RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V34728 | Quinizarin (1,4-Dihydroxyanthraquinone; 1,4-Dihydroxyanthraquinone) | 81-64-1 | Quinizarin (1,4-Dihydroxyanthraquinone) is a part of anti-cancer active molecules such as Doxorubicin, Daunorubicin, Adriamycin, etc. |
|
V1473 | Raltitrexed (ZD1694） | 112887-68-0 | Raltitrexed (formerly Thaltitrexed; ICID1694; TDX; ZD-1694; D1694; ICI-D1694; trade name: Tomudex),a quinazoline folate analog, is an approved antimetabolite anticancer drug used in cancer chemotherapy for treating colorectal cancer and malignant mesothelioma. |
|
V81278 | RdRP-IN-6 | RdRP-IN-6 (compound 27) inhibits RNA dependent-RNA polymerase (RdRp) with an IC90 value of 14.1 μM. | |
|
V84237 | RecQ helicase-IN-1 | ||
|
V4300 | Remdesivir (GS-5734) | 1809249-37-3 | Remdesivir (GS-5734; Veklury) is an FDA approved drug for the treatment of 2019-nCoV (COVID-19 pandemic, CoronaVirus) infections requiring hospitalization. |
|
V2203 | Remdesivir O-desphosphate acetonide impurity | 1191237-80-5 | Remdesivir O-desphosphate acetonide impurity is a Remdesivirimpurity and an important intermediate to synthesize antiviral drug remdesivir. |
|
V4489 | RG3039 | 1005504-62-0 | RG3039 (also known as PF-06687859; PF 06687859), a member of a chemical series that was identified and optimized using an SMN2 promoter screen, is a novel, potent, orally bioavailable and brain-penetrant DcpS (decapping scavenger enzyme) inhibitor with an IC50 of 0.069 nM. |
|
V5680 | RG7800 | 1449598-06-4 | RG7800 (also known as RG-7800; RO6885247) is a potent and selective survival motor neuron 2 (SMN2) splicing modifier, which is currently being studies in human clinical trials for the treatment of Spinal Muscular Atrophy (SMA). |
|
V76558 | RG7800 tetrahydrochloride (RO6885247 tetrahydrochloride) | RG7800 HCl is an orally bioavailable SMN2 splicing modulator with EC1.5x values of 23 nM and 87 nM for SMN2 splicing and SMN protein, respectively. | |
|
V56159 | Ribonuclease H (RNase H) | 9050-76-4 | Ribonuclease H is an enzyme that degrades the RNA portion of DNA-RNA hybrids. |
|
V55111 | Ribonuclease T1 (Rnase T1) | 9026-12-4 | Ribonuclease T1 (RNase T1), commonly used in biochemical research. |
|
V1468 | Rifampin (Rifampicin) | 13292-46-1 | Rifampin (Rimactane; Arficin; Arzide; Rifampicin; Rifadin; Rimactane; Rimactan; Tubocin; Archidyn; Benemicin; Doloresum; Eremfat; Fenampicin; Sinerdol), an approved broad spectrum and semisynthetic antibiotic found in Streptomyces mediterranei, is mainly used to treat various bacterial infections such as TB-tuberculosis, leprosy,mycobacterium avium complex, and Legionnaires disease. |
|
V1469 | Rifaximin | 80621-81-4 | Rifaximin (BRN-3584528; L-105SV; Fatroximin; Normix; Rifacol; Rifaxidin; Rifaxin; Ritacol; Rifaximin; RCIFAX, Rifagut; Xifaxan; Zaxine) is an orally bioavailable and semi-synthetic RNA synthesis inhibitor used to treat travelers diarrhea caused by certain bacteria. |
|
V13787 | Rimantadine Hydrochloride | 1501-84-4 | Rimantadine HCl (Flumadine Hydrochloride) is a bioactive oral medication that inhibits the influenza virus and can be used to treat and prevent influenza A fever. |
|
V75896 | RNA polymerase II-IN-1 | 2891451-07-1 | RNA polymerase II-IN-1 (compound 19iv) is an amanitaxin that can inhibit RNA polymerase II (Pol II) with IC50 of 36.66 nM. |
|
V55157 | RNA splicing modulator 1 | 2726461-38-5 | RNA splicing modulator 1 (compound 233) is an RNA splicing modulator with AC50 value <100 nM. |
|
V55155 | RNA splicing modulator 2 | 2726461-41-0 | RNA splicing modulator 2 (compound 256) is an RNA splicing modulator. |
|
V55115 | RNA splicing modulator 3 | 2726461-43-2 | RNA splicing modulator 3 (compound 236) is an RNA splicing modulator with AC50 value <100 nM. |
|
V81317 | RNase III | RNase III is a double-stranded RNA (dsRNA)-specific endonuclease produced by Escherichia coli expressing the RNase III gene. | |
|
V81318 | RNaseL-IN-1 | RNase L-IN-1 (compound 17a) is an inhibitor (blocker/antagonist) of RNase L or ribonuclease L. |
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