The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V85190 | DL-AP5 sodium (2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium) | 1303993-72-7 | DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. |
|
V70458 | DL-AP7 (2-APH; 2-Amino-7-phosphonoheptanoic acid) | 85797-13-3 | DL-AP7 is a competitive NMDA antagonist and anticonvulsant (antiepileptic/antiseizure). |
|
V20240 | DQP-1105 | 380560-89-4 | DQP-1105 (DQP1105) is a novel, potent, non-competitive and negative allosteric modulator of the GluN2C/D NMDA receptor with potential to be used for Neuroscience applications. |
|
V70447 | DQP-26 | 1449373-99-2 | DQP-26 is a potent NAM (negative allosteric modulator) of NMDAR with IC50s of 0.77 μM and 0.44 μM for GluN2C and GluN2D, respectively. |
|
V70482 | Ensaculin free base (KA-672; Anseculin) | 155773-59-4 | Ensaculin free base (KA-672) is an NMDA antagonist (inhibitor) with high affinity for serotonergic 5-HT1A and 5-HT7 receptors, adrenergic α1, and dopaminergic D2 and D3 receptors. |
|
V3241 | Farampator (CX-691, Org24448) | 211735-76-1 | Farampator (also known as CX-691 or Org24448) is a positive and allosteric modulator of theAMPA (alpha-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid) receptor. |
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V70408 | Felbamate-d4 (felbamate d4) | 106817-52-1 | Felbamate-d4 is the deuterium labelled form of Felbamate. |
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V70450 | Felbamate-d5 (Felbamyl-d5; Felbatol-d5; Taloxa-d5) | 1191888-51-3 | Felbamate-d5 is the deuterium labelled form of Felbamate. |
|
V70462 | Fluoroethylnormemantine | 1639210-26-6 | Fluoroethylnormemantine is an analogue of Memantine and an antagonist of N-methyl-D-aspartate (NMDA) receptors. |
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V70423 | Fluoroethylnormemantine hydrochloride | 1639210-25-5 | Fluoroethylnormemantine HCl is an analogue of Memantine and an antagonist of N-methyl-D-aspartate (NMDA) receptors. |
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V94251 | Flupirtine hydrochloride | 33400-45-2 | Flupirtine hydrochloride (D 9998 hydrochloride) is a selective neural potassium channel opener with analgesic properties. |
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V70456 | Flupirtine-d4 hydrochloride (D 9998-d4 hydrochloride) | 1324717-75-0 | Flupirtine-d4 (D 9998-d4) HCl is the deuterated form of Flupirtine. |
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V94941 | Gacyclidine hydrochloride | 131774-33-9 | Gacyclidine hydrochloride is a noncompetitive N-methyl-D-aspartate (NMDA) antagonist that can be used in spinal cord injury research. |
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V96942 | gamma-DGG acetate | 2935387-13-4 | gamma-DGG acetate (γDGG acetate) is a competitive AMPA receptor blocker. |
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V104498 | gamma-DGG TFA | 71822-19-0 | Gamma-DGG TFA is an excitatory amino acid antagonist that blocks NMDA-, Kainate-, and Quisqualate-induced depolarizations and antagonizes excitatory postsynaptic potentials (EPSPs) in rat hippocampal slices. |
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V70459 | Gavestinel (GV 150526) | 153436-22-7 | Gavestinel (GV 150526) is a potent and selective NMDA receptor glycine site antagonist. |
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V70491 | GluN2B receptor modulator-1 | 2222010-71-9 | GluN2B receptor modulator-1 is a selective negative allosteric modulator (NAM) of GluN2B with IC50 of 31 nM. |
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V76971 | GluN2B-NMDAR antagonist-1 | GluN2B-NMDAR antagonist-1 is an orally bioactive GluN2B-NMDAR antagonist. | |
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V103511 | GluN2B-NMDAR antagonist-2 | GluN2B-NMDAR antagonist-2 (Compound S-58) is a potent, selective, blood-brain barrier-penetrating NMDAR-GluN2B antagonist with IC50 of 74.01 nM. | |
|
V4907 | GNE-8324 | 1698901-76-6 | GNE-8324 (GNE8324) is a novel, potent and selective PAM (Positive Allosteric Modulators) of NMDA receptor. |
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