A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80144 | Lysyl hydroxylase 2-IN-1 | Lysyl hydroxylase 2-IN-1 (compound 12) is a selective lysyl hydroxylase 2 (LH2) inhibitor (antagonist) with IC50 of approximately 300 nM. | |
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V80029 | Lysyl hydroxylase 2-IN-2 | Lysyl hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl hydroxylase 2 (LH2) with IC50 of approximately 500 nM. | |
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V2308 | Lysyl oxidase inhbitor 1 | 2409963-83-1 | Lysyl oxidase inhbitor 1 is a novel and potent inhibitor of lysyl oxidase, whose upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous. |
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V86089 | MAO-A inhibitor 1 | 119229-96-8 | |
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V83416 | MAO-A inhibitor 2 | ||
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V70688 | MAO-A/5-HT2AR-IN-1 | 2769156-00-3 | MAO-A/5-HT2AR-IN-1 (compound I14) is a potent dual (bifunctional) inhibitor of MAO-A and 5-HT2AR with IC 50 of 0.004 and 0.014 μM, respectively. |
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V80133 | MAO-A/B-IN-2 | MAO-A/B-IN-2 (Compound 30) is an MAO-A/B inhibitor (antagonist) with IC50s of 17.8 and 15.8 μM for MAO-A and MAO-B, respectively. | |
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V70682 | MAO-B-IN-10 | 2376710-36-8 | MAO-B-IN-10 (compound 4f) is a specific, BBB (blood-brain barrier) penetrating MAO-B (monoamine oxidase-B) inhibitor (antagonist) with IC50 of 5.3 μM. |
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V70689 | MAO-B-IN-17 | 2890188-81-3 | MAO-B-IN-17 is a selective monoamine oxidase B (MAO-B) inhibitor (antagonist) with IC50 of 5.08 μM and may be utilized in the study of PD/Parkinson's disease. |
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V79013 | MAO-B-IN-18 | MAO-B-IN-18 is a potent and specific MAO B inhibitor (antagonist) with IC50 of 52 nM and 14 μM for hMAO B and hMAO A respectively. | |
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V70646 | MAO-B-IN-2 | 1253978-24-3 | MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50s of 0.51 and 7.00 μM, respectively. |
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V79879 | MAO-B-IN-20 | MAO-B-IN-20 (Compound C14) is a potent inhibitor of MAO-B with IC50 of 0.037 μM. | |
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V70699 | MAO-B-IN-21 | 2956426-18-7 | MAO-B-IN-21 is a potent MAO-B inhibitor (antagonist) with anti-oxidant effect and anti-Aβ aggregation activity. |
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V70663 | MAO-B-IN-23 | 2107978-22-1 | MAO-B-IN-23 (Compound 11f) is a reversible and competitive MAO-B inhibitor (IC50= 1.44 μM, Ki= 0.51 μM). |
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V80681 | MAO-B-IN-25 | MAO-B-IN-25 (compound 92) is a selective MAO-B inhibitor (antagonist) with IC50s of 0.5 nM and 240 nM for MAO-A and MAO-B, respectively. | |
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V70656 | MAO-B-IN-27 | 788824-83-9 | MAO-B-IN-27 (Compound 12c) is a monoamine oxidase B (MAO-B) inhibitor. |
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V86217 | MAO-B-IN-28 | 3028096-72-9 | |
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V84587 | MAO-B-IN-29 | 122823-57-8 | |
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V79144 | MAO-B-IN-3 | MAO-B-IN-3 is a reversible and selective MAO-B inhibitor (IC50=96 nM). | |
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V83442 | MAO-B-IN-30 | 82973-15-7 |
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