The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81055 | PD07 | PD07 is an orally bioactive AChE inhibitor (IC50= 0.29 μM for hAChE). | |
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V81057 | PD10 | PD10 is an AChE and BuChE inhibitor (hAChE IC50= 0.56 μM; eeAChE IC50= 0.59 μM; eqBuChE IC50= 1.06 μM). | |
|
V79094 | PD24 | PD24 is an AChE and BuChE inhibitor (hAChE IC50= 1.72 μM; eeAChE IC50= 1.76 μM; eqBuChE IC50= 2.64 μM). | |
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V79004 | PD25 | PD25 is an AChE and BuChE inhibitor (hAChE IC50= 1.58 μM; eeAChE IC50= 1.63 μM; eqBuChE IC50= 2.39 μM). | |
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V71676 | Picfeltarraegenin | 1391826-61-1 | Picfeltarraenin X is a triterpenoid and an AChE inhibitor. |
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V71670 | Piperilate (Pipethanate) | 4546-39-8 | Piperilate (Pipethanate) is a mixture of zazepine analogues, PAF antagonists and anticholinergic active molecules, and may be utilized in bronchial asthma research. |
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V25970 | Pralidoxime Chloride (2-PAM chloride) | 51-15-0 | Pralidoxime Chloride (2-PAM chloride) is a useful anti-dote agent for organophosphate poisoning. |
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V71619 | Profenofos | 41198-08-7 | Profenofos is a pesticide extensively used on farm crops, vegetables and fruit crops. |
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V71636 | Protopine hydrochloride (Corydinine hydrochloride) | 6164-47-2 | Protopine HCl is an isoquinoline alkaloid and a specific, reversible and competitive inhibitor of acetylcholinesterase. |
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V71661 | Protriptyline (N-methyl-d3) (hydrochloride) | 1435934-21-6 | Protriptyline (N-methyl-d3) ( HCl) is the deuterated form of Protriptyline HCl. |
|
V51721 | Pseudocoptisine chloride (Isocoptisine chloride) | 30044-78-1 | Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with a benzylisoquinoline skeleton. |
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V84638 | Pumiloside | 126722-26-7 | |
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V81258 | Pyridostigmine-d3 bromide (pyridostigmine d3 bromide (bromide)) | Pyridostigmine-d3 (bromide) is the deuterated form of Pyridostigmine bromide. | |
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V71621 | Pyridostigmine-d6 bromide (pyridostigmine d6 bromide (bromide)) | 2375858-08-3 | Pyridostigmine-d6 (bromide) is the deuterium labelled form of Pyridostigmine. |
|
V33475 | Rivastigmine | 123441-03-2 | Rivastigmine, also known as ENA-713 and SDZ-ENA 713, is a reversible cholinesterase inhibitor with IC50 of 5.5 μM,it isused as a parasympathomimetic or cholinergic agent for the management of mild to moderate Alzheimer disease, Dementia, and Parkinson's Disease. |
|
V71639 | Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) | 1346242-31-6 | Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity in Rivastigmine. |
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V84705 | Salvianolic acid H | 444179-57-1 | |
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V71705 | SB-1436 | 2925298-08-2 | SB-1436 is a cholinesterase (ChE) inhibitor that can suppress acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE). |
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V28743 | Scopoletin (Gelseminic acid; Chrysatropic acid) | 92-61-5 | Scopoletin is an acetylcholinesterase (AChE) inhibitor. |
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V71695 | SD-6 | 744206-31-3 | SD-6 is an orally bioactive hAChE and hBChE inhibitor (antagonist) with IC50s of 0.907 µM and 1.579 µM, respectively. |
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