ChE

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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ChE

The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.

ChE related products

Cat No.	Product Name	CAS No.	Product Description
V79221	Dual AChE-MAO B-IN-1		Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable, CNS-penetrating, potent inhibitor of human AChE (IC50=550 nM) and MAO-B (IC50=8.2 nM) .
V79222	Dual AChE-MAO B-IN-3		Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitor (antagonist) with IC50s of 0.58 and 0.41 μM, respectively.
V101896	Dual AChE-MAO B-IN-4		Dual AChE-MAO B-IN-4 (Compound 7) is a dual AChE/MAO-B inhibitor with IC50 values of 261 nM and 15 nM, respectively.
V71688	Ebeiedinone (dehydrobeidine base)	25650-68-4	Ebeiedinone is a Fritillary steroid alkaloid that can inhibit the bioactivity of human whole blood cholinesterase (ChE) at a concentration of 0.1 mM with an inhibition rate of 69.0%.
V71646	Echimidine N-oxide	41093-89-4	Echimidine N-oxide is a pyrrolizidine alkaloid with acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
V79244	Edrophonium-d5 chloride (Edrophonium d5 (chloride))		Edrophonium-d5 (chloride) is the deuterated form of Edrophonium chloride.
V71699	eeAChE-IN-1	2763366-27-2	eeAChE-IN-1 is a strong eeAChE inhibitor (antagonist) with IC50 of 23 nM.
V71696	eeAChE-IN-2	2763366-33-0	eeAChE-IN-2 is a strong eeAChE inhibitor (antagonist) with IC50 of 2 nM.
V87799	eeAChE-IN-3		eeAChE-IN-3 (compound YS3g) is an orally active, potent EeAChE and IL-6 inhibitor with IC50 of 0.54 μM, 0.49 μM, 8.54 μM and 0.57 μM for EeAChE, RatAChE, RatBuChE and IL-6, respectively.
V85398	eeAChE/eqBuChE-IN-1	2921654-26-2
V79389	Fasciculin-I (FAS-I)		Fasciculin-I was extracted from mambas venom.
V71672	Fasciculin-II (Fas-2)	95506-56-2	Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE).
V71642	Feralolide	149418-38-2	Feralolide is a dihydroisocoumarin extracted from the methanolic extract of aloe vera resin.
V71673	Fosthiazate (fosthiazate)	98886-44-3	Fosthiazate is a broad-spectrum nematicide that can inhibit the synthesis of acetylcholinesterase in a variety of plant-parasitic nematodes such as Meloidogyne spp.
V102805	Graphislactone A	52179-44-9	Graphislactone A is an antioxidant found in Cephalosporium IFB-E001 and M. olivacea.
V94264	GSK1034702 hydrochloride	932373-86-9	GSK1034702 hydrochloride is an allosteric agonist of M1 mAChR.
V79489	hAChE-IN-1		hAChE-IN-1 (Compound 24) is a potent inhibitor of hAChE with IC50 of 1.09 μM.
V105156	hAChE-IN-10	3058182-98-9	hAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with IC50 of 6.34 nM.
V79517	hAChE-IN-2		hAChE-IN-2 is a potent hAChE inhibitor (antagonist) with IC50 of 0.71 μM.
V79692	hAChE-IN-4	2983723-58-4	hAChE-IN-4 (Compd 5d) is a potent, BBB (blood-brain barrier)-passing hAChE inhibitor (antagonist) with IC50 of 0.25 μM.