5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0989 | Zolmitriptan | 139264-17-8 | Zolmitriptan (311C90; 311 C90; trade names AscoTop, Zomig, Zomigon, Zomigoro), an approved drug for the treatment of acute migraines, is a potent and highly selective 5-HT(1B/1D) receptor agonist of the triptan class. |
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V25760 | Zotepine | 26615-21-4 | Zotepine is a potent and 2nd generation antipsychotic with antidepressive and anxiolytic effects and can be used for the treatment for schizophrenia. |
|
V71179 | α-Methylerotonin | 304-52-9 | α-Methylserotonin is a potent and specific agonist of 5-HT2 receptors. |
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V24511 | Lumateperone HCl | Lumateperone HCl(ITI-722, ITI-007; Caplyta), the hydrochloric acid salt of Lumateperone,is a dual 5HT2A receptor antagonist and dopamine receptor phosphoprotein modulator (DPPM), approved as an atypical antipsychotic in 2019 for the treatment of schizophrenia. |
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