As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78803 | Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40); Citrullinated Aβ40) | Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40)) is a modified form of β-Amyloid (1-40) that is citrullinated at the Arg5 site. | |
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V78804 | Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42); Citrullinated Aβ42) | Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) that is citrullinated at the Arg5 site. | |
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V71365 | Cl-NQTrp | 185351-23-9 | Cl-NQTrp significantly disrupts preformed fibrillar aggregates of tau-derived PHF6 (VQIVYK) peptide and full-length tau protein. |
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V71432 | Coumarinic acid | 495-79-4 | Coumarinic acid is a brain-penetrating inhibitor of AChE and β-amyloid. |
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V18783 | CRANAD-2 | 1193447-34-5 | CRANAD-2 is adifluoroboron-based curcumin acting as anear-infrared (NIR) Aβ plaque-specific fluorescent probe for in vivo detection of amyloid-beta deposits. |
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V71372 | Crenezumab (MABT 5102A; RG 7412) | 1095207-05-8 | Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody (mAb) that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, and may be used in AD/Alzheimer's disease study. |
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V71424 | Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) | 1802086-21-0 | Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) is a bioactive peptide fragment of amyloid β protein (Aβ). |
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V71379 | Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) | 1802078-25-6 | Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) is the 36-42 fragment of amyloid β protein. |
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V71377 | D-KLVFFA | 342877-55-8 | D-KLVFFA is an inhibitor (blocker/antagonist) of Amyloid-β assembly with IC50 of 2.6 μM. |
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V80071 | DDC 2′,3′-O-disulfate | DDC 2′,3′-O-disulfate (compound 4) prevents fibrillation and oligomerization of Aβ42. | |
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V15809 | Deferoxamine mesylate | 138-14-7 | Deferoxamine is an novel iron chelator that is able to bind to free iron in a stable complex, it is also a bacterial siderophore produced by the Actinobacteria Streptomyces pilosus. |
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V71362 | Direct Red 80 (Sirius Red; Sirius Red) | 2610-10-8 | Direct Red 80 (Sirius Red) is a polyazo dye primarily used in staining methods for collagen and amyloid. |
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V71358 | Donanemab (LY3002813) | 1931944-80-7 | Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody (mAb) directed against the N-terminal pyroglutamate amyloid-beta (Aβ) epitope. |
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V20400 | Edonerpic maleate | 519187-97-4 | Edonerpic, formerly known as T-817, is a neuroprotectant. |
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V1315 | EUK 134 | 81065-76-1 | EUK 134 (EUK-134; EUK134), a synthetic and cell permeable superoxide dismutase (SOD)/catalase mimetic, is a novel antioxidant compound that exhibits potent antioxidant activities. |
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V71409 | FITC-β-Ala-Amyloid β-Protein (1-42) | 1802087-77-9 | FITC-β-Ala-Amyloid β-Protein (1-42) is a bioactive peptide discovered by peptide screening. |
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V79434 | FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) | FITC-β-Ala-Amyloid β-Protein (1-42) ammonium is a FITC-labeled Aβ1-42 monomeric peptide. | |
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V79435 | FITC-β-Ala-β-Amyloid (25-35) | FITC-β-Ala-β-Amyloid (25-35) is a fluorescent product labeled by FITC and may be utilized in the research of AD/Alzheimer's disease. | |
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V79436 | FITC-β-Amyloid (25-35) | FITC-β-Amyloid (25-35) is FITC labeled β-Amyloid (25-35). | |
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V71357 | Fmoc-Ala-Glu-Asn-Lys-NH2 | 220701-06-4 | Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase AEP inhibitory peptide that can inhibit the cleavage of amyloid precursor protein APP. |
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