The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70438 | AMPA receptor modulator-4 | 2917551-59-6 | AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally bioavailable PAM (positive allosteric modulator) of the AMPA receptor (AMPAR PAM). |
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V70444 | AMPA receptor modulator-5 | 2034182-22-2 | AMPA receptor modulator-5 (Example 217) is an AMPA receptor modulator. |
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V70452 | AMPA receptor modulator-6 | 516491-33-1 | AMPA receptor modulator-6 (compound (R,R)-2b) is an AMPA receptor PAM (positive allosteric modulator) (AMPA receptor PAM). |
|
V85440 | AMPA receptor modulator-7 | ||
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V70421 | ATPA | 140158-50-5 | ATPA is a selective glutamate receptor GluR5 activator for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L) and GluR5(S741V) The EC50 were 0.66, 9.5, 1.4, 23, 32, 18 and 14 μM respectively. |
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V3340 | ATPO | 252930-37-3 | ATPO is a novel, potent, selective and competitiveantagonist ofGluR1-4 (AMPA-preferring) receptors. |
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V70410 | BPAM344 | 1204572-55-3 | BPAM344 is a positive allosteric modulator (PAM) of the kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a. |
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V17217 | Bupivacaine (SKY 0402) | 38396-39-3 | Bupivacaine (AH-250; HSDB 7790; SKY 0402) is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. |
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V70442 | Bupivacaine hydrochloride monohydrate | 73360-54-0 | Bupivacaine HCl monohydrate is an NMDA receptor blocker/inhibitor. |
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V18373 | CIQ | 486427-17-2 | CIQ is a novel, potent and GluN2C/GluN2D subunit-selective NMDA receptor potentiator, which reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. |
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V70468 | cis-ACPD | 477331-06-9 | cis-ACPD is a potent NMDA receptor agonist/activator with IC50 of 3.3 μM. |
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V70467 | Cl-HIBO | 909400-43-7 | Cl-HIBO is a highly isoform-selective GluR1/2 agonist (EC50 of 4.7 and 1.7 μM, respectively). |
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V18479 | CNQX Disodium | 479347-85-8 | CNQX Disodium (FG-9065), the disodium salt form of CNQX, is a potent AMPA/kainate antagonist with higherwater-solubility than the free acid formCNQX(Cat. |
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V4076 | Coluracetam | 135463-81-9 | Coluracetam (also known as MKC-231 and BCI-540) is a novel choline uptake enhancer. |
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V78852 | Conantokin G TFA | Conantokin G TFA is a 17 amino acid (AA) peptide that is a specific and competitive N-methyl-D-aspartate (NMDA) receptor antagonist. | |
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V70477 | Conantokin R (Con-R) | 202925-60-8 | Conantokin R (Con-R) is an NMDA receptor peptide antagonist (inhibitor) with IC50 of 93 nM. |
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V70484 | Conantokin-T | 127476-26-0 | Conantokin-T is an N-methyl-D-aspartate (NMDA) antagonist peptide containing γ-carboxyglutamate with IC50 of 2 μM. |
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V70449 | CP-465022 hydrochloride | 1785666-59-2 | CP-465022 HCl is a specific, noncompetitive AMPA receptor antagonist (inhibitor) with anticonvulsant (antiepileptic/antiseizure) activity. |
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V77135 | Crocetin meglumine (Transcrocetin meglumine; trans-Crocetin meglumine) | Crocetin (Transcrocetin) meglumine, found in saffron (Crocus sativus L.), is a high-affinity NMDA receptor antagonist. | |
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V18913 | CX546 | 215923-54-9 | CX546 is an AMPA receptor potentiator. |
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