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ChE

ChE

The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.

ChE related products

Structure Cat No. Product Name CAS No. Product Description
AChE-IN-36 V77756 AChE-IN-36 AChE-IN-36 is an acetylcholinesterase inhibitor (antagonist) with IC50 of 0.04 μM.
AChE-IN-37 V79737 AChE-IN-37 AChE-IN-37 is an acetylcholinesterase inhibitor (antagonist) with IC50 of 0.23 μM.
AChE-IN-39 V80075 AChE-IN-39 AChE-IN-39 (Compound 7c) is an AChE inhibitor (IC50= 0.058 μM).
AChE-IN-4 V77758 AChE-IN-4 AChE-IN-4 is an acetylcholinesterase inhibitor (AChEI) with IC50 of 24.1μM.
AChE-IN-40 V79242 AChE-IN-40 AChE-IN-40 (Compound 5C) is an AChE inhibitor (IC50= 120 nM).
AChE-IN-42 V77759 AChE-IN-42 AChE-IN-42 (Compound 28) is an AChE inhibitor (Ki= 0.44?μM).
AChE-IN-43 V77902 AChE-IN-43 AChE-IN-43 is a potent selective inhibitor of AChE with a Ki of 0.41 μM.
AChE-IN-44 V71700 AChE-IN-44 2758685-58-2 AChE-IN-44 (Compound Tap4) is an AChE inhibitor.
AChE-IN-45 V77760 AChE-IN-45 AChE-IN-45 (Compound 14) is an acetylcholinesterase (AChE) inhibitor (antagonist) with IC50 of 11.57±0.45 nM and has antioxidant and neuro-protective (neuro-protection) activities.
AChE-IN-46 V80337 AChE-IN-46 AChE-IN-46 (compound 4) is a β-cyclocostunolide, an AChE inhibitor.
AChE-IN-47 V85575 AChE-IN-47 3033056-55-9
AChE-IN-48 V85899 AChE-IN-48
AChE-IN-49 V85334 AChE-IN-49
AChE-IN-51 V84304 AChE-IN-51
AChE-IN-52 V85718 AChE-IN-52 2214210-63-4
AChE-IN-54 V84763 AChE-IN-54
AChE-IN-55 V84684 AChE-IN-55
AChE-IN-56 V83695 AChE-IN-56
AChE-IN-57 V83433 AChE-IN-57
AChE-IN-8 V71693 AChE-IN-8 2919335-82-1 AChE-IN-8 (Compound 19) is a potent AChE inhibitor (antagonist) with IC50 of 1.95 μM.
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