5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V0979 | Rizatriptan Benzoate (MK-462 Benzoate) | 145202-66-0 | Rizatriptan Benzoate (Maxalt; formerly MK 0462; MK 462)is a potent and selective agonist at serotonin 5-HT1B and 5-HT1D receptors with anti-migraine activity. |
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V4698 | Roluperidone | 359625-79-9 | Roluperidone (formerly also known as CYR-101, MIN-101, CYR101, and MT-210) is a novel and potent cyclic amide derivative with-schizophrenia effects. |
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V71167 | RS 23597-190 (EP-A-501322) | 149719-06-2 | RS 23597-190 (EP-A-501322) is a high-affinity and selective 5-HT4 receptor antagonist. |
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V0968 | RS-127445 | 199864-87-4 | RS-127445 (RS 127445; RS127445) is a novel, potent, selective, and orally bioavailable 5-HT2B receptor antagonist with important biological activity. |
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V71137 | RU 24969 hemisuccinate | 66611-27-6 | RU 24969 hemisuccinate is a preferential 5-HT1B agonist/activator with a Ki of 0.38 nM. |
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V86151 | SB 206553 | 158942-04-2 | |
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V4607 | SB 242084 HCl | 1049747-87-6 | SB-242084 HCl, the hydrochloride salt ofSB 242084, is a novel, potent and selective 5-HT2C receptor antagonist with pKi of 9.0 and with 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. |
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V71123 | SB 243213 | 200940-22-3 | SB 243213 is an orally bioactive, selective, high-affinity 5-HT2C receptor antagonist (inhibitor) with pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor. |
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V0984 | SB 271046 (SB-271046A) | 209481-20-9 | SB271046 (SB 271046; SB-271046; SB-271046A; SB271046A) is a novel, potent, selective and orally bioactive 5-HT6 receptor antagonist with important biological activity. |
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V0980 | SB 271046 HCl (SB-271046A) | 209481-24-3 | SB271046 HCl (SB 271046; SB-271046), the hydrochloride salt of SB 271046, is a novel, potent, selective and orally bioactive 5-HT6 receptor antagonist with potential anticonvulsant activity. |
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V71150 | SB-200646A | 143797-62-0 | SB-200646A is the first antagonist selective for 5-HT2B/2C over 5-HT2A, with pKis of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A respectively. |
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V4617 | SB-399885 HCl | 402713-81-9 | SB 399885 hydrochloride is a novel, potent, brain penetrant, and orally bioactive 5-HT6 receptor antagonist. |
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V2619 | SB269970 (SB-269970A) | 201038-74-6 | SB269970 (SB-269970A)is a novel and potent 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors. |
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V1019 | SB269970 HCl (SB-269970A) | 261901-57-9 | SB269970 HCl (SB 269970; GR125743; GR-125743; SB-269970), the hydrochloride salt form of SB-269970, is a novel and potent 5-HT7 receptor antagonist withantianxiety-like effects. |
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V71169 | SB399885 | 402713-80-8 | SB399885 is a specific, BBB (blood-brain barrier) permeable (penetrable) and orally bioactive 5-HT6 receptor antagonist (inhibitor) with pKis of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. |
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V2291 | SEP-363856 HCl (Ulotaront) | 1310422-41-3 | SEP-363856 HCL (also known as Ulotaront; SEP363856; SEP-856 HCL), is a novel and potent orally bioactivetrace amine-associated receptor 1 (TAAR1) agonist with serotonin 1A (5-HT1A) agonist activity. |
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V0993 | Serotonin HCl | 153-98-0 | Serotonin HCl (5-HT HCl; 5-Hydroxytryptamine), the hydrochloride salt of Serotonin, is an endogenous monoamine neurotransmitter found in the brain and also an endogenous agonist of 5-HT receptor. |
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V6700 | Sertindole | 106516-24-9 | Sertindole (Sertindolum; Lu 23-174) is a potent antipsychotic medication and a neuroleptic drug. |
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V1029 | Sertraline HCl | 79559-97-0 | Sertraline HCl (formerly CP 51,974-1; CP 51974-1; CP-51,974; trade names: Sealdin; Adjuvin; Atruline; Gladem; Tatig; Tresleen; Zoloft), the hydrochloride salt of Sertraline, is a potent and marketed antidepressant drug acting as a 5-HT serotonin receptor antagonist with Ki of 13 nM. |
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V71197 | Setiptiline-d3 (Setiptiline-d3) | 1795024-97-3 | Setiptiline-d3 is the deuterated form of Setiptiline. |
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