A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70645 | PXS-6302 | 2584947-54-4 | PXS-6302 is an irreversible lysine oxidase (LOX) inhibitor (antagonist) with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 respectively. |
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V70641 | PXS-6302 hydrochloride | 2584947-79-3 | PXS-6302 HCl is an irreversible lysine oxidase (LOX) inhibitor (antagonist) with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rhLOXL4). |
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V79458 | PZ-1922 | PZ-1922 (Compound 16) is a brain barrier-penetrating 5-HT6R/5-HT3R antagonist (Ki 17 nM and 0.45 nM, respectively). | |
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V2066 | RO-41-1049 hydrochloride | 127917-66-2 | Ro 41-1049 hydrochloride, the hydrochloride salt ofRo 41-1049, is a novel, potent, selective, reversible and orally bioavailable inhibitor of MAO-A (Monoamine oxidase). |
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V70651 | Rubrofusarin triglucoside | 245724-07-6 | Rubrofusarin triglucoside is a glycoside compound extracted from Cassia seeds and can inhibit human monoamine oxidase A (hMAO-A) with IC50 of 85.5 μM. |
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V70666 | Safrazine | 33419-68-0 | Safrazine is an irreversible, nonspecific MAO (monoamine oxidase) inhibitor (antagonist) with oral activity. |
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V70674 | Salsolidine hydrochloride ( Salsolidine hydrochloride; Salsolidine hydrochloride) | 63283-42-1 | Salsolidine HCl is a tetrahydroisoquinoline alkaloid that can stereoselectively and competitively inhibit the activity of MAO (monoamine oxidase) A (MAO A). |
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V70647 | SSAO inhibitor-1 | 2242883-04-9 | SSAO inhibitor-1 is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor. |
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V70667 | SWS1 | 2922115-32-8 | SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50= 1.8 nM) with anti-cancer activity. |
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V0089 | TB5 | 948841-07-4 | TB5 is a novel, potent, selective, reversible and competitive inhibitor of hMAO-B (human monoamine oxidase-B) with Kivalue of 0.11±0.01 μM. |
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V70659 | Tisolagiline (KDS2010) | 1894207-44-3 | Tisolagiline (KDS2010) is a reversible MAO-B inhibitor used in Parkinson's disease (PD) research. |
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V70680 | Tranylcypromine (SKF 385) | 155-09-9 | Tranylcypromine (SKF 385) is a potent MAO (monoamine oxidase) inhibitor. |
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V70681 | WAY-620147 | 515866-67-8 | WAY-620147 (compound 6) is an N-(2-morpholinoethyl)nicotinamide analogue that can inhibit monoamine oxidase (Monoamine Oxidase). |
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