| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V16769 | LSN2463359 | 1401031-52-4 | LSN-2463359 is a novel and potent PAM/positive allosteric modulator of metabotropic glutamate 5 (mGlu5). |
|
V4655 | Lu AF21934 | 1445605-23-1 | Lu AF21934 is a novel, potent, selective and brain-penetrant positive allosteric modulator of mGlu4 receptors with an IC50 of 500 nM for human mGlu4 |
|
V24476 | Lu AF32615 | 125404-04-8 | TCN238 is an orally bioavailable positive allosteric modulator (PAM) of the mGlu4 receptor with EC50 of 1 μM. |
|
V4867 | LY-341495 | 201943-63-7 | LY 341495 is a novel, potent and selective orthosteric antagonist of the metabotropic glutamate receptors (mGluR) with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively. |
|
V70602 | LY3020371 | 1377615-75-2 | LY3020371 is a potent and specific glutamate receptor (mGluR2/3) antagonist (inhibitor) with Kis of 5.26 and 2.50 nM for hmGluR2 and hmGluR3, respectively. |
|
V70604 | LY3027788 | 1377615-76-3 | LY3027788 is a diester analog of LY3020371, an antagonist of mGlu2/3 receptor, and a potent orally bioactive prodrug of LY3020371. |
|
V70605 | LY3027788 hydrochloride | 1377615-55-8 | LY3027788 HCl is a diester analog of LY3020371, an antagonist of mGlu2/3 receptor, and a potent orally bioactive prodrug of LY3020371. |
|
V70593 | LY367385 hydrochloride | 2829282-00-8 | LY367385 HCl is a highly efficient and selective mGluR1a antagonist, with IC50 of 8.8 μM for inhibiting quinquinoline-induced hydrolysis of phosphoinositide, while the IC50 for mGlu5a is greater than 100 μM. |
|
V14550 | LY487379 HCl | 353229-59-1 | LY-487379 is a novel, potent and selective PAM (positive allosteric modulator) for the metabotropic glutamate receptor group II subtype mGluR2. |
|
V70624 | MCPG sodium | 1303994-09-3 | MCPG is a carboxyphenylglycine. |
|
V4662 | MFZ 10-7 | 1224431-15-5 | MFZ 10-7 is a selective mGluR5 negative allosteric modulator (NAM) with Ki of 0.67 nM for rat mGluR5. |
|
V83371 | mGluR2 agonist 1 hydrochloride | ||
|
V70600 | mGluR2 antagonist 1 | 1432728-49-8 | mGluR2 antagonist 1 is an orally bioactive, BBB (blood-brain barrier) permeable/penetrable, selective negative allosteric modulator (NAM) of mGluR2 (IC50 is 9 nM). |
|
V70623 | mGluR3 modulator-1 | 374548-18-2 | mGluR3 modulator-1 (compound 3) is a modulator of mGluR3 with EC50 of 1-10 μM measured in the HEK293T-mGluR-Gqi5 calcium motility assay. |
|
V70618 | mGluR5 antagonist-1 | 2761424-76-2 | mGluR5antagonist-1 is a high-affinity mGluR5 antagonist (inhibitor) with IC50 of 11.5 nM. |
|
V70622 | mGluR5 modulator 1 | 1261171-52-1 | mGluR5 modulator 1 is a PAM (positive allosteric modulator) of mGluR5. |
|
V70601 | MGS0274 | 1501974-69-1 | MGS0274 is a lipophilic precursor of the mGlu2 and mGlu3 receptor agonist MGS0008, which improves oral bioavailability (F). |
|
V70631 | MK-8768 | 1432729-22-0 | MK-8768 is an orally bioactive, BBB (blood-brain barrier) permeable/penetrable, selective mGluR2 negative allosteric modulator (NAM) (IC50 of 9 nM). |
|
V2285 | ML 254 | 1428630-86-7 | ML254 is a potent mGlu5 enhancer with EC50 and pEC50 of 9.3 nM for mouse mGlu5. |
|
V76761 | ML353 | ML353 is a selective ligand for the mGlu5 silent allosteric modulator (SAM) with a Ki of 18.2 nM. |
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