5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V107602 | AL-LAD | 65527-61-9 | AL-LAD (6-allyl-6-n-LSD) is an activator of 5-HT2A receptor with Ki value of 3.4-8.1 nM. |
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V101827 | Alaproclate | 60719-82-6 | Alaponic acid is a serotonin (5-HT) reuptake inhibitor. |
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V104682 | ALEPH hydrochloride | 61638-08-2 | ALEPH (hydrochloride) is a partial agonist for h5-HT2A and h5-HT2B with EC50 of 10.3 nM and 19.2 nM, respectively. |
|
V86141 | Almotriptan hydrochloride | 154323-46-3 | |
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V94302 | Alprenolol benzoate | 67824-72-0 | Alprenolol benzoate is an oral non-selective β-adrenergic receptor antagonist and a 5-HT1A and 5-HT1B receptor antagonist. |
|
V71119 | Alverine citrate (NSC 35459) | 5560-59-8 | Alverine citrate is an antagonist of the 5-HT1A receptor with IC50 of 101 nM. |
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V79060 | AM9405 | 3032946-55-4 | AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. |
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V104197 | Ammuxetine | 1202707-24-1 | Ammuxetine (071031B) is a chiral compound that is a 5-HT and norepinephrine reuptake inhibitor (SSRI) with antidepressant effects and can be used in research related to depression. |
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V85420 | Ampreloxetine TFA (TD-9855 TFA) | 1227056-85-0 | |
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V79367 | Antipsychotic agent-2 | Antipsychotic agent-2 (Compound 11) is a potent antipsychotic agent. | |
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V71184 | Aripiprazole (1,1,2,2,3,3,4,4-d8) (Aripiprazole (1,1,2,2,3,3,4,4-d8)) | 1089115-04-7 | Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterated form of Aripiprazole. |
|
V93092 | ASP-2205 | 1334440-09-3 | ASP-2205 is a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM). |
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V94270 | AVN-322 free base | 1194574-33-8 | AVN-322 free base is an orally active, highly selective 5-HT6R antagonist used in the research of central nervous system disorders. |
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V2807 | AVN-492 | 1220646-23-0 | AVN-492 is a highly specific, selective and orally bioavailable antagonist of the 5-HT6R with Kiof 91 pM. |
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V71126 | Befiradol hydrochloride (NLX-112 hydrochloride; F 13640 hydrochloride) | 2436760-81-3 | Befiradol HCl (NLX-112 HCl) is a selective serotonin 1A (5-HT)1A receptor agonist (activator). |
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V71166 | BIMU 8 | 134296-40-5 | BIMU 8 is a potent and specific 5-HT4 agonist/activator with EC50s of 18 nM, 77 nM and 540 nM for the wild-type 5HT4 receptor, T3.36A and W6.48A mutant 5-HT4 receptors. |
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V93816 | Binospirone | 102908-59-8 | Binospirone is a 5-HT1A receptor agonist. |
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V71158 | Blonanserin-d5 (AD-5423-d5) | 1346599-86-7 | Blonanserin-d5 is the deuterium labelled form of Blonanserin. |
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V0987 | BMY 7378 dihydrochloride | 21102-95-4 | BMY 7378 (BMY-7378; BMY7378) dihydrochloride is a multi-target compound that inhibits α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively. |
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V71354 | Bopindolol fumarate (bopindolol fumarate; (±)-Bopindolol fumarate) | 79125-22-7 | Bopindolol ((±)-Bopindolol) fumarate is an orally bioactive beta-adrenoceptor (ARs) antagonist (inhibitor) with partial agonist activity. |
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