Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V88210 | Gatifloxacin-d4 hydrochloride | 1189946-71-1 | Gatifloxacin-d4 (AM-1155-d4; BMS-206584-d4; PD135432-d4) hydrochloride is deuterated Gatifloxacin (hydrochloride) . |
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V21554 | GENZ-644282 | 529488-28-6 | Genz-644282, formerly known as SAR402674, is a novel, potent and non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. |
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V94352 | Gepotidacin hydrochloride | 1075235-46-9 | Gepotin hydrochloride is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. |
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V99627 | Gepotidacin mesylate hydrate | 1624306-20-2 | Gepotin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. |
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V88376 | Gly-Gly-Phe-Gly-NH-O-CO-Exatecan hydrochloride | Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is a linker Gly-Gly-Phe-Gly-NH-O-CO and Exatecan, which can be used to prepare antibody-drug conjugates. | |
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V88377 | Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide | 2750623-07-3 | Gly-Mal-GGFG-Deruxtecan 2-hydroxy propionamide is a camptothecin derivative that can be used as a drug linker for ADCs. |
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V55714 | Guajadial C | 1529775-02-7 | Guajadial C is a Top1 catalytic inhibitor that delays DNA damage mediated by Top1 toxicity. |
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V51990 | Hippeastrine (Hippeastrine) | 477-17-8 | Hippeastrine is an active alkaloid with good dose-dependent inhibition of topoisomerase I Top I with IC50 of 7.25 μg/mL. |
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V102533 | HU 331 | 137252-25-6 | HU 331 (HU 331) is a highly specific topoisomerase II inhibitor with anticancer activity. |
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V55715 | Huanglongmycin N | 2881024-09-3 | Huanglongmycin N is a DNA topoisomerase I inhibitor (EC50 = 14 μM). |
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V55716 | ICRF-196 | 21416-68-2 | ICRF-196 is a racemic mixture (racemate) of the (S,S)- and (R,R)-isomers of ICRF-193 . |
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V94217 | Indimitecan hydrochloride | 915303-04-7 | Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activity. |
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V5157 | Indotecan (LMP-400; NSC-724998) | 915303-09-2 | Indotecan (LMP400; NSC724998) is a novel, potent and selective topoisomerase I inhibitor with IC50values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. |
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V94309 | Indotecan hydrochloride | 1228035-68-4 | Indolecan hydrochloride is an indenoisoquinoline derivative and a potent inhibitor of topoisomerase I. |
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V9834 | Intoplicine dimesylate (RP 60475 dimesylate) | 133711-99-6 | Intoplicine (RP 60475) dimesylate, an antitumor analogue of the 7H benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. |
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V90550 | Irinotecan-d5 hydrochloride | 718612-73-8 | Irinotecan-d5 hydrochloride is a deuterated form of Irinotecan hydrochloride. |
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V107055 | Levofloxacin mesylate | 226578-51-4 | Levofloxacin mesylate is an oral antibiotic that is active against both Gram-positive and Gram-negative bacteria. |
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V85840 | LMP517 (NSC 781517) | 1883730-99-1 | |
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V5185 | LMP744 (MJ-III65; NSC706744) | 308246-52-8 | LMP744 (Mj-III-65, NSC-706744) is a novel and potent DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. |
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V54363 | Luotonin A | 205989-12-4 | Luotonin A is an antiviral and antiphytopathogenic fungus agent. |
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