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Integrin

Integrin

Integrins, a family of heterodimeric adhesion receptors for various extracellular matrices, have repeatedly been linked to being important initiators and promoters of ovarian cancer growth and progression. Aggressive ovarian tumors exhibit significantly elevated levels of several RGD-based integrin family members, including integrins 5-1 and v3 or v5. These adhesion receptors appear to encourage cell adhesion, survival, motility, and invasion during the development of an ovarian tumor or the spread of its metastatic disease. Notably, the activation of FAK and its downstream signaling, including the PI3K/Akt- and Ras/MAPK-dependent pathways, is crucial for the functions of these integrins.

Transmembrane proteins called integrins serve as important receptors for cell-extracellular matrix (ECM) and cell-cell adhesion.These molecules can be modified, and the v integrin family in particular, has shown to have significant effects on fibrosis in a variety of organs and disease states. According to numerous studies, the latent transforming growth factor (TGF)- is activated by the integrins v3, v5, v6, and v8 in pre-clinical fibrosis models, modulating the fibrotic process.

One of the 18 different types of subunits that are known to exist and one of the eight different types of subunits that are known to exist are typically non-covalently paired to form each integrin. There are currently 24 different heterodimers in total. The fact that the v subunit can form heterodimers with the 1, 3, 5, 6 or 8 subunits and that the 1 subunit can associate with a wide variety of subunits from 1 to 11 shows that not all theoretically possible and subunit pairs form. It's intriguing to note that a variety of v integrins appear to share a common function in TGF- activation.

Integrin related products

Structure Cat No. Product Name CAS No. Product Description
GRGDSP TFA V76961 GRGDSP TFA GRGDSP (TFA) is an integrin inhibitor.
GSK3335103 V96713 GSK3335103 1893340-21-0 GSK3335103 is an orally active non-peptide αvβ6 integrin inhibitor (pIC50=8) that can be used in the study of pulmonary fibrosis.
HB-3-20 V106186 HB-3-20 HB-3-20 induces degradation of cell surface integrin αVβ5.
HSDVHK-NH2 V27085 HSDVHK-NH2 848644-86-0 HSDVHK-NH2 is an inhibitor (blocker/antagonist) of the integrin αvβ3-vitreous binding protein interaction with IC50 of 1.74 pg/mL (2.414 pM).
HSDVHK-NH2 TFA V80311 HSDVHK-NH2 TFA HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitreous binding protein interaction with IC50 of 1.74 pg/mL (2.414 pM).
Integrin Binding Peptide V53238 Integrin Binding Peptide 278792-07-7 Integrin Binding Peptide is developed from fibronectin.
Integrin modulator 1 V51946 Integrin modulator 1 2023788-32-9 Integrin modulator 1 is a potent and specific α4β1 integrin agonist/activator with IC50 of 9.8 nM.
Integrin-IN-2 V56043 Integrin-IN-2 2378617-67-3 Integrin-IN-2 is an orally bioavailable pan-αv integrin (αv integrin) inhibitor.
iRGD peptide TFA salt V33012 iRGD peptide TFA salt 1392278-76-0 iRGD peptide(sequence: CRGDKGPDC) is a 9-amino acid cyclic peptide, and a molecular mimicry agent that was originally identified in an in vivo screening of phage display libraries in tumor-bearing mice.
KGDS V56050 KGDS 93674-95-4 KGDS is a synthetic peptide that targets integrin GPIIb-IIIa on the cell membrane of human activated platelets.
LDV V51875 LDV 1155866-55-9 LDV is a tripeptide and non-fluorescent analog of LDV-FITC.
LDV-FITC V56059 LDV-FITC 1207610-07-8 LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide.
LDV-FITC TFA V88817 LDV-FITC TFA LDV-FITC TFA, a fluorescent peptide, is a FITC-conjugated LDV peptide.
Leukadherin-1 V3005 Leukadherin-1 344897-95-6 Leukadherin-1,formerly known as LA1, isa novel and specific agonist of Complement receptor 3 (CR3)and the leukocyte surface integrin CD11b/CD18 that enhances leukocyte adhesion to ligands and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites.
Lys-Gln-Ala-Gly-Asp-Val V51833 Lys-Gln-Ala-Gly-Asp-Val 80755-87-9 Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acid (AA)s in the fibrinogen γ-chain sequence.
MK-0429 V3953 MK-0429 227963-15-7 MK-0429 is a compound that was originally developed as a selective and potent αvβ3 inhibitor for the treatment of osteoporosis, on renal function and fibrosis.
MORF-627 V103355 MORF-627 2412688-16-3 MORF-627 is an oral, selective integrin αvβ6 inhibitor with IC50 of 9.2 nM as measured by human serum ligand binding assay.
mP6 (Myr-FEEERA-OH) V75802 mP6 (Myr-FEEERA-OH) 2700321-79-3 mP6 (Myr-FEEERA-OH) is a myristoylated peptide.
N-Acetyl-S-geranylgeranyl-L-cysteine V103231 N-Acetyl-S-geranylgeranyl-L-cysteine 139332-94-8 N-Acetyl-S-geranylgeranyl-L-cysteine is a methyltransferase inhibitor.
Obtustatin V80983 Obtustatin 404882-00-4 Obtustatin is a 41-residue non-RGD disintegrin.
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