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GnRH Receptor

GnRH Receptor

The rhodopsin-like G protein-coupled receptor (GPCR) family includes the gonadotropin-releasing hormone receptor (GNRHR), which is made up of seven transmembrane helical domains connected by extracellular and intracellular segments. Gonadotrophs, pituitary cells that produce the gonadotrophins LH and FSH, have a GnRH receptor on their plasma membrane.

Different ligand preferences for GnRH-I and GnRH-II are shown by mammalian type I and type II GnRH receptors, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which in turn activates the production of second messengers that in turn activates protein kinase C (PKC) through the phospholipase C pathway. LH and FSH are produced and released more quickly when the GnRH receptor is activated by GnRH analogues. GnRH receptors have a variety of medical and veterinary applications, including the study of breast and prostate cancer, the control of fertility, endometriosis, and other conditions.

GnRH Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH V75391 (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH 1926163-38-3 (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analog of luteinizing hormone-releasing hormone (LHRH).
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH V75392 (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 1926163-39-4 (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analog of luteinizing hormone-releasing hormone (LHRH).
(D-Trp6)-LHRH free acid V75393 (D-Trp6)-LHRH free acid 129418-54-8 (D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist.
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH V75390 (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH 1426173-74-1 (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analog of luteinizing hormone-releasing hormone (LHRH).
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) V60341 (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) 88848-87-7 (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) is a GnRH analog that induces ovulation and/or spawning in farmed fish.
(R)-BAY-899 V77381 (R)-BAY-899 2988191-40-6 (R)-BAY-899 is the R-isomer of BAY-899.
[D-Ala6]-LH-RH V75389 [D-Ala6]-LH-RH 51230-19-4 [D-Ala6]-LH-RH is a luteinizing hormone-releasing hormone (LHRH) analog that works as a GnRH receptor agonist (activator).
[D-Arg6,Pro9-NEt]Salmon gonadotropin-releasing hormone V40902 [D-Arg6,Pro9-NEt]Salmon gonadotropin-releasing hormone 96497-82-4 sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analog.
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH V75397 [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH 68059-94-9 [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a luteinizing hormone-releasing hormone (LHRH) analog that works as a GnRH receptor blocker (antagonist).
[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide V77475 [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide is a bioactive peptide analog of LHRH.
[D-Lys6]-LH-RH V75402 [D-Lys6]-LH-RH 52671-12-2 [D-Lys6]-LH-RH is a luteinizing hormone-releasing hormone (LHRH) analog that works as a GnRH receptor agonist (activator).
Abarelix Acetate (Abarelix Acetate; PPI 149 Acetate; R 3827 Acetate) V75385 Abarelix Acetate (Abarelix Acetate; PPI 149 Acetate; R 3827 Acetate) 547741-72-0 Abarelix (R3827) Acetate is a potent gonadotropin-releasing hormone (GnRH) antagonist utilized in study/research of prostate cancer.
Acyline TFA V77290 Acyline TFA Acyline TFA, a GnRH peptide analog, is a GnRH antagonist that suppresses gonadotropin and testosterone (T) levels.
Azaline B V86629 Azaline B 134457-28-6 Azaline B is a gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 1.37 nM.
BAY-298 V75386 BAY-298 2471978-97-7 BAY-298 is an orally bioactive and selective luteinizing hormone receptor (LH-R) antagonist (inhibitor) with IC50 for hLH (human LH), rLH (rat LH) and cLH (cynomolgus monkey LH), respectively.
BAY-899 V75384 BAY-899 2471967-92-5 BAY-899 is an orally potent and specific luteinizing hormone receptor (LH-R) antagonist (inhibitor) with IC50s of 185 nM and 46 nM for hLH (human LH) and rLH (rat LH), respectively.
DCOIT (Kathon 930) V84733 DCOIT (Kathon 930) 64359-81-5
Fsh receptor-binding inhibitor fragment(bi-10) V75399 Fsh receptor-binding inhibitor fragment(bi-10) 163973-98-6 FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist.
GnRH antagonist 2 V51369 GnRH antagonist 2 1709823-61-9 GnRH antagonist 2 (formula I) is a GnRH receptor blocker (antagonist) that may be utilized in the research/study of endometriosis.
GnRH Associated Peptide (1-24), human (GAP (1-24), human) V75396 GnRH Associated Peptide (1-24), human (GAP (1-24), human) 148943-65-1 GnRH Associated Peptide (GAP) (1-24), human is the 1-24 fragment of human gonadotropin-releasing hormone-related peptide (GAP) (hGAP-1-24).
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