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ChE

ChE

The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.

ChE related products

Structure Cat No. Product Name CAS No. Product Description
AChE/Nrf2 modulator 1 V71671 AChE/Nrf2 modulator 1 2417117-84-9 AChE/Nrf2 modulator 1 is an orally bioactive acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator.
Aldicarb sulfone-13C2,d3 (aldicarb sulfone 13C2,d3) V71666 Aldicarb sulfone-13C2,d3 (aldicarb sulfone 13C2,d3) 1261170-76-6 Aldicarb sulfone-13C2,d3 is the 13C (carbon 13)-labeled deuterated form of Aldicarb sulfone.
Aloveroside A V71662 Aloveroside A 1246930-65-3 Aloveroside A is a triglucosylnaphthalene analogue extracted from ethanolic extract of aloe vera.
Anatoxin-a (ATX-a) V85711 Anatoxin-a (ATX-a) 64285-06-9
Artanin V71687 Artanin 96917-26-9 Artanin is a coumarin with bioactivity associated with AD/Alzheimer's disease.
Axillaridine A V71674 Axillaridine A 128255-16-3 Axillaridine A can be extracted from Sarcococcus hougli var.
BChE-IN-15 V79320 BChE-IN-15 BChE-IN-15 (Compound 6) is a pseudo-irreversible, covalent BChE inhibitor (antagonist) with IC50 of 1.76 nM for hBChE.
BChE-IN-16 V78353 BChE-IN-16 BChE-IN-16 (compound 87) is a potent BChE inhibitor (antagonist) with IC50 of 3.8 nM for hBChE.
BChE-IN-17 V71704 BChE-IN-17 2425632-57-9 BChE-IN-17 (compound 6n) is a potent and specific BChE inhibitor (antagonist) with IC50s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively.
BChE-IN-19 V78828 BChE-IN-19 BChE-IN-19 (Compound 7b) is a para-substituted analogue of indanone with inhibitory effect against butyrylcholinesterase (BChE) (IC50=0.04 μM).
BChE-IN-2 V79380 BChE-IN-2 BChE-IN-2 (compound 22) is a potent BChE inhibitor (antagonist) with Ki of 0.099 μM.
BChE-IN-20 V71629 BChE-IN-20 1428439-79-5 BChE-IN-20 (compound 7c) is a potent and specific inhibitor of BChE with IC50s of 105 nM and 2.3 nM for eqBChE and hBChE, respectively.
BChE-IN-21 V78354 BChE-IN-21 BChE-IN-21 is a potent BChE inhibitor (antagonist) with IC50 of 0.14±0.02 μM.
BChE-IN-22 V84263 BChE-IN-22
BChE-IN-23 V84949 BChE-IN-23 2020357-32-6
BChE-IN-24 V84493 BChE-IN-24
BChE-IN-25 V84867 BChE-IN-25 79183-25-8
BChE-IN-26 V84937 BChE-IN-26
Bis(7)-tacrine dihydrochloride V70437 Bis(7)-tacrine dihydrochloride 224445-12-9 Bis(7)-tacrine di-HCl is a dimeric acetylcholinesterase (AChE) inhibitor found in tacrine.
Bis-(-)-8-demethylmaritidine V78055 Bis-(-)-8-demethylmaritidine Bis-(-)-8-demethylmaritidine is a naturally occurring alkaloid and a potent acetylcholinesterase (AChE) inhibitor.
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