The G protein-coupled receptor superfamily includes several subtypes of neuropeptide Y receptors. The terms Y1, Y2, Y4, Y5, and Y6 refer to the five cloned NPY receptor subtypes in mammals. Vasoconstriction and feeding are two physiological responses that are mediated by neuropeptide Y receptors.
Humans express the Y1, Y2, Y4, and Y5 subtypes. They are primarily found in tissues like the cardiovascular system and the central and peripheral nervous systems. The neurotransmitter Neuropeptide Y, as well as the hormones peptide YY (PYY) and pancreatic polypeptide (PP), are their physiological ligands.
Important biological and pathophysiological processes like blood pressure, neuroendocrine secretions, seizures, neuronal excitability, and neuroplasticity are regulated by neuropeptide Y and its receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76990 | Galanin (1-29)(rat, mouse) TFA | Galanin (1-29)(rat, mouse) TFA is a non-selective galanin receptor agonist/activator with Kis of 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively. | |
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V79553 | Galanin (swine) (TFA) | Galanin (swine) TFA is a neuropeptide consisting of 29 amino acid (AA)s containing a C-terminal amidated glycine. | |
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V76989 | Galantide TFA | Galantide TFA is a reversible, non-specific galanin (GAL) receptor antagonist. | |
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V70823 | Galnon TFA | 1217448-19-5 | Galnon TFA is a selective, non-peptide galanin GAL1 and GAL2 receptor agonist/activator with Kis of 11.7 and 34.1 μM, respectively. |
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V51124 | GR-231118 (1229U-91; GW-1229) | 158859-98-4 | neuropeptide Y Y receptor antagonist |
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V79646 | GR231118 TFA (1229U91 TFA; GW1229 TFA) | GR231118 is a C-terminal analog of neuropeptide Y. | |
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V2783 | HT-2157 | 303149-14-6 | HT-2157 (also known as SNAP 37889) is a selective, high-affinity, and competitive antagonists of galanin-3 receptor (Gal3) that has the potential for the treatment of major depressive disorder. |
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V80319 | human GALP (3-32) (Galanin-like peptide (3-32)) | human GALP (3-32) (Galanin-like peptide (3-32)) is a potent galanin receptor agonist in competitive binding experiments against GalR1 (IC50=33 nM) and GalR2 (IC50=15 nM) Has high affinity. | |
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V2943 | JNJ-31020028 | 1094873-14-9 | JNJ-31020028 (JNJ31020028) is a potent, high-affinitiy, selective and brain penetrant small molecule antagonist of the neuropeptide Y(2) receptor with pIC50=8.07 (human); pIC50=8.22 (rat); it is >100-fold selective versus human Y1/Y4/Y5 receptors. |
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V70837 | Lu AA33810 | 304008-29-5 | Lu AA33810 is a potent and specific neuropeptide Y5 receptor antagonist (inhibitor) with a Ki of 1.5 nM for the human receptor. |
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V70842 | M1145 | 1172089-00-7 | M1145 is a selective galanin receptor type 2 (GAL2) agonist/activator with Ki of 6.55 nM. |
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V80655 | M1145 TFA | M1145 is a selective galanin receptor type 2 (GAL2) agonist/activator with Ki of 6.55 nM. | |
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V70826 | M617 | 860790-38-1 | M617 is a selective galanin receptor 1 (GAL1) agonist/activator with Ki of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. |
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V76800 | M617 TFA | M617 TFA is a selective galanin receptor 1 (GAL1) agonist/activator with Ki of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. | |
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V70835 | M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) | 908844-75-7 | M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 (GalR2) antagonist. |
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V4296 | MK-0557 | 328232-95-7 | MK-0557 (MK0557) is a novel, highly selective, orally bioavailable neuropeptide Y5 receptor antagonist with anti-obesity effects. |
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V70822 | Neuropeptide S(Mouse) | 412938-74-0 | Neuropeptide S (Mouse) is a biologically active peptide. |
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V80935 | Neuropeptide S(Mouse) TFA | Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50=3 nM). | |
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V70831 | Neuropeptide S(Rat) | 412938-75-1 | Neuropeptide S (Rat) is an endogenous ligand formerly known as the orphan G-protein-coupled receptor and now known as the NPS receptor. |
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V80936 | Neuropeptide S(Rat) TFA | Neuropeptide S(Rat) TFA is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC50=3.2 nM). |
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