5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4839 | LY-344864 HCl | 1217756-94-9 | LY-344864 HCl, the hydrochloride salt of LY344864, is a novel, potent and selective receptor agonist of 5-HT1F with Ki of 6 nM. |
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V71152 | LY266097 hydrochloride | 172895-39-5 | LY266097 HCl is a selective 5-HT2B receptor antagonist (inhibitor) with pKi of 7.7, 9.8 and 7.6 for 5-HT2A, 5-HT2B and 5-HT2C respectively. |
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V0981 | LY310762 | 192927-92-7 | LY310762 (LY-310762; LY 310762) is a potent 5-HT1D serotonin receptor antagonist with important biological activity. |
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V32168 | LY334370 | 182563-08-2 | LY334370 is a selective 5-HT1F receptor agonist (activator) with Ki of 1.6 nM. |
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V71180 | m-CPBG hydrochloride (1-(3-Chlorophenyl)biguanide hydrochloride) | 2113-05-5 | m-CPBG (1-(3-Chlorophenyl)biguanide) HCl is a selective 5-HT3 agonist. |
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V71214 | Melitracen-d6 hydrochloride (melitacen d6 hydrochloride) | 1189648-08-5 | Melitracen-d6 ( HCl) is the deuterated form of Melitracen HCl. |
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V51293 | Metergoline | 17692-51-2 | Metergoline is a serotonin (5-HT) receptor and dopamine receptor antagonist (inhibitor) with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C respectively. |
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V25371 | Methotrimeprazine | 60-99-1 | Methotrimeprazine(Levomepromazine) is a potent phenothiazine-based neuroleptic drug. |
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V71154 | Methylergometrine (Methylergonovine; Ryegonovin free base; Spametrin F free base) | 113-42-8 | Methylergometrine (Methylergonovine) is an orally bioactive 5-HT2B ligand agonist. |
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V25462 | Metoclopramide hydrochloride hydrate | 54143-57-6 | Metoclopramide HCl hydrate is a potent and selective dopamine D2 receptor antagonist. |
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V71191 | Metoclopramide-d3 | 1216522-89-2 | Metoclopramide-d3 is the deuterated form of Metoclopramide. |
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V1018 | Mirtazapine (Org3770; 6-Azamianserin) | 85650-52-8 | Mirtazapine (formerly Org3770, Org 3770; trade names Remeron, Avanza, Axit, Mirtazon, Zispin),an approved atypical antidepressant drug, is an adrenergic and serotonin receptor antagonist used for treating depression. |
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V4286 | MK 0893 | 870823-19-1 | MK-0893 (CRA1; MK0893) is a novel, potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM. |
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V0994 | Mosapride Citrate (TAK-370; AS-4370) | 112885-42-4 | Mosapride Citrate (formerly AS-4370; TAK-370 citrate; AS-4370 citrate; TAK 370 citrate) is a novel, potent and selective gastroprokinetic agent that has been used in patients with upper gastrointestinal disorders. |
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V80839 | MRS7925 | MRS7925 (Compound 43) is a 5-HT2BR antagonist (Ki= 17 nM). | |
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V71122 | NAN-190 hydrobromide | 115338-32-4 | NAN-190 HBr is a serotonin receptor 5-HT receptor blocker (antagonist). |
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V71188 | Nantenine | 2565-01-7 | Nantenine is a serotonin receptor antagonist. |
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V1028 | Naratriptan HCl (GR-85548A HCl) | 143388-64-1 | Naratriptan HCl (GR-85548A; GR85548A; Amerge; Naramig), the hydrochloride salt of naratriptan, is a triptan class of selective 5-HT₁ receptor subtype agonist used for the treatment of migraine headaches. |
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V71217 | Naratriptan-d3 (GR-85548A-d3-1) | 1190043-69-6 | Naratriptan-d3 is the deuterium labelled form of Naratriptan. |
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V71215 | NAS-181 | 205242-62-2 | NAS-181 is a potent and specific rat serotonin 1B (r5-HT1B) antagonist (inhibitor) with a Ki of 47 nM. |
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