Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71832 | Isonipecotic acid-d9 (4-piperidinecarboxylic acid-d9) | 1219798-43-2 | Isonipecotic acid-d9 is the deuterium labelled form of Isonipecotic acid. |
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V31861 | LAU159 | 2055050-87-6 | LAU159 is a functionally selective positive modulator of the α1β3 GABA(A) receptor with EC50 of 2.2 μM. |
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V71801 | Lesogaberan hydrochloride (AZD-3355 hydrochloride) | 2925644-17-1 | Lesogaberan (AZD-3355) HCl is a potent and specific GABAB receptor agonist/activator with EC50 of 8.6 nM for human recombinant GABAB receptor. |
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V70285 | Lesogaberan napadisylate (AZD-3355 napadisylate) | 477956-38-0 | Lesogaberan (AZD-3355) napadisylate is a potent and specific GABAB receptor agonist/activator with EC50 of 8.6 nM for human recombinant GABAB receptor. |
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V10946 | Loreclezole | 117857-45-1 | Loreclezole (R-72063; R 72063; R72063), a triazole analog, is a sedative, anti-seizure/anticonvulsant and antiepileptic agent thatacts as a positive allosteric modulator (PAM) ofGABAAreceptor. |
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V24395 | Lorediplon | 917393-39-6 | Lorediplon, a nonbenzodiazepine of the pyrazolopyrimidine family, is a non-benzodiazepine drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep. |
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V24414 | Lotilaner | 1369852-71-0 | Lotilaner (Credelio) is a potent insecticide agent (veterinary drug)acting as a non-competitive antagonist of insect GABA receptors. |
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V70279 | MIDD0301 (GL-II-93) | 2187489-08-1 | MIDD0301 (GL-II-93) is an orally bioactive, anti-asthmatic PAM (positive allosteric modulator) of GABAA receptors. |
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V80795 | MmTx1 toxin (Microrotoxin 1) | MmTx1 toxin (Micrurotoxin 1) is an allosteric GABAA receptor modulator that increases GABAA receptor sensitivity to agonists. | |
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V80796 | MmTx2 toxin (Microrotoxin 2) | MmTx2 toxin is a GABAA receptor modulator that enhances the sensitivity of GABAA receptors to agonists. | |
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V71802 | MRK-016 | 342652-67-9 | MRK-016 is a selective, orally bioavailable, BBB (blood-brain barrier) permeable (penetrable) GABAA α5 receptor antagonist (inhibitor) with EC50 of 3 nM for GABAA α5 and human GABAA α1β3γ2, GABAA α2β3γ2, GABAA α3β3γ2 and GABAA α5β3γ2 The Kis were 0.83, 0.85, 0.77 and 1.4 nM respectively. |
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V71798 | MRK-898 | 461450-30-6 | MRK-898 is an orally bioavailable GABA(A) receptor modulator. |
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V71805 | Muscimol hydrochloride (Agarin hydrochloride; Agarine hydrochloride) | 3579-03-1 | Muscimol (Agarin; Agarine) HCl is a psychoactive isoxazole. |
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V70273 | N-Arachidonyl-GABA | 128201-89-8 | N-Arachidonyl-GABA is a fatty amino acid (AA) related to anandamide found in bovine brain. |
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V71828 | NCS-382 | 520505-01-5 | NCS-382 is a potent GABA receptor antagonist and a GHBR receptor antagonist. |
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V70280 | NCS-382 sodium | 131733-92-1 | NCS-382 (sodium) is a potent GABA receptor antagonist. |
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V71807 | Nipecotic acid (3-Piperidine; (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine) | 498-95-3 | Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial aminobutyric acid (GABA) uptake in vitro. |
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V71835 | NNC 05-2090 | 184845-43-0 | NNC 05-2090 is a potent mGAT2 inhibitor (antagonist) with Ki of 1.4 μM. |
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V71834 | NNC05-2090 hydrochloride | 184845-18-9 | NNC05-2090 HCl is a GABA uptake inhibitor. |
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V12242 | Norepinephrine bitartrate | 51-40-1 | Norepinephrine bitartrate(Levarterenol; L-Noradrenaline) is a potent and β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. |
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