RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84130 | DHX9-IN-15 | 2973398-27-3 | |
|
V84136 | DHX9-IN-16 | 2973397-48-5 | |
|
V84133 | DHX9-IN-17 | 2973397-26-9 | |
|
V86205 | DHX9-IN-6 | 2973401-56-6 | |
|
V84138 | DHX9-IN-7 | 2973400-87-0 | |
|
V83897 | DHX9-IN-8 | 2973746-64-2 | |
|
V84155 | DHX9-IN-9 | 2973400-46-1 | |
|
V55113 | Di-tert-butyl diisopropylphosphoramidite | 137348-86-8 | Di-tert-butyl diisopropylphosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
|
V5043 | Didox (NSC-324360) | 69839-83-4 | Didox (also known as NSC-324360) is a novel, potent and synthetic ribonucleotide reductase (RR) inhibitor. |
|
V79130 | Diguanosine 5′-triphosphate lithium (Gp3G lithium) | Diguanosine 5′-triphosphate (Gp3G) lithium is a dinucleoside triphosphate. | |
|
V55188 | DMT-2'-F-6-chloro-dA phosphoramidite | 2803878-95-5 | DMT-2'-F-6-chloro-dA phosphoramidite is a phosphoramidite monomer that can be used for solid-phase synthesis of oligonucleotides. |
|
V55204 | DMT-2'-F-Cytidine Phosphoramidite | 200404-36-0 | DMT-2'-F-Cytidine Phosphoramidite is a phosphoramidite monomer that can be used for solid-phase synthesis of oligonucleotides. |
|
V55200 | DMT-2'-F-dA Phosphoramidite | 252770-65-3 | DMT-2'-F-dA Phosphoramidite is a phosphoramidite monomer that can be used for solid-phase synthesis of oligonucleotides. |
|
V55205 | DMT-2'-F-dA(bz) phosphoramidite | 2659239-37-7 | DMT-2'-F-dA(bz) phosphoramidite is a phosphoramidite monomer that may be utilized in the solid-phase synthesis of oligonucleotides. |
|
V55182 | DMT-2'-O-Methyladenosine phosphoramidite | 138906-75-9 | DMT-2'-O-Methyladenosine phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
|
V55203 | DMT-2'-O-Methylguanosine phosphoramidite | 1159683-24-5 | DMT-2'-O-Methylguanosine phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
|
V55171 | DMT-2'-O-TBDMS-G(dmf)-CE-phosphoramidite | 149559-87-5 | (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((E)- (dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite monomer that may be utilized in oligonuclear Solid-phase synthesis of glycosides. |
|
V55197 | DMT-2'-OMe-dA(bz) phosphoramidite | 2659239-32-2 | DMT-2'-OMe-dA(bz) phosphoramidite is a phosphoramidite monomer that may be utilized in the solid-phase synthesis of oligonucleotides. |
|
V52940 | DMT-2'fluoro-da(bz) amidite | 136834-22-5 | Dmt-2'fluoro-da(bz) amidite, a homogeneously modified 2'-deoxy-2'-fluorophosphorothioate oligonucleotide, is a potent nuclease-resistant antisense compound that targets RNA. |
|
V55189 | DMT-2'O-Methyl-rC(tac) phosphoramidite | 179486-26-1 | DMT-2'O-Methyl-rC(tac) Phosphoramidite is a phosphoramidite monomer that may be utilized in the solid-phase synthesis of oligonucleotides. |
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