Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3828 | Ellipticine | 519-23-3 | Ellipticine, originally identified as a natural product, is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP). |
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V3829 | Ellipticine HCl | 5081-48-1 | Ellipticine HCl, originally identified as a natural product, is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP). |
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V55709 | Elomotecan hydrochloride (BN 80927) | 220997-99-9 | Elomotecan HCl (BN 80927) is a potent inhibitor of topoisomerase I and II. |
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V30119 | Epirubicin (4'-Epidoxorubicin) | 56420-45-2 | Epirubicin (IMI 28; IMI-28;4-epidoxorubicin; epiADR; epidoxorubicin; Ellence; Pharmorubicin PFS) is ananthracycline-basedanticancer agentused for chemotherapy. |
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V51544 | erythro-Austrobailignan-6 | 114127-24-1 | Erythro-Austrobailignan-6 is a novel, potent and orally bioactive anti-cancer agent. |
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V55710 | Exatecan Intermediate 5 (N,N'-(3-fluoro-4-methyl-8-oxo-5,6,7,8-tetralin-1,7-diyl)diethylamide) | 143655-70-3 | Exatecan Intermediate 5 is an intermediate of Exatecan . |
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V55711 | Exatecan Intermediate 6 (N-(3-fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide) | 143655-58-7 | Exatecan Intermediate 6 is an intermediate of Exatecan . |
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V55712 | Exatecan Intermediate 7 | 182182-32-7 | Exatecan Intermediate 7 is an intermediate of Exatecan . |
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V55713 | Exatecan-d5 mesylate (DX8951f-d5; Exatecan-d5 (mesylate); Deuterated labeled Exatecan (mesylate)) | 2819276-88-3 | Exatecan-d5 (mesylate) is the deuterium labelled form of Exatecan mesylate. |
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V21554 | GENZ-644282 | 529488-28-6 | Genz-644282, formerly known as SAR402674, is a novel, potent and non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. |
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V55714 | Guajadial C | 1529775-02-7 | Guajadial C is a Top1 catalytic inhibitor that delays DNA damage mediated by Top1 toxicity. |
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V51990 | Hippeastrine (Hippeastrine) | 477-17-8 | Hippeastrine is an active alkaloid with good dose-dependent inhibition of topoisomerase I Top I with IC50 of 7.25 μg/mL. |
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V55715 | Huanglongmycin N | 2881024-09-3 | Huanglongmycin N is a DNA topoisomerase I inhibitor (EC50 = 14 μM). |
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V55716 | ICRF-196 | 21416-68-2 | ICRF-196 is a racemic mixture (racemate) of the (S,S)- and (R,R)-isomers of ICRF-193 . |
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V78288 | ikB | AuM1Gly? is a topoisomerase I (topoisomerase I< b>) inhibitor. | |
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V5157 | Indotecan (LMP-400; NSC-724998) | 915303-09-2 | Indotecan (LMP400; NSC724998) is a novel, potent and selective topoisomerase I inhibitor with IC50values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. |
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V9834 | Intoplicine dimesylate (RP 60475 dimesylate) | 133711-99-6 | Intoplicine (RP 60475) dimesylate, an antitumor analogue of the 7H benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. |
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V85840 | LMP517 (NSC 781517) | 1883730-99-1 | |
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V5185 | LMP744 (MJ-III65; NSC706744) | 308246-52-8 | LMP744 (Mj-III-65, NSC-706744) is a novel and potent DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. |
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V54363 | Luotonin A | 205989-12-4 | Luotonin A is an antiviral and antiphytopathogenic fungus agent. |
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