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Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. Ras is the representative member of the Ras superfamily, a group of proteins that all share a common 3D structure and control a variety of cell behaviors. Incoming signals that activate Ras then activate other proteins, which in turn activate genes necessary for cell growth, differentiation, and survival. Ras proteins that are permanently activated can therefore be produced as a result of ras gene mutations.Even in the absence of incoming signals, this may result in unintended and excessive signaling within the cell. Overactive Ras signaling can ultimately result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the 3 Ras genes (HRAS, KRAS, and NRAS), and Ras inhibitors are being researched as a potential treatment for cancer and other conditions characterized by Ras overexpression.

Ras related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Oxanthromicin V87119 (+)-Oxanthromicin 1616622-08-2 (+)-Oxanthromicin (Compound 1) can mislocalize oncogenic mutant K-Ras from the plasma membrane in intact Madin-Darby canine kidney (MDCK) cells, thereby exerting antitumor activity.
(RS)-G12Di-1 V89591 (RS)-G12Di-1 (RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.
(S)-JDQ-443 ((S)-NVP-JDQ443) V51415 (S)-JDQ-443 ((S)-NVP-JDQ443) 2653994-10-4 (S)-JDQ-443 is an isomer of JDQ-443 .
2-羟基-1-萘甲醛 V51476 CFL-137 708-06-5 CFL-137 is a selective KRasG12C inhibitor.
4,6-二氯靛红 V51475 CFL-120 18711-15-4 CFL-120 is a selective KRasG12C inhibitor.
8-CPT-2'-O-Me-cAMP V87108 8-CPT-2'-O-Me-cAMP 510774-50-2 8-CPT-2'-O-Me-cAMP is a Rap1 activator.
8-pHPT-2'-O-Me-cAMP V87118 8-pHPT-2'-O-Me-cAMP 612513-15-2 8-pHPT-2'-O-Me-cAMP is a cAMP analog and an Epac agonist.
ADT-007 V86758 ADT-007 1945941-09-2 ADT-007 is a potent, orally active pan-RAS inhibitor with strong anticancer effects.
AM-001 V93209 AM-001 340817-81-4 AM-001 is a noncompetitive Epac1 inhibitor that blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells.
Anticancer agent 207 V87112 Anticancer agent 207 Anticancer agent 207 (compound 10b) is a potent anticancer agent.
Antineoplaston A 10 V11400 Antineoplaston A 10 91531-30-5 Antineoplaston A10 exists naturally in the human body and is an inhibitor (blocker/antagonist) of Ras.
Antitumor compound 5a V51547 Antitumor compound 5a 2907704-65-6 Antitumor compound 5a, has an IC50 value of 2.62 µM, meaning that it inhibits MCF-7 breast cancer cells.
ARN22089 V83594 ARN22089 2248691-29-2
ARN25062 V93277 ARN25062 3036492-85-7 ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity.
ARS-1323-alkyne V51473 ARS-1323-alkyne 2436544-27-1 ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, a conformationally specific chemical reporter of the KRASG12C nucleotide state in living cells, is a switch-II pocket (S-IIP) inhibitor.
ARS-2102 V51452 ARS-2102 2098509-21-6 ARS-2102 is a potent covalent KRAS G12C inhibitor for cancer research.
ASP-2453 V51458 ASP-2453 2241719-73-1 ASP2453 is a novel and covalent inhibitor of KRAS G12C.
ASP6918 V83369 ASP6918
AZD4747 V77220 AZD4747 2489226-14-2 AZD4747 is a selective, BBB (blood-brain barrier) permeable/penetrable inhibitor of the mutant GTPase KRASG12C.
BBO-8520 V86759 BBO-8520 2893809-51-1 BBO-8520 is a direct small molecule covalent inhibitor targeting KRASG12C, with high oral availability, and has both KRASG12C (OFF) inhibitor properties and the effect of blocking KRAS G12C (ON) signaling.
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