The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69121 | 4′-Demethylnobiletin | 34810-62-3 | 4′-Demethylnobiletin is a biobioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling. |
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V85176 | 5,7-Dichlorokynurenic acid sodium (5,7-DCKA sodium) | 1184986-70-6 | |
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V85165 | 5-Iodowillardiine | 140187-25-3 | |
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V70389 | 6-Hydroxykynurenic acid (6-HKA) | 3778-29-8 | 6-Hydroxykynurenic acid (6-HKA) is an analogue of kynurenic acid (KYNA) and can be extracted from Ginkgo leaves. |
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V84793 | AChE-IN-53 | 2807436-94-6 | |
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V69998 | Alaproclate hydrochloride (GEA 654 hydrochloride; A03 hydrochloride) | 60719-83-7 | Alaproclate (GEA 654) HCl is a selective, orally bioactive serotonin reuptake inhibitor (SSRI). |
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V70425 | AMPA receptor modulator-2 | 2034181-36-5 | AMPA receptor modulator-2 (Example 134) is a modulator of AMPA receptors, with pIC50 of 10.1 for TARPγ2-dependent AMPA receptors. |
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V70438 | AMPA receptor modulator-4 | 2917551-59-6 | AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally bioavailable PAM (positive allosteric modulator) of the AMPA receptor (AMPAR PAM). |
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V70444 | AMPA receptor modulator-5 | 2034182-22-2 | AMPA receptor modulator-5 (Example 217) is an AMPA receptor modulator. |
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V70452 | AMPA receptor modulator-6 | 516491-33-1 | AMPA receptor modulator-6 (compound (R,R)-2b) is an AMPA receptor PAM (positive allosteric modulator) (AMPA receptor PAM). |
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V85440 | AMPA receptor modulator-7 | ||
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V104846 | Argiotoxin 636 | 105029-41-2 | Argiotoxin 636 is a toxin that is a nonspecific, noncompetitive and potent ionotropic glutamate receptor (iGluR) antagonist. |
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V70421 | ATPA | 140158-50-5 | ATPA is a selective glutamate receptor GluR5 activator for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L) and GluR5(S741V) The EC50 were 0.66, 9.5, 1.4, 23, 32, 18 and 14 μM respectively. |
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V3340 | ATPO | 252930-37-3 | ATPO is a novel, potent, selective and competitiveantagonist ofGluR1-4 (AMPA-preferring) receptors. |
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V87169 | AVLX-125 | 1786434-31-8 | AVLX-125 (UCCB01-125) is a PSD-95 and PDZ domain inhibitor with a Kd of 10 nM. |
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V87173 | BDZ-P7 | BDZ-P7 inhibits AMPA receptor GluA2, GluA1/2, GluA2/3, and GluA1 subunits with IC50s of 3.03 μM, 3.14 μM, 3.19 μM, and 3.2 μM, respectively. | |
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V70410 | BPAM344 | 1204572-55-3 | BPAM344 is a positive allosteric modulator (PAM) of the kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a. |
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V70442 | Bupivacaine hydrochloride monohydrate | 73360-54-0 | Bupivacaine HCl monohydrate is an NMDA receptor blocker/inhibitor. |
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V101376 | Caged MK801 | 217176-91-5 | Caged MK801 (cMK801) is a selective, noncompetitive, irreversible NMDA receptor open channel blocker. |
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V94209 | Caroverine | 23465-76-1 | Caroverine is a potent, competitive, and reversible NMDA and AMPA glutamate receptor antagonist. |
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