The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V85172 | AChE/Aβ-IN-3 | ||
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V85087 | AChE/Aβ-IN-4 | ||
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V71684 | AChE/BChE-IN-1 | 2720624-42-8 | AChE/BChE-IN-1 is a potent and BBB (blood-brain barrier) permeable (penetrable) dual (bifunctional) inhibitor of acetylcholinesterase (Acetylcholinesterase) and butyrylcholinesterase (Butyrylcholinesterase), with IC50s of 1.06 for hAChE and hBChE respectively. |
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V71698 | AChE/BChE-IN-10 | 2924824-48-4 | AChE/BChE-IN-10 (Compound 7b) is a potent dual (bifunctional) inhibitor of AChE and BChE with IC50s of 0.176 and 0.47 μM, respectively. |
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V71685 | AChE/BChE-IN-11 | 80443-12-5 | AChE/BChE-IN-11 (compound 1) is a potent dual (bifunctional) inhibitor of AChE and BChE with IC50s of 70 and 71 μM for AChE and BChE, respectively. |
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V77748 | AChE/BChE-IN-13 | AChE/BChE-IN-13 (compound 5j) is a potent dual (bifunctional) inhibitor of AChE and BChE with IC50s of 20.89 and 17.37 μM, respectively. | |
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V80010 | AChE/BChE-IN-14 | AChE/BChE-IN-14 (compound 13) is a phenylisoquinoline alkaloid extracted from Polycauliflower roots. | |
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V78473 | AChE/BChE-IN-15 | AChE/BChE-IN-15 (Compound 6d) is an AChE/BChE inhibitor (antagonist) with IC50 of 20 nM and 220 nM, respectively. | |
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V85344 | AChE/BChE-IN-16 | ||
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V71689 | AChE/BChE-IN-3 hydrochloride | 2410992-69-5 | AChE/BChE-IN-3 (BMC-1) HCl is a dual (bifunctional) inhibitor of AChE and BChE with IC50s of 6.08 μM and 0.383 μM for electric eel AChE (elAChE) and horse serum BChE (eqBChE), respectively. |
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V78881 | AChE/BChE/MAO-B-IN-2 | AChE/BChE/MAO-B-IN-2 is a potent inhibitor of AChE, BChE and MAO-B enzymes with IC50s of 48.2 nM, 83.9 nM and 31.2 nM respectively. | |
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V78882 | AChE/BChE/MAO-B-IN-3 | AChE/BChE/MAO-B-IN-3 is a 1-indanone analogue and a potent MAO-B inhibitor (antagonist) with IC50 of 0.0359 μM for human MAO-B. | |
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V78730 | AChE/BChE/MAO-B-IN-4 | AChE/BChE/MAO-B-IN-4 is a 1-indanone analogue and a potent MAO-B inhibitor (antagonist) with IC50 of 0.0359 μM for human MAO-B. | |
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V71628 | AChE/BuChE-IN-4 | 1997158-25-4 | AChE/BuChE-IN-4 (compound 4a) is a multi-target AChE/BuChE inhibitor (antagonist) with oral activity and BBB (blood-brain barrier) permeability. |
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V70698 | AChE/BuChE/MAO-B-IN-1 | 2834758-29-9 | AChE/BuChE/MAO-B-IN-1 is an inhibitor (blocker/antagonist) of human acetylcholinesterase (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B), with IC50 of 4.8 μM and 13.7 μM respectively. |
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V79947 | AChE/BuChE/MAO-B-IN-2 | AChE/BuChE/MAO-B-IN-2 (compound 4b) is a drug with AChE/BuChE inhibitory effect. | |
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V79154 | AChE/MAO-B-IN-4 | AChE/MAO-B-IN-4 (compound 4a) is a selective dual (bifunctional) inhibitor of AChE and MAO-B. | |
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V79015 | AChE/MAO-B-IN-5 | AChE/MAO-B-IN-5 is a dual (bifunctional) inhibitor of AChE and MAO-B. | |
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V77751 | AChE/MAO-B-IN-6 | AChE/MAO-B-IN-6 (compound 3a) is a dual (bifunctional) inhibitor of AChE and h-MAO-B and may be used to inhibit Alzheimer's disease (AD). | |
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V79288 | AChE/MAO-IN-2 | Dual AChE-MAO B-IN-5 is an indanone analogue and a potent dual AChE/MAO-B inhibitor (antagonist) with IC50s of 0.0224 and 0.0412 for AChE, MAO-B and MAO-A respectively. |
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