In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71161 | PNU-96415E | 170856-41-4 | PNU-96415E is a selective D4/5-HT2A antagonist. |
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V71744 | Pramipexole-d5 (pramipexole-d5; Mirapa-d5) | 1217975-28-4 | Pramipexole-d5 is the deuterated form of Pramipexole. |
|
V71746 | Pramipexole-d7-1 dihydrochloride (pramipexole hydrochloride-d7-1; mirapax hydrochloride-d7-1) | 2702798-58-9 | Pramipexole-d7-1 (di-HCl) is the deuterated form of Pramipexole di-HCl. |
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V85299 | Preclamol ((-)-3-PPP) | 85966-89-8 | |
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V71779 | Preclamol hydrochloride ((-)-3-PPP hydrochloride) | 88768-67-6 | Preclamol HCl ((-)-3-PPP HCl) is a selective dopamine autoreceptor agonist (activator). |
|
V71750 | Propionylpromazine | 3568-24-9 | Propionylpromazine is a dopamine receptor DRD2 |
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V71722 | Propionylpromazine hydrochloride (Propionylpromazine hydrochloride) | 7681-67-6 | Propionylpromazine HCl (Propiopromazine HCl) is a dopamine receptor D2 (DRD2) antagonist used in Parkinson's disease (PD) research. |
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V71751 | Propionylpromazine-d6 hydrochloride (propionylpromazine d6 hydrochloride) | 1262770-67-1 | Propionylpromazine-d6 ( HCl) is the deuterium labelled form of Propionylpromazine HCl. |
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V102262 | Prosulpride | 68556-59-2 | Prosupride (GRI 1665) is a neuroleptic that selectively blocks dopamine receptors. |
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V71204 | PZ-1190 | 1852517-78-2 | PZ-1190 is a multi-target ligand of rodent serotonin and dopamine receptors with potential antipsychotic activity. |
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V71219 | Quetiapine hemifumarate-d8 (Quetiapine hemifumarate-d8) | 1435938-24-1 | Quetiapine (hemifumarate)-d8 is the deuterated form of Quetiapine hemifumarate. |
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V71777 | Raclopride-d5 hydrochloride (raclopride d5 (hydrochloride)) | 1217623-85-2 | Raclopride-d5 ( HCl) is the deuterated form of Raclopride. |
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V84174 | Risperidone-d6 (Risperidone-d6; R 64 766-d6) | 1225444-65-4 | |
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V71764 | RMI-61140 | 24140-98-5 | RMI-61140 is an orally bioactive neuroleptic agent. |
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V71765 | Ropinirole-d3 hydrochloride (SKF 101468-d3 hydrochloride) | 1329611-00-8 | Ropinirole-d3 ( HCl) is the deuterated form of Ropinirole HCl. |
|
V71772 | Ropinirole-d7 hydrochloride (SKF 101468-d7 hydrochloride) | 1261396-31-9 | Ropinirole-d7 ( HCl) is the deuterated form of Ropinirole HCl. |
|
V69999 | Roxindole hydrochloride (EMD 38362) | 108050-82-4 | Roxindole HCl, an indole alkylpiperidine, is a potent agonist of dopamine autoreceptors with affinity for the D2-like isoform in the low nanomolar range. |
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V106032 | S-Secoantioquine | 93767-29-4 | S-Secoantioquine (Secantioquine) is a ring-opened derivative of bisbenzylisoquinoline alkaloids. In the rat striatal membrane experiment, S-Secoantioquine has a weak displacement activity on the 3H-SCH 23390 binding site, but has a certain displacement activity on the 3H-raclopride binding site. |
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V96794 | Sarizotan dihydrochloride | 177976-12-4 | Salizoltan dihydrochloride (EMD 128130) is an orally active 5-HT1A receptor and dopamine receptor agonist with IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively. |
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V4610 | SB-277011 Dihydrochloride | 1226917-67-4 | SB-277011 dihydrochloride (also known as SB-277011A diHCl) is a novel, potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0,<5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. |
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