Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71815 | (E)-GABAB receptor antagonist 1 | 1611483-29-4 | (E)-GABAB receptor antagonist 1 is the trans structure of GABAB receptor antagonist 1. |
|
V70286 | (S)-Cipepofol ((S)-Ciprofol; (S)-HSK3486) | 1637741-59-3 | (S)-Cipepofol is the inactive isomer of Cipepofol. |
|
V70288 | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) | 4641-57-0 | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a GABA analog that has sedative effects and can reduce exploratory behavior in rats at 50-100 mg/kg (intravenous injection). |
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V71853 | 12,14-Dichlorodehydroabietic acid | 65281-77-8 | 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. |
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V71812 | 17β-Estradiol sulfate sodium (17β-Estradiol 3-sulfate sodium) | 4999-79-5 | 17β-Estradiol sulfate (sodium), known also as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid. |
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V71182 | 2'-O-Methylisoliquiritigenin | 51828-10-5 | 2'-O-Methylisoliquiritigenin can be extracted from Arachis and can upregulate the 5-HT, NE, DA and GABA signaling pathways, but has little effect on the NE pathway. |
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V71844 | 2'MeO6MF | 89112-85-6 | 2'MeO6MF is a BBB (blood-brain barrier) permeable (penetrable) PAM (positive allosteric modulator) of α2β1γ2L and all α1-containing GABAA receptors. |
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V71840 | 3-Aminopropylphosphinic acid (3-APPA; CGP 27492; CGA 147823) | 103680-47-3 | 3-Aminopropylphosphinic acid (3-APPA) is a phosphate analog of GABA and a potent and specific GABAB receptor agonist (activator). |
|
V85020 | 3-Aminopropylphosphonic acid ((3-Aminopropyl)phosphonic acid) | 13138-33-5 | |
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V85426 | 3-Ethyl-3-methylthiolan-2-one | 103620-92-4 | |
|
V71817 | 3-Methyl-GABA | 1216629-00-3 | 3-Methyl-GABA is a potent GABA aminotransferase activator. |
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V71811 | 3-Methylglutaconic acid (β-Methylglutaconic acid) | 5746-90-7 | 3-Methylglutaconic acid is the major metabolite accumulated in 3-methylglutaric aciduria (MGTA). |
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V51181 | Etiocholanolone (5β-Androsterone) | 53-42-9 | Etiocholanolone (5β-Androsterone) is a testosterone excretion aid with anticonvulsant (antiepileptic/antiseizure) activity. |
|
V70289 | 6-Aminonicotinic acid | 3167-49-5 | 6-Aminonicotinic acid is a GABAA receptor agonist (activator) with Ki of 4.4 nM. |
|
V71826 | AA29504 | 945828-50-2 | A29504 is an ethyl carbamate with gamma-aminobutyric acid (GABAA) receptor activity. |
|
V71822 | Acamprosate-d3 calcium | 1225580-94-8 | Acamprosate-d3 (calcium) is the deuterated form of Acamprosate calcium. |
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V71821 | Acamprosate-d6 calcium | 1225580-91-5 | Acamprosate-d6 (calcium) is deuterium labelled Acamprosate calcium. |
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V71799 | Afizagabar (S44819; Egis-13529) | 1398496-82-6 | Afizagabar (S44819) is a first-in-class, competitive, and selective α5-GABAAR antagonist (inhibitor) with IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. |
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V71809 | Alogabat (RG-7816; RO-7017773) | 2230009-48-8 | Alogabat (example 8) is a positive isomeric modulator (PAM) of the GABAA α5 receptor (information from patent WO2018104419A1). |
|
V71824 | Anisatin (shikitoxin) | 5230-87-5 | Anisatin is a toxic substance extracted from the seeds of a Japanese plant Illicium anisatum. |
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