As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71422 | β-Amyloid (40-1) | 144409-99-4 | β-Amyloid (40-1) is a biologically active peptide. |
|
V71364 | β-Amyloid peptide(16-20) (KLVFF) | 153247-40-6 | β-Amyloid peptide(16-20) is an amino acid (AA) sequence (KLVFF) of Amyloid-β (Abeta). |
|
V71429 | β-Amyloid precursor protein (96-110), cyclized (human) | 289634-54-4 | β-Amyloid precursor protein (96-110), cyclized (human) is an amyloid precursor protein. |
|
V81810 | β-Amyloid-15N (1-40) (TFA) (Amyloid Beta-Peptide-15N (1-40) (human) TFA; Amyloid β-Peptide-15N (1-40) (human) TFA) | β-Amyloid-15N (1-40) (TFA) is 15N (Nitrogen 15)-labelled β-Amyloid (1-40) (TFA). | |
|
V81811 | β-Amyloid-15N (1-42), human TFA (Amyloid β-peptide-15N (1-42) (human) TFA) | β-Amyloid-15N (1-42), human (TFA) is 15N (Nitrogen 15)-labelled β-Amyloid (1-42) (TFA). | |
|
V85745 | β-Amyloid/A4 Protein Precusor (319-335) (APP (319-335)) | 148914-01-6 | |
![β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21))](http://www.invivochem.com/upload/1124/V71366.png)
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V71366 | β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21)) | 182912-74-9 | Beta-Sheet Breaker Peptide iAβ5 is a potent brain amyloid-beta (Abeta) degrader. |
|
V71407 | γ-Secretase modulator 13 | 1353570-40-7 | γ-Secretase modulator 13 (compound 4) is a γ-secretase modulator (GSMs) that can inhibit the production of aggregated amyloid β peptide Aβ42 with IC50 of 163 nM, may be utilized in AD/Alzheimer's disease study. |
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