In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V101737 | (+)-Butaclamol hydrochloride | 55528-07-9 | (+)-Butalamol hydrochloride is a neuroleptic with dopamine receptor blocking activity. |
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V84344 | (+)-UH 232 (UH 232) | 95999-12-5 | |
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V19599 | (-)-Quinpirole HCl | 85798-08-9 | Quinpirole HCl [(-)-LY 171555] is a highly potent psychoactive drug and research chemical which acts as a high affinity and selective D₂ and D₃ receptor agonist. |
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V71727 | (R)-Preclamol ((+)-3-PPP) | 85976-54-1 | (R)-Preclamol is a dopamine (DA) agonist/activator with autoreceptor and postsynaptic receptor stimulating properties. |
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V71759 | (R)-Preclamol hydrochloride ((+)-3-PPP hydrochloride) | 89874-80-6 | (R)-Preclamol HCl ((+)-3-PPP HCl) is the R-enantiomer of Preclamol HCl. |
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V101190 | (R)-SKF-81297 hydrobromide | 253446-15-0 | (R)-SKF-81297 hydrobromide is the R isomer of SKF-81297. |
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V71721 | (Rac)-PF-06256142 | 1609580-97-3 | (Rac)-PF-06256142 is the weaker enantiomer of PF-06256142. |
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V71728 | (Rac)-Razpipadon (PW0464) | 1643462-93-4 | PW0464 is a full G protein ligand with nanomolar activity and an agonist of D1R with EC50 of 5.8 nM (Gs-cAMP). |
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V71221 | (Rac)-Rotigotine (N-0437) | 92206-54-7 | (Rac)-Rotigotine (N-0437) is the racemate of Rotigotine. |
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V71718 | (Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) | 1643462-64-9 | (Rac)-Tavapadon ((Rac)-PF-06649751) is a specific, non-catecholic dopamine D1 receptor agonist. |
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V101474 | 7-Hydroxy-PIPAT | 159559-71-4 | 7-Hydroxy-PIPAT (Compound 2) is a D3R agonist. |
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V1260 | Paliperidone | 144598-75-4 | Paliperidone (Invega; Invega Sustenna; Invega Sustenna; 9-hydroxyrisperidone), the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist used for the treatment of schizophrenia. |
![[18F]-Labeled L-dopa precursor](http://www.invivochem.com/upload/1124/V71732.png)
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V71732 | [18F]-Labeled L-dopa precursor | 1614253-58-5 | [18F]-Labeled L-dopa precursor is a precursor used to synthesize 18F-labeled L-dopa. |
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V9846 | A-381393 | 726174-00-1 | A-381393 is a potent, selective, BBB (blood-brain barrier) permeable/penetrable dopamine D4 receptor blocker (antagonist) with Kis of 1.5, 1.9 and 1.6 for human dopamine D4.4, D4.2 and D4.7 receptors respectively. |
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V71753 | A-412997 dihydrochloride | 1347744-96-0 | A-412997 di-HCl is a selective dopamine D4 receptor agonist that improves cognitive performance in rats. |
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V71745 | A-77636 | 778546-51-3 | A-77636 is an orally bioactive, selective, long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). |
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V71716 | A68930 hydrochloride | 130465-39-3 | A68930 HCl, as a dopamine D1 receptor agonist (activator), may be utilized in the research/study of bronchiectasis. |
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V40042 | ABT-724 trihydrochloride | 587870-77-7 | ABT-724 trihydrochloride is a novel, potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM. |
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V9995 | ABT-724 | 70006-24-5 | ABT-724 isa novel,potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM. |
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V101342 | Acein | 2022202-76-0 | Acein is a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. |
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