles and with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively.
V31420	LJ570	2252488-69-8	LJ570 is a dual PPARα/PPARγ agonist with EC50 of 1.05 and 0.12 μM.
V24880	MA-0204	2095128-17-7	MA-0204 is a highly potent and selective PPARd modulator (PPARδ EC50 = 0.4 nM; PPARalpha, EC50 == 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation.