5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V19012 | Cyproheptadine HCl hydrate | 41354-29-4 | Cyproheptadine HCl hydrate is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. |
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V0977 | Dapoxetine HCl (LY-210448 HCl) | 129938-20-1 | Dapoxetine HCl (formerly known as LY210448; LY-210448; trade name Priligy), an antidepressant, is a novel, potent, short-acting and selective serotonin reuptake inhibitor (SSRI) that has alto been used for the treatment of premature ejaculation. |
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V71162 | Dehydro Palonosetron (RS 42358-197) | 135729-56-5 | Dehydro Palonosetron (RS 42358-197) is a specific, orally bioactive 5-HT3 receptor antagonist. |
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V71141 | Dehydroaripiprazole hydrochloride (OPC-14857 hydrochloride; DM-14857 hydrochloride) | 1008531-60-9 | Dehydroaripiprazole (OPC-14857) HCl is the bioactive metabolite of Aripiprazole. |
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V1034 | Desvenlafaxine (WY 45233; O-Desmethylvenlafaxine) | 93413-62-8 | Desvenlafaxine (WY-45233; WY45233; brand names Pristiq, Desfax), the active metabolite of the antidepressant venlafaxine, is a potent inhibitor/antagonist of the reuptake of serotonin (5-HT) transporter and norepinephrine (NE) transporter with Ki of 40.2 nM and 558.4 nM respectively. |
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V1033 | Desvenlafaxine Succinate (WY 45233; O-Desmethylvenlafaxine) | 448904-47-0 | Desvenlafaxine Succinate (formerly WY45233; WY 45233; O-desmethylvenlafaxine; trade name Pristiq, Desfax), the succinate salt of Desvenlafaxine which is an approved antidepressant drug, is a novel and potent serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
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V71127 | Didesmethyl cariprazine | 839712-25-3 | Didesmethyl cariprazine is a metabolite of cariprazine and serves as the major circulating active moiety. |
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V18113 | Dihydroergotamine Mesylate (DHE; Migranal) | 6190-39-2 | Dihydroergotamine Mesylate (DHE; Migranal) is a naturally occuring ergot alkaloid widely used to treat migraines. |
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V71144 | DOI hydrochloride | 42203-78-1 | DOI HCl is a serotonin 5-HT2A/2C receptor agonist/activator with Kis of 0.7 nM, 2.4 nM and 20 nM for h5-HT2A, h5-HT2C and h5-HT2B receptors respectively. |
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V15974 | Dolasetron (MDL-73147) | 115956-12-2 | Dolasetron (MDL-73147) is a potent serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
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V71118 | Donitriptan hydrochloride (F-11356) | 170911-68-9 | Donitriptan HCl (F-11356) is a potent, high-affinity 5-HT1B/1D receptor agonist (activator) with pKi of 9.4 and 9.3, respectively. |
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V18170 | Duloxetine ((S)-Duloxetine; LY248686) | 116539-59-4 | Duloxetine ((S)-Duloxetine; LY248686; LY-248686) is a serotonin-norepinephrine reuptake inhibitor(SNRI, Ki = 4.6 nM) used for treatment of major depressive disorder and generalized anxiety disorder (GAD),fibromyalgia and neuropathic pain. |
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V1016 | Duloxetine HCl (LY-248686 HCl) | 136434-34-9 | Duloxetine HCl (formerly LY-248686 HCl; LY248686; trade names Cymbalta; Yentreve), the hydrochloride salt of Duloxetine which is an approved antidepressant medication, is a potent serotonin-norepinephrine reuptake inhibitor (SNRI) with potential anti-depressive activity. |
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V71160 | DV-7028 hydrochloride | 133364-62-2 | DV-7028 is a selective serotonin 2 (5-HT2) receptor blocker (antagonist). |
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V0995 | Eletriptan HBr | 177834-92-3 | Eletriptan (formerly UK 116044; UK-116,044; UK-116,044-04; trade name Relpax), a triptan class of medication used for treatment of migraine headaches, is a potent and selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively. |
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V71220 | Eletriptan-d3 (UK-116044-d3) | 1287040-94-1 | Eletriptan-d3 is the deuterium labelled form of Eletriptan HBr. |
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V71192 | Eletriptan-d5 | 1126745-65-0 | Eletriptan-d5 is the deuterated form of Eletriptan. |
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V79286 | Eletriptan-d5 hydrochloride | Eletriptan-d5 ( HCl) is the deuterated form of Eletriptan HCl. | |
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V71206 | Eltoprazine dihydrochloride (DU 28853 dihydrochloride) | 143485-51-2 | Eltoprazine (DU 28853) diHCl is a 5-HT1A/5-HT1B receptor agonist (activator) and 5-HT2C receptor blocker (antagonist). |
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V4999 | Eltoprazine HCl | 98206-09-8 | Eltoprazine HCl (formerly DU-28853; DU28853 hydrochloride) is a novel and potent serenic or antiaggressive agent which also acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor. |
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