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Beta Amyloid

Beta Amyloid

As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.

Beta Amyloid related products

Structure Cat No. Product Name CAS No. Product Description
2,3-Dehydrosilybin A V71438 2,3-Dehydrosilybin A 25166-14-7 2,3-Dehydrosilybin A is a longevity-promoting and anti-aggregation compound.
2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 V71371 2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 1331662-16-8 2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 is deuterated labeled 2-Hydroxy-5-(phenyldiazenyl)benzoic acid.
5-FAM-β-Amyloid (1-42), human TFA (5-FAM-Amyloid β-peptide (1-42) (human) TFA) V77650 5-FAM-β-Amyloid (1-42), human TFA (5-FAM-Amyloid β-peptide (1-42) (human) TFA) 5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) TFA is a 5-FAM-labeled β-Amyloid (1-42), human (TFA).
5-FAM-β-Amyloid (1-42), human Tris (5-FAM-Amyloid β-peptide (1-42) (human) Tris) V86199 5-FAM-β-Amyloid (1-42), human Tris (5-FAM-Amyloid β-peptide (1-42) (human) Tris)
6′-Methyl paeonol V83543 6′-Methyl paeonol 6540-66-5
7-Deoxy-trans-dihydronarciclasine V71443 7-Deoxy-trans-dihydronarciclasine 145987-74-2 7-Deoxy-trans-dihydronarciclasine is an alkaloid and an inhibitor (blocker/antagonist) of tobacco mosaic virus (TMV) (IC50= 1.80 μM).
[Ala28]-β Amyloid(25-35) (β(25-35)KA) V71439 [Ala28]-β Amyloid(25-35) (β(25-35)KA) 173993-86-7 [Ala28]-β Amyloid(25-35) (β(25-35)KA) is an electroneutral mutant peptide of Aβ(25-35) that accelerates the aggregation of firefly luciferase.
[Arg6]-β-Amyloid (1-40), england mutation V71378 [Arg6]-β-Amyloid (1-40), england mutation 1802084-26-9 [Arg6]-β-Amyloid (1-40), england mutation is a biologically active peptide.
[Arg6]-β-Amyloid (1-42), england mutation V77472 [Arg6]-β-Amyloid (1-42), england mutation [Arg6]-β-Amyloid (1-42), england mutation is a biologically active peptide.
[Asn23] β-Amyloid (1-40), Iowa mutation V71392 [Asn23] β-Amyloid (1-40), Iowa mutation 374796-72-2 [Asn23] β-Amyloid (1-40), Iowa mutation is a biologically active peptide.
[Asn23]-beta-Amyloid (1-42), iowa mutation V77473 [Asn23]-beta-Amyloid (1-42), iowa mutation [Asn23]-beta-Amyloid (1-42), iowa mutation is a biologically active peptide.
[D-Ser14]-Humanin V92286 [D-Ser14]-Humanin 570382-85-3 [D-Ser14]-Humanin is a biologically active peptide in which the Ser14 residue of humanin is changed from L-form to D-form.
AC 253 V71399 AC 253 151804-79-4 AC 253 is an antagonist of amylin, inhibiting 125I-adrenomedullin binding, with IC50 of 25 nM.
Acetly-β Amyloid(15-20), Amide V71397 Acetly-β Amyloid(15-20), Amide 189064-06-0 Acetly-β Amyloid (15-20), Amide is a polypeptide fragment.
Acetyl-Amyloid β-Protein (1-6) amide V71434 Acetyl-Amyloid β-Protein (1-6) amide 903883-22-7 Acetyl-Amyloid β-Protein (1-6) amide is a hexapeptide that contains potential copper(II) binding sites.
Acetyl-Tau Peptide (273-284)amide V71431 Acetyl-Tau Peptide (273-284)amide 1684399-52-7 Acetyl-Tau Peptide (273-284) amide is an acetylated Tau peptide fragment.
AChE-IN-59 V87778 AChE-IN-59 2957916-86-6 AChE-IN-59 (compounds 3b) is an inhibitor of AChE with an IC50 value of 0.05 µM.
AChE-IN-63 V87780 AChE-IN-63 876685-78-8 AChE-IN-63 is an inhibitor of hAChE, hBChE, and hBACE-1 (IC50=0.103 μM (hAChE), 10 μM (hBChE), and 1.342 μM (hBACE-1)).
AChE/Aβ-IN-1 V79836 AChE/Aβ-IN-1 AChE/Aβ-IN-1 (compound 32) is a potent oral acetylcholinesterase (AChE) inhibitor (antagonist) with IC50 of 86 nM and an NMDA receptor (GluN1-1b/GluN2B subunit combination) antagonist.
AChE/Aβ-IN-2 V79835 AChE/Aβ-IN-2 AChE/Aβ-IN-2 (compound 32) is a potent oral acetylcholinesterase (AChE) inhibitor (antagonist) with IC50 of 86 nM and an NMDA receptor (GluN1-1b/GluN2B subunit combination) antagonist.
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