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Opioid Receptor

Opioid Receptor

Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances. Opioid receptors prevent impulses from traveling along excitatory pathways in the human body.The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.

Opioid Receptor related products

Structure Cat No. Product Name CAS No. Product Description
LY255582 V69953 LY255582 119193-09-8 LY255582 is a pan-opioid antagonist (inhibitor) with high affinity for mu, delta and kappa receptors (Ki 0.4 nM, 5.2, 2.0 nM, respectively).
LY2795050 V4848 LY2795050 1346133-08-1 LY2795050 is a novel, potent and selective κ-opioid Receptor (KOR) antagonist with an IC50 of 0.72 nM.
LY2940094 V4864 LY2940094 1307245-86-8 LY-2940094 is a novel, potent, selective and orally bioavailable nociceptin receptor (NOP receptor) antagonist that can be potentially used for the treatment of major depressive disorder and alcoholism.
Meptazinol HCl V1280 Meptazinol HCl 59263-76-2 Meptazinol (IL-22811; WY-22811; IL22811; WY22811; trade name Meptid), the hydrochloride salt of meptazinol, is a centrally actiing opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM.
Methyl-6-alpha-Naltrexol V69896 Methyl-6-alpha-Naltrexol 116388-85-3 Methyl-6-alpha-Naltrexol is the metabolite of methylnaltrexone (MNTX).
Mitragynine pseudoindoxyl V69958 Mitragynine pseudoindoxyl 2035457-43-1 Mitragynine pseudoindoxyl is a potent MOR agonist.
MOR agonist-1 V69973 MOR agonist-1 2305781-14-8 MOR agonist-1 is a MOR (μ-opioid receptor) agonist.
MOR agonist-2 V80811 MOR agonist-2 MOR agonist-2 (Compound 46) is an antagonist of D3R and an agonist of MOR (Ki 7.26 nM and 564 nM respectively).
mu opioid receptor agonist 3 V69909 mu opioid receptor agonist 3 2378397-91-0 μ opioid receptor agonist 3 (compound 20) is a potent μ opioid receptor (μOR) agonist/activator with EC50 of 0.87 nM.
Mu opioid receptor antagonist 1 V69938 Mu opioid receptor antagonist 1 2767446-03-5 Mu opioid receptor antagonist 1 (compound 19) is a selective and orally bioactive mu opioid receptor (MOR) ligand with a Ki of 0.58 nM and EC50 of 1.15 nM.
Mu opioid receptor antagonist 2 V69910 Mu opioid receptor antagonist 2 2773925-64-5 Mu opioid receptor antagonist 2 (compound 25) is a specific and BBB (blood-brain barrier) permeable (penetrable) mu opioid receptor (MOR) antagonist (inhibitor) with a Ki of 0.37 nM and EC50 of 0.44 nM.
Mu opioid receptor antagonist 3 V69947 Mu opioid receptor antagonist 3 2773925-66-7 Mu opioid receptor antagonist 3 (compound 26) is a potent and specific mu opioid receptor (MOR) antagonist (inhibitor) with a Ki of 0.24 nM and EC50 of 0.54 nM.
Mu opioid receptor antagonist 4 V69948 Mu opioid receptor antagonist 4 2773925-74-7 Mu opioid receptor antagonist 4 (compound 31) is a potent and specific mu opioid receptor (MOR) antagonist (inhibitor) with EC50 of 1.07 nM and a Ki of 0.38 nM.
Mu opioid receptor antagonist 5 V69940 Mu opioid receptor antagonist 5 1124167-61-8 Mu opioid receptor antagonist 5 (compound NAP) is a selective and BBB (blood-brain barrier) permeable (penetrable) mu opioid receptor (MOR) antagonist (inhibitor) with EC50 of 1.14 nM and a Ki of 0.37 nM.
Mu opioid receptor antagonist 7 V69925 Mu opioid receptor antagonist 7 2378397-30-7 Mu opioid receptor antagonist 7 (compound 24) is a potent and CNS-permeable (penetrable) μOR (μ-opioid receptor) antagonist (inhibitor) with IC50 of 29 ± 3.0 nM.
N-Benzylnaltrindole hydrochloride V69921 N-Benzylnaltrindole hydrochloride 1206487-81-1 N-Benzylnaltrindole HCl is a potent delta 2-selective opioid receptor antagonist.
N-terminally acetylated Leu-enkephalin (Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH) V69976 N-terminally acetylated Leu-enkephalin (Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH) 2703746-32-9 N-terminally acetylated Leu-enkephalin is N-terminally acetylated Leu-enkephalin.
Naloxone methiodide V69884 Naloxone methiodide 93302-47-7 Naloxone methiodide is a peripherally restricted, non-selective and competitive opioid receptor blocker (antagonist).
Naloxone-d5 V69962 Naloxone-d5 1261079-38-2 Naloxone D5 is a deuterated compound standard of naloxone.
Naltrexone V69880 Naltrexone 16590-41-3 Naltrexone is an Opioid receptor antagonist.
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