In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71762 | PD 168568 | 210688-56-5 | PD 168568 is an orally bioavailable dopamine receptor D4 (DRD4) antagonist. |
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V4808 | PD-168077 maleate | 630117-19-0 | PD-168077 maleate, the maleate salt of PD168077, is a novel, potent, centrally active and selective dopamine D4 receptor agonist with a Ki of 9 nM. |
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V1270 | Penfluridol (R-16341) | 26864-56-2 | Penfluridol (formerly TLP-607; McN-JR-16341; R-16341; Acemap; Semap)is a 1st generation, long-acting and diphenylbutylpiperidine-based antipsychotic medication used for maintenance/long-term treatment of schizophrenia or other psychotic disorders. |
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V1268 | Pergolide Mesylate (LY127809) | 66104-23-2 | Pergolide Mesylate (Permax; Pergotoliderived; LY127809; LY-127809), the mesylate salt of Pergolide, is a novel and potent antiparkinsonian agent which acts as a dopaminergic agonist. |
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V2706 | Perphenazine | 58-39-9 | Perphenazine (also known as Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
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V50934 | Perphenazine-d4 | 155593-75-2 | Perphenazine-d4 is the deuterium labeled Perphenazine. |
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V4441 | PF-06256142 | 1609583-14-3 | PF-06256142 is a novel, potent and selective orthosteric agonist of the D1 receptor with D1 EC50of 30 nM and D1 binding Kiof 12 nM. |
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V1256 | Phenothiazine (NSC2037; ENT38) | 92-84-2 | Phenothiazine (NSC 2037; ENT38; ENT 38; NSC-2037) is a potent dopamine-2 (D2) receptor antagonist used as antipsychotic medications for the treatment of schizophrenia and manifestations of psychotic disorders. |
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V18902 | Pimozide | 2062-78-4 | Pimozide (R-6238; NSC-170984; Orap) is an antipsychotic drug of the diphenylbutylpiperidine class discovered y Janssen Pharmaceuticals in 1963. |
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V71773 | PNU-177864 | 250266-51-4 | PNU-177864 is a specific, orally bioactive dopamine D3 receptor antagonist. |
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V71161 | PNU-96415E | 170856-41-4 | PNU-96415E is a selective D4/5-HT2A antagonist. |
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V0046 | Pramipexole (SND-919) | 104632-26-0 | Pramipexole (also known as SND 919; (S)-Pramipexole), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class. |
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V28566 | Pramipexole 2HCl ((S)-Pramipexole HCl) | 104632-25-9 | Pramipexole 2HCl (also known as SND 919; (S)-Pramipexole HC), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class that is used for the treatment of Parkinsons disease (PD) and restless legs syndrome (RLS). |
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V1261 | Pramipexole 2HCl Monohydrate | 191217-81-9 | Pramipexole 2HCl monohydrate (formerly known as SND 919; (S)-Pramipexole; trade name Mirapex among others) is the dihydrochloride salt and hydrated form of of pramipexole which isa potent agonist of the Gαi-linked dopamine receptors D2, D3, and D4 with neuroprotective effects. |
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V71744 | Pramipexole-d5 (pramipexole-d5; Mirapa-d5) | 1217975-28-4 | Pramipexole-d5 is the deuterated form of Pramipexole. |
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V71746 | Pramipexole-d7-1 dihydrochloride (pramipexole hydrochloride-d7-1; mirapax hydrochloride-d7-1) | 2702798-58-9 | Pramipexole-d7-1 (di-HCl) is the deuterated form of Pramipexole di-HCl. |
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V85299 | Preclamol ((-)-3-PPP) | 85966-89-8 | |
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V71779 | Preclamol hydrochloride ((-)-3-PPP hydrochloride) | 88768-67-6 | Preclamol HCl ((-)-3-PPP HCl) is a selective dopamine autoreceptor agonist (activator). |
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V2707 | Prochlorperazine dimaleate salt | 84-02-6 | Prochlorperazine dimaleate (also known as Prochlorperazin, Compazine, Capazine, Stemetil), the dimaleate salt ofProchlorperazine, is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. |
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V71750 | Propionylpromazine | 3568-24-9 | Propionylpromazine is a dopamine receptor DRD2 |
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