The acetylcholine receptors known as mAChRs (muscarinic acetylcholine receptors) are found in the cell membranes of some neurons and other cells. The primary end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system is one of their many functions. Because they are more sensitive to muscarine than to nicotine, mAChRs are so named. Nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also significant in the autonomic nervous system, are their counterparts. Numerous medications and other substances, such as scopolamine and pilocarpine, act as selective agonists or antagonists on these two different receptors. The brain and the autonomic ganglia are both rich sources of the neurotransmitter acetylcholine (ACh).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78404 | Umeclidinium-d5 bromide (GSK573719A-d5) | Umeclidinium-d5 (bromide) is the deuterated form of Umeclidinium bromide. | |
|
V81742 | VLVNTFCDSCIPKTYWNLGY TFA | VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of the M3 muscarinic receptor (M3R). | |
|
V20318 | VU0119498 | 79183-37-2 | VU0119498 is a positive allosteric modulator (PAM) of pan-Gq mAChR M1, M3, and M5 with EC50s of 6.04, 6.38, and 4.08 µM, respectively. |
|
V2229 | VU0238441 | 85511-68-8 | VU0238441 is a pan-muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50 of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM and > 10 for M1, M2, M3, M5 and M4, respectively. |
|
V3036 | VU0357017 HCI | 1135242-13-5 | VU0357017 HCI (formerly CID-25010775) is a potent and highly selective M1 agonists that appear to act at an allosteric site to activate the receptor with EC50 of 477 ± 172 nM and pEC50 of 6.37 ± 0.15). |
|
V28096 | VU0453595 | 1432436-13-9 | VU0453595 is a selective, systemically active M1 positive allosteric modulator (PAM) (PAM, EC50=2140 nM) that may be utilized in the research/study of schizophrenia. |
|
V70505 | VU10010 | 633283-39-3 | VU10010 is a specific allosteric enhancer of M4 mAChR with EC50 of 400 nM. |
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V70523 | VU6000918 | 2101737-32-8 | VU6000918 is a positive allosteric modulator (PAM) of muscarinic acetylcholine (M4) with EC50 of 19 nM for hM4. |
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V70503 | VU6019650 | 2926782-31-0 | VU6019650 is a potent and specific positive M5 mAChR antagonist (IC50=36 nM) that may be utilized in studies to alleviate opioid use disorder (OUD). |
|
V84261 | VU6021625 | 2803696-99-1 | |
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V70512 | W-84 dibromide (HDMPPA) | 21093-51-6 | W-84 (dibromide) is a strong allosteric modulator of M2-cholinoceptors, which blocks [3H]N-methylscopolamine dissociation. |
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V70499 | Xanomeline (LY-246708) | 131986-45-3 | Xanomeline increases neuronal excitability as a potent and specific muscarinic type 1 and 4 (M1/M4) receptor agonist. |
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V4900 | Xanomeline oxalate | 141064-23-5 | Xanomeline oxalate (also known as LY246708) is a novel, potent and selective M1 muscarinic receptor agonistwith good selectivity for the M1 and M4 subtypes. |
|
V70521 | YM-58790 free base | 168830-70-4 | YM-58790 free base is a potent mAChR antagonist. |
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V70520 | β2AR agonist /M-receptor antagonist-1 | 2772700-36-2 | β2AR agonist/M-receptor antagonist-1 is a potent muscarinic antagonist/β2 agonist (MABA). |
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V70524 | β2AR/M-receptor agonist-1 | 2230520-62-2 | β2AR/M-receptor agonist-1 (example 131) is a muscarinic antagonist and β2-adrenoceptor agonist (MABA). |
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