Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V84421 | MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 | 1241391-14-9 | |
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V52597 | Mitoxantrone-d8 (Mitozantrone-d8; NSC 301739-d8) | 1189974-82-0 | Mitoxantrone-d8 is the deuterium labelled form of Mitoxantrone. |
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V55717 | NBTIs-IN-6 | 2422893-97-6 | NBTIs-IN-6 is a bacterial topoisomerase inhibitor (antagonist) with certain anti-bacterial effect. |
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V85415 | P5(PEG24)-VC-PAB-exatecan | 2928571-43-9 | |
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V83556 | Pericosine A ((+)-Pericosine A) | 200335-68-8 | |
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V28652 | Pirarubicin Hydrochloride (THP) | 95343-20-7 | icin hydrochloride (THP), an analogue of anthracycline, is an anti-neoplastic doxorubicin which acts as a topoisomerase II inhibitor, and is used for treatment of various cancers, in particular, solid tumors. |
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V2893 | SW044248 | 522650-83-5 | SW044248 is a novel, potent and selective Topoisomerase I inhibitor that was identified through a screen for chemicals selectively toxic for non-small cell lung cancer (NSCLC) cell lines. |
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V81598 | Topoisomerase I inhibitor 10 | Topoisomerase I inhibitor 10 (compound 13) is a leishmanial topoisomerase IB inhibitor. | |
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V85715 | Topoisomerase I inhibitor 12 | ||
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V85313 | Topoisomerase I inhibitor 13 | ||
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V34714 | Topoisomerase I inhibitor 8 | 210346-40-0 | Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. |
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V34713 | Topoisomerase II inhibitor 13 | 451515-89-2 | Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. |
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V84251 | Topoisomerase II inhibitor 17 | ||
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V85524 | Topoisomerase II/EGFR-IN-1 | ||
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V78891 | Topoisomerase IIα-IN-5 | Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. | |
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V81599 | Topoisomerase IIα-IN-6 | Topoisomerase IIα-IN-6 (Compound 47d) is a DNA topoisomerase IIα/β inhibitor. | |
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V81600 | Topoisomerase IIα-IN-7 | Topoisomerase IIα-IN-7 is an inhibitor (blocker/antagonist) of DNA topoisomerase IIα with IC50 of 7.7 µM. | |
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V85729 | Topoisomerase IIα-IN-8 | 1251578-67-2 | |
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V55718 | Topoisomerase inhibitor 2 | 2713986-17-3 | Topoisomerase inhibitor 2(18C) is a bacterial topoisomerase inhibitor that displays strong broad spectrum (a wide range) activity against multidrug-resistant Gram-negative (Gram-) bacteria. |
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V84958 | Topoisomerase inhibitor 3 |
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