The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V70491 | GluN2B receptor modulator-1 | 2222010-71-9 | GluN2B receptor modulator-1 is a selective negative allosteric modulator (NAM) of GluN2B with IC50 of 31 nM. |
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V76971 | GluN2B-NMDAR antagonist-1 | GluN2B-NMDAR antagonist-1 is an orally bioactive GluN2B-NMDAR antagonist. | |
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V4907 | GNE-8324 | 1698901-76-6 | GNE-8324 (GNE8324) is a novel, potent and selective PAM (Positive Allosteric Modulators) of NMDA receptor. |
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V70409 | GNE-9278 | 2315311-83-0 | GNE-9278 is a selective PAM (positive allosteric modulator) of NMDAR that acts on the GluN1 transmembrane domain (TMD). |
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V70385 | GYKI 52466 hydrochloride | 192065-56-8 | GYKI 52466 HCl is an orally bioactive, selective and noncompetitive AMPA/Kainate receptor antagonist (inhibitor) with IC50s of 7.5 and 11 μM respectively. |
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V70439 | Homoquinolinic acid | 490-75-5 | Homoquinolinic acid is a non-endogenous NMDAR2 receptor agonist (activator). |
![Ibotenic Acid [(RS)-Ibotenic acid; DL-Ibotenic acid]](http://www.invivochem.com/upload/0201/6374167693676059941396864166.png)
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V22375 | Ibotenic Acid [(RS)-Ibotenic acid; DL-Ibotenic acid] | 2552-55-8 | Ibotenic Acid [(RS)-Ibotenic acid; DL-Ibotenic acid] is a highly potent excitatory amino acid agonist with activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. |
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V2817 | IC-87201 | 866927-10-8 | IC87201 isan inhibitor of PSD95-nNOS protein-protein interactions. |
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V5255 | IDRA-21 | 22503-72-6 | IDRA-21 is a positive allosteric modulator (PAM) of the AMPA receptor and a benzothiadiazine derivative. |
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V31254 | Kynurenic acid sodium | 2439-02-3 | Kynurenic acid sodium is anendogenoustryptophan metabolite with activity against NMDA, glutamate, α7 nicotinic acetylcholine receptors. |
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V5033 | L-701324 | 142326-59-8 | L-701324 (L701324),a novel, potent and selective NMDA/glycine receptor antagonist, is an orally bioactive and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor. |
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V70451 | L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) | 79055-67-7 | L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist that is more potent than the isomer D-AP5. |
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V70393 | Lanicemine dihydrochloride (lanicemine dihydrochloride; AZD6765 dihydrochloride; ARL 15896AR) | 153322-06-6 | Lanicemine (AZD6765) di-HCl is a low-trapping NMDA receptor antagonist (inhibitor) with Ki of 0.56-2.1 μM. |
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V70436 | Leptin (116-130) | 189224-35-9 | Leptin (116-130) is a biologically active leptin fragment. |
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V70474 | LSP-GR3 | 1235945-37-5 | LSP-GR3 is a new type of chemically modified RNA oligonucleotide, called splice modulate oligomers (SMOs), which can specifically regulate GluR alternative splicing and Expression of GluR3-flip. |
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V80626 | LSP-GR3 sodium | LSP-GR3 sodium is a new type of chemically modified RNA oligonucleotide, called splice modulate oligomers (SMOs), which can specifically regulate the alternative splicing of GluR in the central nervous system/CNS and expression of GluR3-flip. | |
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V4851 | LY-3130481 | 1610802-47-5 | LY3130481 (also known as CERC-611) is a novel and potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist t that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, it selective inhibits AMPA/TARP γ-8 with anIC50of 65 nM. |
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V12017 | LY-404187 | 211311-95-4 | LY-404187 is an ampakine, AMPA receptor potentiator. |
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V80646 | LY836 | LY836 is an orally bioactive neuro-protection agent. | |
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V2929 | MDL-29951 | 130798-51-5 | MDL-29951 is a potent glycine antagonist of NMDA (N-methyl-D-aspartate) receptor activation with Kivalue of 0.14 μM in an in vitro and in vivo [3H]glycine binding assay. |
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