A family of powerful bioactive lipids known as leukotriene receptors (cys-LTs) act through two structurally distinct G protein-coupled receptors known as the CysLT1 and CysLT2 receptors. Important mediators of human bronchial asthma include the cysteinyl leukotrienes LTC4, LTD4, and LTE4. The second messenger system that the leukotriene receptor uses is phosphatidylinositol-calcium. It belongs to the superfamily of G protein-coupled receptors. When LTD4 activates CysLT1, smooth muscle contracts and grows more, there is oedema, eosinophil migration, and lung mucus layer damage. LTRAs, or leukotriene receptor antagonists, are a class of non-steroidal oral medications. They may also be known as bronchoconstriction preventors with anti-inflammatory properties. LTRAs function by preventing a chemical process that can result in airway inflammation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V104510 | LTD4 antagonist 2 | 107813-86-5 | LTD4 antagonist 2 (Compound 6) is a leukotriene D4 (LTD4) antagonist with IC50 of 2.8 μM for cysteine leukotriene 1 receptor (CysLT1R). |
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V4326 | MK-571 sodium | 115103-85-0 | MK-571 sodium (L-660711; MK571) is a novel, potent, selective, orally bioactive antagonist of leukotriene D4 (LTD4) receptor with the potential to be used for pulmonary hypertension. |
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V75428 | Montelukast-d6 (MK0476-d6 (free acid)) | 1093746-29-2 | Montelukast-d6 is the deuterium labelled form of Montelukast. |
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V75426 | Montelukast-d6 sodium (MK0476-d6) | 2673270-26-1 | Montelukast-d6 (sodium) is the deuterated form of Montelukast (sodium). |
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V86655 | Ontazolast | 147432-77-7 | Ontazolast (BIRM 270) is a potent inhibitor of LTB4 biosynthesis. |
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V75427 | Piriprost potassium (U 60257B) | 88851-62-1 | Piriprost (U-60,257B) potassium is a leukotriene synthesis inhibitor. |
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V94677 | Pirodomast | 108310-20-9 | Pirodomast (Sch 37224) is an inhibitor of leukotriene formation. |
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V96636 | Pobilukast | 107023-41-6 | Pobilukast is a classic CysLT1 receptor antagonist and can be used in asthma research. |
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V94935 | REV 5901 hydrochloride | 92532-23-5 | REV 5901 hydrochloride is an orally active competitive leukotriene receptor antagonist with Ki of 0.7 μM. |
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V85624 | Ritolukast (Wy-48252) | 111974-60-8 | |
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V103125 | SR2640 | 105350-26-3 | SR2640 is a highly potent and selective LTD4/LTE4 antagonist that can specifically inhibit LTD4-induced contraction of guinea pig ileum and tracheal smooth muscle in a concentration-dependent manner without affecting the contractile response induced by histamine. |
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V106023 | Torososide B | 243835-63-4 | Torososide B is an antiallergic compound that inhibits calcium ionophore A-induced leukotriene release from rat peritoneal mast cells. |
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V85038 | Triptinin B | 189389-05-7 | |
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V75429 | Verlukast-d6 (MK-679-d6; L 668019-d6) | 153698-86-3 | Verlukast-d6 is the deuterium labelled form of Verlukast. |
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V102992 | Zafirlukast metabolite M1 | 219583-10-5 | Zafirlukast metabolite M1 (compound 15) is an inhibitor of allergic lung diseases such as asthma and can antagonize the activity of leukotrienes. |
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V75435 | Zafirlukast-d7 (Zafirlukast d7) | 1217174-18-9 | Zafirlukast-d7 is the deuterated form of Zafirlukast. |
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V75434 | γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) | 31450-14-3 | γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is an antagonist of leukotriene B receptor 4 (LTB4). |
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V2451 | Olsalazine Sodium (CJ-91B) | 6054-98-4 | Olsalazine Sodium (CJ-91B) is a potent anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond. |
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V41728 | Montelukast Dicyclohexylamine | 577953-88-9 | Montelukast (MK0476) dicyclohexylamine is a potent, selective and orally bioactive cysteine leukotriene receptor 1 (CysLT1) antagonist. |
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V4387 | MONTELUKAST SODIUM (MK0476) | 151767-02-1 | Montelukast sodium (also known as MK-476; trade names Singulair; Monteflo; Lukotas; Lumona) is a novel, potent, selective CysLT1 (leukotriene receptor) receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. |
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