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V70614
|
CVN636
|
2226732-62-1 |
CVN636 is an orally bioactive, selective mGluR7 allosteric agonist/activator with EC50 of 7 nM for hu mGluR7. |
|
V70620
|
Desmethyl-YM-298198 hydrochloride
|
1177767-57-5 |
Desmethyl-YM-298198 HCl is a high-affinity, selective, noncompetitive mGluR1 antagonist (IC50= 16 nM). |
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V70626
|
DMeOB (3,3'-Dimethoxybenzaldazine)
|
40252-74-2 |
DMeOB is an agonist of mGluR5 receptor with IC50 of 3 μM. |
|
V4895
|
Eglumegad
|
176199-48-7 |
Eglumegad (also known as LY-354740) is a novel, highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. |
|
V77047
|
Eglumegad hydrochloride (LY354740 hydrochloride; Eglumetad hydrochloride)
|
|
Eglumegad (LY354740) HCl is a potent and specific group II (mGlu2/3) receptor agonist/activator with IC50 of 5 and 24 nM for human mGlu2 and mGlu3 receptors, respectively. |
|
V83401
|
Fenobam hydrate
|
63540-28-3 |
|
|
V21041
|
FITM
|
932737-65-0 |
FITM is a negative allosteric modulator (NAM) of the mGlu1 receptor with Ki of 2.5 nM. |
|
V3325
|
FPTQ
|
864863-72-9 |
FPTQ is novel and potent antagonist of mGluR1 (metabotropic glutamate receptor subtype 1) with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. |
|
V3356
|
FTIDC
|
873551-53-2 |
FTIDC is a novel, orally bioactive, highly potent and selective negative allosteric modulator/antagonist of metabotropic glutamate receptor (mGluR) 1 with anxiolytic and antipsychotic effects. |
|
V50980
|
HexylHIBO
|
334887-43-3 |
HexylHIBO is a type I mGluR antagonist (inhibitor) with Kb values of 140 and 110 μM at mGlu1a and mGlu5a receptors. |
|
V70625
|
IEM-1925 bromide
|
258282-23-4 |
IEM-1925 bromide is an orally bioactive glutamate receptor antagonist that increases latency and reduces ongoing symptoms such as epilepsy in rat models. |
|
V70612
|
JF-NP-26
|
2341841-03-8 |
JF-NP-26 is an inactive photocaged analogue of Raseglurant and the first NAM (negative allosteric modulator) of photocaged mGlu5 receptors. |
|
V3326
|
JNJ-16259685
|
409345-29-5 |
JNJ16259685 (JNJ-16259685) is a novel, potent, selective and non-competitive antagonist of mGlu1 receptor with IC50 of 19 nM. |
|
V2921
|
JNJ-40411813
|
1127498-03-6 |
JNJ-40411813 (formerly known as ADX71149) is a novel positive allosteric modulator of the mGlu2R receptor (metabotropic Glutamate 2 receptor) with EC50 of 147 nM. |
|
V2844
|
JNJ-42153605
|
1254977-87-1 |
JNJ-42153605 is a potent, selective and allosteric modulator of the mGlu2 (metabotropic glutamate 2) receptor with with an EC50 of 17 nM. |
|
V4511
|
JNJ-46778212
|
1363281-27-9 |
JNJ-46778212 (also known as VU 0409551) is a novel, potent,orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu5)positive allosteric modulator (PAMs) with anEC50of 260 nM. |
|
V50939
|
L-AP3
|
23052-80-4 |
L-AP3, a metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively. |
|
V70608
|
L-AP4 monohydrate (L-APB monohydrate)
|
2247534-79-6 |
L-AP4 (L-APB) monohydrate is a potent, specific agonist of metabotropic glutamate receptors (mGluR) with EC50s of 0.13, 0.29 for mGlu4, mGlu8, mGlu6 and mGlu7 receptors respectively. |
|
V70603
|
L-CCG-I
|
117857-93-9 |
L-CCG-I is an expanded isomer of a conformationally restricted glutamate analogue. |
|
V84745
|
LBG30300
|
|
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