5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V5162 | Pindolol (LB-46) | 13523-86-9 | Pindolol (known also as LB-46), a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, is an aryloxypropanolamine derivative with antihypertensive property. |
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V71228 | Pindolol-d7 (Pindolol d7) | 1185031-19-9 | Pindolol-d7 is the deuterated form of Pindolol. |
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V1036 | Prucalopride (R-108512, R-93877) | 179474-81-8 | Prucalopride (Motegrity; R-108512; R 108512;Resolor; Resotran; R108512; Prudac),a novel enterokinetic compound andthe first representative drug of the benzofuran class oflaxatives, is a selective and high affinity 5-HT (serotonin) receptor agonist withKis of 2.5 nM and 8 nM for 5-HT4A and 5-HT4B receptor, respectively. |
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V0973 | Prucalopride Succinate (R-108512, R-93877) | 179474-85-2 | Prucalopride (R 108512; R108512; R 108512; trade names: Resolor; Resotran; Motegrity),a novel enterokinetic and benzofuran-based compound, is a novel, selective, high affinity 5-HT (serotonin) receptor agonist for 5-HT4A and 5-HT4B receptor with anti-idiopathic constipation activity. |
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V2617 | PRX-08066 | 866206-54-4 | PRX-08066 is a potent andselective 5-HT2B receptor antagonist with IC50 of 3.4 nM, it prevents the severity of pulmonary arterial hypertension in the MCT rat model. |
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V0969 | PRX-08066 Maleic acid | 866206-55-5 | PRX-08066 maleic acid (MT500; MT-500; PRX 08066; PRX08066), the maleic acid salt of PRX08066, is a novel, potent and selective 5-HT2B receptor antagonist with important biological activity. |
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V2391 | Puerarin (Kakonein) | 3681-99-0 | Puerarin (Kakonein), a naturally occuring isoflavone isolated from the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. |
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V9837 | Quetiapine | 111974-69-7 | Quetiapine Fumarate (also known as ICI-204636; trade name Seroquel) is a dibenzothiazepine-based atypical antipsychotic agent acting as a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. |
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V1282 | Quetiapine Fumarate (ICI 204636)) | 111974-72-2 | Quetiapine Fumarate (Seroquel XR; IC-204,636; ICI204,636; ICI-204636), the fumarate salt of Quetiapine, is an atypical antipsychotic drug used for the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression. |
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V71211 | Quetiapine-d8 fumarate (quetiapine d8 fumarate) | 1185247-12-4 | Quetiapine-d8 (fumarate) is the deuterated form of Quetiapine hemifumarate. |
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V78945 | Quetiapine-d8 hemifumarate (quetiapine d8 (hemifumarate)) | Quetiapine-d8 (hemifumarate) is the deuterated form of Quetiapine hemifumarate. | |
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V71216 | R-96544 free base | 167144-79-8 | R-96544 (free base) is a specific, competitive 5-HT2 receptor antagonist. |
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V83206 | R-96544 HCl | 167144-80-1 | R-96544 HCl is an orally bioactive 5-HT2A receptor antagonist, and can inhibit platelet aggregation in vitro |
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V7278 | Ramosetron hydrochloride | 132907-72-3 | Ramosetron (YM060) HCl is a 5-HT3 receptor blocker (antagonist) used to study nausea and vomiting. |
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V71165 | Renzapride (BRL 24924) | 112727-80-7 | Renzapride (BRL 24924), a substituted benzamide, is a 5-HT4 receptor agonist and a 5HT2b and 5HT3 receptor antagonist. |
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V71131 | Repinotan (BAY x 3702 free base) | 144980-29-0 | Repinotan (BAY x 3702 free base) is a specific, BBB (blood-brain barrier) permeable (penetrable), and orally bioactive 5-HT1A receptor agonist/activator with a Ki of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex) and 0.59 nM (rat hippocampus). |
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V85498 | Revospirone (BAY Vq 7813) | 95847-87-3 | |
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V0982 | Risperidone (R-64766; Risperdal) | 106266-06-2 | Risperidone (R-64766; R64766 and Risperdal), an marketed atypical antipsychotic, is a potent multi-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, it has been approved for use in the treatment of schizophrenia and bipolar disorder. |
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V29718 | Risperidone hydrochloride | 666179-74-4 | Risperidone HCl is the hydrochloride salt of Risperidone (R64766; R-64766; Risperdal), which is an approved atypical antipsychotic for the treatment of schizophrenia and bipolar disorder. |
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V13809 | Risperidone Mesylate | 666179-96-0 | Risperidone mesylate is the mesylate saltof Risperidone (R64766; Risperdal), which is an approved atypical antipsychotic and a blocker of dopamine D2 receptors as well as serotonin 5-HT2 receptors. |
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