In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71722 | Propionylpromazine hydrochloride (Propionylpromazine hydrochloride) | 7681-67-6 | Propionylpromazine HCl (Propiopromazine HCl) is a dopamine receptor D2 (DRD2) antagonist used in Parkinson's disease (PD) research. |
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V71751 | Propionylpromazine-d6 hydrochloride (propionylpromazine d6 hydrochloride) | 1262770-67-1 | Propionylpromazine-d6 ( HCl) is the deuterium labelled form of Propionylpromazine HCl. |
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V71204 | PZ-1190 | 1852517-78-2 | PZ-1190 is a multi-target ligand of rodent serotonin and dopamine receptors with potential antipsychotic activity. |
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V71219 | Quetiapine hemifumarate-d8 (Quetiapine hemifumarate-d8) | 1435938-24-1 | Quetiapine (hemifumarate)-d8 is the deuterated form of Quetiapine hemifumarate. |
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V34121 | rac-Rotigotine Hydrochloride | 102120-99-0 | rac-Rotigotine Hydrochloride is the racemic mixture of Rotigotine (N-0437; N-0923), which is a potent, non-selective and dopamine receptor full agonist, used in the treatment of Parkinson's disease and restless legs syndrome. |
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V29135 | Raclopride (FLA-870) | 84225-95-6 | Raclopride (formerly FLA 870) is a novel, potent and selective dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. |
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V4975 | Raclopride tartrate | 98185-20-7 | Raclopride (formerly also known as FLA 870) is a novel, potent and selective dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. |
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V71777 | Raclopride-d5 hydrochloride (raclopride d5 (hydrochloride)) | 1217623-85-2 | Raclopride-d5 ( HCl) is the deuterated form of Raclopride. |
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V84174 | Risperidone-d6 (Risperidone-d6; R 64 766-d6) | 1225444-65-4 | |
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V71764 | RMI-61140 | 24140-98-5 | RMI-61140 is an orally bioactive neuroleptic agent. |
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V8750 | Ropinirole (SKF-101468) | 91374-21-9 | Ropinirole HCl (formerly SKF 101468; SKF-101468A; SKF 101468A; Requip), the hydrochloride salt of ropinirole, is a potent and selective dopamine D2 receptors agonist ( Ki = 29 nM) of the non-ergoline class of medications used for PD-Parkinson's disease, RLS/restless legs syndrome and extrapyramidal symptoms. |
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V1265 | Ropinirole HCl | 91374-20-8 | Ropinirole HCl (formerly SKF 101468; SKF-101468A; SKF 101468A; Requip), the hydrochloride salt of ropinirole, is a potent and selective dopamine D2 receptors agonist ( Ki = 29 nM) of the non-ergoline class of medications used for PD-Parkinson's disease, RLS/restless legs syndrome and extrapyramidal symptoms. |
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V71765 | Ropinirole-d3 hydrochloride (SKF 101468-d3 hydrochloride) | 1329611-00-8 | Ropinirole-d3 ( HCl) is the deuterated form of Ropinirole HCl. |
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V71772 | Ropinirole-d7 hydrochloride (SKF 101468-d7 hydrochloride) | 1261396-31-9 | Ropinirole-d7 ( HCl) is the deuterated form of Ropinirole HCl. |
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V1253 | Rotigotine (N-0437; N-0923) | 99755-59-6 | Rotigotine(formerly N-0437; N-0923; N0437; N0923; trade names Neupro among others) is a potent, non-selectivefull agonist of dopamine receptor that has been approved for use in the treatment of PD/Parkinsons disease and restless legs syndrome. |
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V14007 | Rotigotine Hydrochloride | 125572-93-2 | RotigotineHydrochloride (N-0437; N-0923) is a potent, non-selective and dopamine receptor full agonist, used in the treatment of Parkinsons disease and restless legs syndrome. |
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V1264 | Rotundine | 483-14-7 | Rotundine (also called L-THP or L-tetrahydropalmatine) is a naturally occuring alkaloid isolated from Corydalis rhizoma (a traditional Chinese medicinal plant) with analgesic activity. |
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V69999 | Roxindole hydrochloride (EMD 38362) | 108050-82-4 | Roxindole HCl, an indole alkylpiperidine, is a potent agonist of dopamine autoreceptors with affinity for the D2-like isoform in the low nanomolar range. |
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V4610 | SB-277011 Dihydrochloride | 1226917-67-4 | SB-277011 dihydrochloride (also known as SB-277011A diHCl) is a novel, potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0,<5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. |
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V71124 | SB-277011 hydrochloride (SB-277011A hydrochloride) | 215804-67-4 | SB-277011 HCl (SB-277011A HCl) is a specific, orally bioavailable and brain-penetrating dopamine D3 receptor (D3R) antagonist (inhibitor) with Kis of 10.7 nM and 10.7 nM in rodents and human D3R, respectively. |
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