A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70662 | (+)-Cinchonaminone | 60305-15-9 | (+)-Cinchonaminone displays MAO (monoamine oxidase) inhibitory activity. |
|
V87820 | (1S,2R)-Tranylcypromine-d5 hydrochloride | (1S,2R)-Tranylcypromine-d5 (hydrochloride) is the deuterated derivative of Tranylcypromine hydrochloride. | |
|
V87826 | (R)-Safinamide | 174756-44-6 | (R)-Safinamide is the enantiomer of safinamide and can inhibit MAO-B with an IC50 value of 0.45 μM. |
|
V70685 | (±)-Amiflamine (FLA 336) | 77502-96-6 | (±)-Amiflamine (FLA 336) is a potent MAO (monoamine oxidase) (MAO-A) with pIC50 of 5.57. |
|
V70672 | 1,4-Naphthoquinone-d6 | 26473-08-5 | 1,4-Naphthoquinone-d6 is the deuterated form of 1,4-Naphthoquinone. |
|
V70693 | 1-Methyl-2-undecyl-4(1H)-quinolone | 59443-02-6 | 1-Methyl-2-undecyl-4(1H)-quinolone is a potent irreversible and selective monoamine oxidase type B (MAO-B) inhibitor. |
|
V70643 | 4-Hydroxyderricin | 55912-03-3 | 4-Hydroxyderricin is one of the main active ingredients of Ashitaba and is a potent and specific MAO-B (monoamine oxidase inhibitor) inhibitor (antagonist) with IC50 of 3.43 μM. |
|
V101924 | 5-LOX-IN-7 | 1272519-89-7 | LOX-IN-7 (Compound 18) is a potent LOX inhibitor. |
|
V102297 | 6,7-Dimethylisatin | 20205-43-0 | 6,7-Dimethylindigo (compound 1l), an indigo analog, is also a potent MAO inhibitor with IC50 values of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively. |
|
V70678 | 6-Acetonyl-N-methyldihydrodecarine | 1253740-09-8 | 6-Acetonyl-N-methyldihydrodecarine is an alkaloid extracted from the roots of Zanthoxylum rigidum and is an inhibitor (blocker/antagonist) of MAO (monoamine oxidase). |
|
V90920 | Acacetin 7-O-(6-O-malonylglucoside) | 155049-92-6 | Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase (MAO) inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values of 2.34 and 1.87 μM, respectively. |
|
V70640 | Aminoacetone hydrochloride | 7737-17-9 | Aminoacetone HCl is the simplest single peptide. |
|
V78050 | Antioxidant agent-13 | 2966778-87-8 | Antioxidant agent-13 (Compound 5f) is an antioxidant. |
|
V87818 | Bazinaprine | 94011-82-2 | Bazinaprine (SR 95191) is a derivative of minaprine and an orally active monoamine oxidase type A (MAO) inhibitor. |
|
V85269 | ChEs/MAOs-IN-1 | ||
|
V70684 | Chrysophanol-1-O-β-gentiobioside (Chrysophanol-1-O-β-gentiobioside) | 54944-38-6 | Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside extracted from Cassia seeds. |
|
V99873 | COMT-IN-1 | 2987884-27-3 | COMT-IN-1 (Compound C12), a nitrophenol analog, is an orally active catechol-O-methyltransferase (COMT) inhibitor with IC50 of 0.37 μM, 95.58 μM, and 58.82 μM for COMT, MAO-A, and MAO-B, respectively. |
|
V70668 | Decaffeoylacteoside (Decaffeoylverbascoside; Verbasoside) | 61548-34-3 | Decaffeoylacteoside is an inhibitor (blocker/antagonist) of AChE/BChE/LOX with moderate activity. |
|
V70669 | Echitovenidine | 7222-35-7 | Echitovenidine is an alkaloid extracted from Alstonia yunnanensis. |
|
V70670 | ETAP | 2575731-47-2 | ETAP is an MAO-A and MAO-B inhibitor. |
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