5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71133 | EMD 56551 | 133109-86-1 | EMD 56551 is a potent and specific 5-HT1A receptor agonist (activator). |
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V20658 | Eptapirone(F11440) | 179756-58-2 | Eptapirone (formerly known as F11440; L0068) is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. |
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V1030 | Escitalopram Oxalate (Citalopram oxalate) | 219861-08-2 | Escitalopram Oxalate (Cipralex; Lexapro; Lu10171; Lu-10171; Citalopram; Cytalopram), the oxalate salt of Escitalopram which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) with a Ki of 0.89 nM. |
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V20852 | Eucalyptol | 470-82-6 | Eucalyptol (1,8-epoxy-p-Menthane; Cineole; 1,8-Cineole; NSC-617) is an organic compound and a colorless liquid, acting an inhibitor of 5-HT3 receptor ,potassium channel, TNF-α and IL-1β. |
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V51043 | Eucalyptol-d6 | 1263091-00-4 | Eucalyptol-d6 is the deuterium labelled form of Eucalyptol. |
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V3527 | F13714 fumarate | 208109-39-1 | F13714 fumarate is a selective 5-HT1A receptor biased agonist with antidepressant-like properties after a single dose in a mouse model of chronic mild stress. |
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V20913 | Fananserin | 127625-29-0 | Fananserin (RP-62203; RP62203) is a novel and potent antipsychotic agent acting as a5-hydroxytryptamine2 (5-HT2) receptor antagonist (Ki = 0.37 nM for the rat 5-HT2A receptor). |
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V1971 | Flopropione | 2295-58-1 | Flopropione is a spasmolytic or antispasmodic agent, acting as a 5-HT1A receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor. |
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V85188 | Flufylline (Flufylline; Sgd 195/78) | 82190-91-8 | |
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V0965 | Fluoxetine HCl (LY-110140) | 56296-78-7 | Fluoxetine HCl (LY-110140; Lilly-110140; Prozac, Sarafem, Animex-On, Pulvules, Eufor, Portal), the HCl salt of fluoxetine, is a potent and selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane with anti-depressant activity. |
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V1017 | Fluvoxamine maleate (DU23000 maleate) | 61718-82-9 | Fluvoxamine Maleate (formerly DU 23000; MK264; MK 264; DU-23000; Faverin, Fevarin, Floxyfral, Luvox), the maleate salt of Fluvoxamine which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) used in the treatment of a variety of diseases including obsessive-compulsive disorder, major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD). |
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V85098 | FPIP | ||
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V71208 | FPPQ | 1648745-46-3 | FPPQ is a dual-acting (bifunctional) 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist (inhibitor) with antipsychotic and pro-cognitive properties. |
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V4126 | Frovatriptan Succinate | 158930-09-7 | Frovatriptan Succinate (KB-295988; LS-173538; FT-0668872; D04264; Miguard; SB 209509), the succinate salt of frovatriptan, is a synthetic triptan that acts as an agonist of the serotonin (5-HT) receptor. |
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V80211 | Frovatriptan-d3 hydrochloride ((R)-Frovatriptan-d3 hydrochloride; SB 209509-d3 hydrochloride; VML 251-d3 hydrochloride) | Frovatriptan-d3 ( HCl) is the deuterated form of Frovatriptan. | |
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V29956 | Geissoschizine methyl ether | 60314-89-8 | Geissoschizine methyl ether, a naturally occuring indole alkaloid extrated from Uncaria hook, is a major active component of Yokukansan with psychotropic effects. |
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V21749 | GR 127935 HCl | 148642-42-6 | GR127935 HCl (GR-127935; GR 127935) is a novel, highly potent and selective 5-HT1B/1D receptor antagonist with pKis of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors. |
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V0976 | Granisetron HCl (BRL 43694A) | 107007-99-8 | Granisetron HCl (BRL-43694; BRL43694; BRL-43694A; trade name: Kytril), an approved antiemetic drug, is a potent serotonin 5-HT3 receptor antagonist with antiemetic activity. |
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V2903 | GSK163090 | 844903-58-8 | GSK163090 is novel, potent, selective, and orally bioavailable antagonist of the 5-HT1A/B/D receptor that has the potential to be used as a fast-onset antidepressant/anxiolytic. |
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V1037 | Iloperidone (HP-873) | 133454-47-4 | Iloperidone (Fanapt, HP-873; HP 873; Zomaril), an atypical antipsychotic agent, is a potent antagonist of dopamine (D2)/serotonin (5-HT2) receptor which has been approved for the treatment of schizophrenia symptoms. |
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