Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71809 | Alogabat (RG-7816; RO-7017773) | 2230009-48-8 | Alogabat (example 8) is a positive isomeric modulator (PAM) of the GABAA α5 receptor (information from patent WO2018104419A1). |
|
V7371 | Amentoflavone | 1617-53-4 | Amentoflavone (Didemethyl-ginkgetin) is a potent and orally bioactive negative modulator of GABA(A). |
|
V71824 | Anisatin (shikitoxin) | 5230-87-5 | Anisatin is a toxic substance extracted from the seeds of a Japanese plant Illicium anisatum. |
|
V60126 | Arecaidine | 499-04-7 | Arecoline, a pyridine alkaloid, is a potent corrector of GABA absorption. |
|
V71827 | Arecaidine hydrobromide | 6013-57-6 | Arecaidine HBr, a pyridine alkaloid, is a potent GABA absorption inhibitor. |
|
V60121 | Arecaidine hydrochloride | 6018-28-6 | Arecoline HCl, a pyridine alkaloid, is a potent GABA uptake kinase. |
|
V2113 | AZD7325 | 942437-37-8 | AZD-7325 is a novel, potent and selectiveGABAA(α2/3) receptormodulator, used for treatment of generalized anxiety disorder. |
|
V7739 | Baclofen | 1134-47-0 | Baclofen (also known as STX 209) is a derivative of gamma-aminobutyric acid and aselectiveGABAB receptoragonist. |
|
V71820 | Baclofen-d4 (Baclofen d4) | 1189938-30-4 | Baclofen-d4 is the deuterium labelled form of Baclofen. |
|
V71833 | Bodipy TMR-X muscimol | 849464-08-0 | Bodipy TMR-X muscimol is a Bodipy labeled muscimol (Ex=543 nm, Em=572 nm). |
|
V71851 | CGP36216 | 123691-29-2 | CGP36216 (Compound 9) is a GABAB receptor antagonist. |
|
V70278 | Chrodrimanin B | 132196-54-4 | Chrodrimanin B is a fungal metabolite and a potent, non-open B. |
|
V71816 | CI-966 hydrochloride | 110283-66-4 | CI-966 HCl is a specific, orally bioactive and BBB (blood-brain barrier) permeable (penetrable) inhibitor of the GABA transporter GAT-1. |
|
V71813 | COR659 | 544450-68-2 | COR659 is a potent PAM (positive allosteric modulator) of GABAB. |
|
V70267 | Difludiazepam (Ro 07-4065) | 39080-67-6 | Difludiazepam (Ro 07-4065) is a benzodiazepine with a binding affinity for GABAA receptors of 0.613. |
|
V84104 | Diproqualone ((±)-Diproqualone) | 36518-02-2 | |
|
V60124 | DL-Menthol | 89-78-1 | DL-Menthol is the relative configuration of (-)-Menthol. |
|
V70291 | Doxefazepam (SAS-643) | 40762-15-0 | Doxefazepam is a benzodiazepine analogue with anxiolytic (anti-anxiety) and anticonvulsant (antiepileptic/antiseizure) effects. |
|
V71831 | DPNI-GABA | 927866-58-8 | DPNI-GABA is a nitroindoline cage compound that can inhibit GABA(A) receptors and reduces GABA-induced peak responses with IC50 of 0.5 mM. |
|
V71830 | E2730 | 1520073-91-9 | E2730 is a noncompetitive but selective inhibitor of gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with orally bioavailable and antiepileptic activity. |
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