Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptor superfamily ligand-activated transcription factors that include the following three subtypes: PPAR, PPAR, and PPAR/. Higher organisms' cellular differentiation, development, metabolism (carbohydrate, lipid, and protein), as well as tumorigenesis, are all crucially regulated by PPARs. All PPARs bind to particular regions of the target genes' DNA through heterodimerization with the retinoid X receptor (RXR). Triglyceride levels are reduced and energy homeostasis is regulated when PPAR- is activated. PPAR- activation improves the metabolism of glucose, whereas PPAR-/ activation improves the metabolism of fatty acids.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51328 | Mavodelpar sodium (REN-001; HPP-593) | 1604815-32-8 | Mavodelpar (REN001) is a novel and potent agonist of PPARδ. |
|
V51350 | Mesalamine impurity P | 887256-40-8 | Mesalamine impurity P is a mesalamine impurity . |
|
V51346 | Methyl oleanonate | 1721-58-0 | Methyl oleanonate is a naturally occurring triterpene PPARγ agonist that was isolated from the Pistacia lentiscus var. Chia species. |
|
V51352 | MSDC-0602K (Azemiglitazone potassium) | 1314533-27-1 | MSDC-0602K(Azemiglitazone potassium) is a thiazolidinedione (Ps-TZD) that spares PPARγ; its IC50 value is 18.25 μM. |
|
V3520 | Muraglitazar (BMS298585) | 331741-94-7 | Muraglitazar (BMS-298585; BMS298585) is a novel, potent and selective Peroxime Proliferator Activated (PPAR) α/γ dual agonist with glucose- and lipid-lowering activities. |
|
V51344 | Oleoyl Ethanolamide-d2 | 1245477-09-1 | Oleoylethanolamide-d2 is the labeled Oleoylethanolamide, deuterium. |
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V56571 | Palmitelaidic acid-d13 (palmitate d13) | 2692623-91-7 | Palmitelaidic acid-d13 is the deuterated form of Palmitelaidic Acid. |
|
V51336 | Pioglitazone-d4 (alkyl) | 1134163-31-7 | Pioglitazone-d4 (alkyl) (U 72107-d4 (alkyl)), deuterium labeled Pioglitazone. |
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V51327 | PPARα/γ agonist 2 | 2213365-56-9 | PPARα/γ agonist 2 is a novel and potent PPARα full agonist and PPARγ partial agonist. |
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V84476 | PPARα/γ agonist 3 | ||
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V85089 | PPARα/δ agonist 2 | ||
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V67758 | PPARαagonist 1 | 2361366-85-8 | PPARα agonist 1 is a potent, complete PPARα agonist. |
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V83558 | PPARγ agonist 10 | 2445990-92-9 | |
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V67760 | PPARγ agonist 8 | 1049800-41-0 | PPARγ agonist 8 is an agonist of PPARγ. |
|
V86147 | PPARγ agonist 9 | 474329-47-0 | |
|
V85530 | PPARγ modulator-1 | 1415321-54-8 | |
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V67762 | PPARγ phosphorylation inhibitor 1 | 2882975-84-8 | PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binder with IC50 of 24 nM. |
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V67763 | PPARγ-IN-2 | 2682078-97-1 | PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. |
|
V80219 | PPARγ/GR modulator 1 | PPARγ/GR modulator 1 is an orally bioactive dual-action agonist of PPARγ and glucocorticoid receptor (GR) with Kis of 3.3 and 33.6 μM, respectively. | |
|
V79264 | Pparδagonist 5 | Pparδ agonist 5, an orally bioactive and selective PPARδ agonist (EC50=0.335 μM), is more selective than GW0742. |
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