RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52170 | DNA Gyrase-IN-8 | 2925308-76-3 | DNA Gyrase-IN-8 is a potent DNA gyrase inhibitor (antagonist) with IC50 of 8.45 µM. |
|
V55154 | DNA polymerase-IN-1 | 809234-33-1 | DNA polymerase-IN-1 (compound 2d) is an inhibitor of DNA polymerase that exhibits anti-proliferative activity against tumor cells, with an IC50 of 20.7 μM. |
|
V79186 | DNA polymerase-IN-2 | DNA polymerase-IN-2 (Compd 3c) is a coumarin analogue that displays inhibitory effect against Taq DNA polymerase with IC50 of 48.25 μM and may be utilized in proliferative disease study. | |
|
V55130 | DNA polymerase-IN-3 | 381689-75-4 | DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that can be used in proliferative disease research because it shows inhibitory activity against Taq DNA polymerase. |
|
V84499 | DNA relaxation-IN-1 | 2190506-29-5 | |
|
V52151 | DTP3 TFA | 2759216-46-9 | DTP3 TFA is a potent and specific inhibitor of GADD45β/MKK7. |
|
V53226 | dUTP trisodium (2'-Deoxyuridine-5'-triphosphate trisodium salt) | 102814-08-4 | dUTP trisodium is the raw material used for PCR amplification. |
|
V1432 | E3330 (APX-3330) | 136164-66-4 | E3330(E-3330; E 3330; APX-3330; APX 3330;APX3330)is a potent,orally bioactive and selective APE1 (Ref-1, AP endonuclease 1) inhibitor with potential antitumor activity. |
|
V53240 | EDTA dipotassium dihydrate (Ethylenediaminetetraacetic acid dipotassium dihydrate) | 25102-12-9 | EDTA (Ethylenediaminetetraacetic acid) dipotassium dihydrate is an anticoagulant that can chelate heavy metals and relieve toxicity. |
|
V53493 | Eesperamicin A1 | 99674-26-7 | Esperamicin A1 is a very potent antitumor antibiotic isolated from cultures of Actinobacterium verrucosum. |
|
V52139 | EFdA-TP | 950913-56-1 | EFdA-TP is a novel and selective nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP acts as a potent immediate or delayed chain terminator (ICT or DCT) to inhibit RT-catalyzed DNA synthesis. EFdA-TP inhibits HIV-1 RT through multiple mechanisms. |
|
V79247 | EFdA-TP tetraammonium | EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. | |
|
V52140 | EFdA-TP tetrasodium | 2883783-00-2 | EFdA-TP tetrasodium is a novel and selective nucleoside reverse transcriptase (RT) inhibitor. |
|
V79308 | Enhanced Taq DNA polymerase | Taq DNA polymerase is a thermostable DNA polymerase that may be utilized in PCR. | |
|
V20572 | Enocitabine | 55726-47-1 | Enocitabine (NSC-239336; BHAC; Sunrabin; Arabinoside) is a cytarabine analogue, cytosine analogue and DNA chain terminator approved as an anticancer drug for the treatment of acute myeloid leukemia. |
|
V29133 | Enoxacin hydrate (CI-919) | 84294-96-2 | Enoxacin (also known as AT-2266, CI919, Pd107779, NSC 629661)is an orally bioavailable, broad-spectrum antibacterial agent of thefluoroquinolone class. |
|
V30175 | Eriodictyol | 552-58-9 | Eriodictyol is a flavonoid obtained from Chinese herbal medicine and has antioxidant and anti~inflammatory effects. |
|
V52827 | Erythromycin-d3 (erythromycin-d3) | 959119-26-7 | Erythromycin-d3 is the deuterated form of Erythromycin. |
|
V55112 | FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) | 13018-54-7 | FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide. |
|
V1430 | Favipiravir (T-705) | 259793-96-9 | Favipiravir (formerly T-705; T705; T 705; Avigan),an approved antiviral drug used to treat influenza in Japan, is a selective RNA-dependent RNA polymerase inhibitor. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
