DNA(RNA) Synthesis

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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DNA(RNA) Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.

In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.

M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.

DNA(RNA) Synthesis related products

Cat No.	Product Name	CAS No.	Product Description
V101982	PHYLPA-8	169736-88-3	PHYLPA-8 is an inhibitor of DNA polymerase α and exhibits weak DNA polymerase α inhibitory activity due to its fatty acid moiety and cyclic phosphate stereochemical structure.
V81142	PINT-87aa		PINT-87aa is an 87-amino acid (AA) peptide encoded by the circular form of the long intergenic nonprotein-coding RNA p53-induced transcript (LINC-PINT).
V81143	PINT-87aa TFA		PINT-87aa TFA is an 87-amino acid (AA) peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT).
V75900	Pol I-IN-1	2765318-69-0	Pol I-IN-1 is a potent inhibitor of RNA polymerase I (Pol I) with IC50 of 0.21 µM for the large Pol I catalytic subunit RPA194.
V53287	POL1-IN-1	1822358-25-7	POL1-IN-1 is a RNA polymerase 1 POL1 (also known as Pol I) inhibitor with an IC50 value of less than 0.5 uM.
V101216	PolQi1	2607139-80-8	PolQi1 is a Polϴ (polymerase θ) inhibitor.
V100323	POLRMT-IN-1		POLRMT-IN-1 (compound S7) is a POLRMT inhibitor.
V55159	Poly(A) polymerase	9026-30-6	Poly(A) polymerase catalyzes the addition of a polyadenosine tail, or ATP, to the 3' end of RNA in the form of AMP.
V75901	Polynucleotide kinase	37211-65-7	Polynucleotide Kinase is a DNA repair enzyme.
V92056	Polθ-IN-3	2922287-81-6	Polθ-IN-3 (Compound 113) is an orally active polymerase theta (Polθ) inhibitor.
V99833	Polθ-IN-4	3043810-73-4	Polθ-IN-4 (Example 1) is a DNA polymerase Theta (Polθ) inhibitor that inhibits Polθ activity by targeting its ATP-dependent helicase domain.
V93140	Polθ-IN-5	3058636-12-4	Polθ-IN-5 (Compound 139) is a DNA polymerase θ (Polθ) inhibitor.
V93133	Polθ-IN-6	3058496-94-6	Polθ-IN-6 (Compound 89) is a DNA polymerase θ (Polθ) inhibitor.
V103423	Polθ-IN-7	2923356-52-7	Polθ-IN-7 (Example 12) is a DNA polymerase θ (Polθ) inhibitor with a Ki of 1.27 nM.
V81203	Procaine-d4 hydrochloride (procaine d4 hydrochloride)		Procaine-d4 ( HCl) is the deuterated form of Procaine HCl.
V55119	Prunasin	99-18-3	Prunasin is an inhibitor (blocker/antagonist) of DNA Polymerase β.
V103166	Purine riboside-5'-O-triphosphate sodium	35892-95-6	Purine nucleoside-5'-O-triphosphate sodium is an active metabolite of Nebularine (HY -103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities with IC50 values of 35 µM and 28 µM, respectively.
V1433	Pyridostatin Trifluoroacetate (RR82)	1472611-44-1	Pyridostatin Trifluoroacetate(RR82; RR 82; RR-82; PDS; Pyridostatin TFA), the Trifluoroacetate(TFA) salt of Pyridostatin, is a G-quadruplexe stabilizer with potential antineoplastic activity.
V80291	qsl-304		qsl-304 is a DNA gyrase B inhibitor.
V34728	Quinizarin (1,4-Dihydroxyanthraquinone; 1,4-Dihydroxyanthraquinone)	81-64-1	Quinizarin (1,4-Dihydroxyanthraquinone) is a part of anti-cancer active molecules such as Doxorubicin, Daunorubicin, Adriamycin, etc.