The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V26594 | Noopept | 157115-85-0 | Omberacetam (GVS-111) is a bioactive peptide available as a dietary supplement. |
|
V70440 | NPEC-caged-(S)-AMPA | 1257323-84-4 | NPEC-caged-(S)-AMPA is a caged neurotransmitter analogue that uses NPEC photoprotective groups to cage (S)-AMPA so that the caged ligand can react with glutamate. |
|
V87174 | NR2B-selective NMDA receptor antagonist 1 | 457897-92-6 | NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors with IC50 of 0.05 μM, 0.73 μM, and 2.4 μM for NR1/NR2B NMDA receptors, hERG, and α1-AdR, respectively. |
|
V70394 | NS-102 | 136623-01-3 | NS-102 is a selective kainate (GluK2) receptor blocker (antagonist). |
|
V70473 | NS1219 ((R)-SPD502) | 233603-81-1 | NS1219 ((R)-SPD502) is an isomer of NS 1209. |
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V70407 | NYX-2925 | 2012536-16-0 | NYX-2925 is an orally bioavailable NMDAR modulator. |
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V70466 | Oleoyl-D-lysine | 2240164-55-8 | Oleoyl-D-lysine is a lipid-based, selective inhibitor of glycine transporter-2 (GlyT2). |
|
V70429 | Onfasprodil | 1892581-29-1 | Onfasprodil is a NAM (negative allosteric modulator) of NR2B. |
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V70424 | Org-26576 | 100044-96-0 | Org-26576 is a positive allosteric modulator (PAM) of AMPA receptors. |
|
V103515 | Orphenadrine | 83-98-7 | Orphenadrine ((±)-orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also possesses antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic properties. |
|
V79048 | Orphenadrine-d3 citrate (orphenadrine d3 (citrate)) | Orphenadrine-d3 (citrate) is the deuterated form of Orphenadrine citrate. | |
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V70470 | Orphenadrine-d3 hydrochloride | 1309283-23-5 | Orphenadrine-d3 ( HCl) is the deuterated form of Orphenadrine HCl. |
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V70396 | Osavampator (TAK-653) | 1358751-06-0 | Osavampator (TAK-653) is a novel AMPA receptor-PAM (positive allosteric modulator). |
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V70460 | p-fin4 | 2883747-74-6 | p-fin4 is a bioactive peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with Ki of 0.4 μM. |
|
V81027 | p3Ysh-3 | p3Ysh-3 is a bioactive peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with Ki of 1.09 μM. | |
|
V70454 | PDZ1 Domain inhibitor peptide | 1315378-73-4 | PDZ1 Domain inhibitor peptide is a cyclic peptide that binds to the β-Ala lactam side chain linker and targets the PDZ1 domain of PSD-95. |
|
V81063 | PDZ1 Domain inhibitor peptide TFA | PDZ1 Domain inhibitor peptide TFA is a cyclic peptide that binds to the β-Ala lactam side chain linker and targets the PDZ1 domain of PSD-95. | |
|
V76650 | PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) | PEAQX (NVP-AAM077) tetrasodium hydrate is a specific, orally bioavailable NMDA antagonist (inhibitor) with IC50s of 270 nM and 29600 nM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. | |
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V32952 | PEPA | 141286-78-4 | PEPA is an allosteric modulator of AMPAR and can bind to the LBDs domain of GluA2o/GluA3o. |
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V89804 | Philanthotoxin 74 diTFA | 401601-12-5 | Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist with IC50 values of 263 nM and 296 nM for GluR3 and GluR1, respectively. |
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