Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70271 | Withasomniferolide B | 2365386-75-8 | Withasomniferolide B is a withanolide. |
|
V71838 | Xilmenolone | 2368807-26-3 | Xilmenolone is a GABAA receptor positive allosteric modulator (PAM). |
|
V71852 | Zopiclone N-oxide (RP 29753) | 43200-96-0 | Zopiclone N-oxide (RP 29753) is the less bioactive metabolite of Zopiclone. |
|
V70283 | γ-Acetylenic GABA (GAG) | 57659-38-8 | γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible GABA-aminase inhibitor. |
|
V71848 | γ-Acetylenic GABA hydrochloride (GAG hydrochloride) | 103451-26-9 | γ-Acetylenic GABA (GAG) HCl is an irreversible GABA-aminase inhibitor. |
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