The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V32240 | SDZ 220-581 hydrochloride | 179411-93-9 | SDZ 220-581 hydrochloride (SDZ220581; SDZ-220581) is a novel and competitive antagonist of NMDA glutamate receptor subtype (pKi= 7.7) with the potential to be used forParkinsons disease. |
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V18801 | SDZ-220-581 | 174575-17-8 | SDZ-220-581 (SDZ-220581; SDZ220581) is a novel and potent competitive antagonist of NMDA glutamate receptor subtype(pKi= 7.7) with the potential to be used forParkinsons disease. |
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V38653 | Sepimostat | 103926-64-3 | Desription: Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. |
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V2439 | Sepimostate mesilate | 103926-82-5 | Sepimostate mesilate(also known as FUT-187orTO 187) is aninhibitor used in therapy of pancreatitis, it inhibits the Ifenprodil binding with a Ki value of 27.7 µM. |
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V4073 | Sunifiram (DM-235) | 314728-85-3 | Sunifiram (also known as DM-235), a piperazine derived ampakine-like drug, has potent nootropic effects in animal studies with significantly higher potency than piracetam. |
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V2970 | SYM2206 | 173952-44-8 | SYM2206 is a potent, specific and non-competitive antagonist of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor) receptors with IC50 value of 2.8 μM. |
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V70401 | TAT-GluA2 3Y | 1404188-93-7 | TAT-GluA2 3Y is an interfering peptide that blocks long-term depression of glutamatergic synapses by disrupting AMPAR endocytosis. |
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V70405 | Tat-NR2Baa | 847829-41-8 | Tat-NR2BAA is the control peptide of Tat-NR2B9c and has no activity. |
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V81527 | Tat-NR2Baa TFA | Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c and has no activity. | |
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V70420 | TCN 213 | 556803-08-8 | TCN 213 is a selective, surmountable, glycine-dependent GluN1/GluN2A NMDAR antagonist (inhibitor) with IC50s of 0.55, 3.5, and 40 μM in the presence of 75, 750, and 7500 nM glycine, respectively. |
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V70030 | threo-Ifenprodil hemitartrate | 1312991-83-5 | threo Ifenprodil hemitartrate is a σ receptor agonist/activator with Kis of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. |
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V80134 | TP-050 | TP-050 is an orally bioactive and selective NMDAR agonist/activator with EC50s of 0.51 μM and 9.6 μM for GluN2A and GluN2D inhibition, respectively. | |
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V5274 | Traxoprodil (CP101,606) | 134234-12-1 | Traxoprodil (CP-101606, CP 98113, and CP101,606) is a novel, potent and selective NMDA (NR2B N-Methyl-D-Aspartate) antagonist with neuroprotective effects. |
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V70463 | UBP301 | 569371-10-4 | UBP301 is a potent and specific kainate receptor antagonist (inhibitor) with IC50 and Kds of 164 μM and 5.94 μM respectively. |
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V76392 | UBP301 hydrochloride | UBP301 HCl is a potent and specific kainate receptor antagonist (inhibitor) with IC50 and Kds of 164 μM and 5.94 μM respectively. | |
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V70399 | UBP316 (ACET) | 936095-50-0 | UBP316 (ACET) is a potent and specific kainate receptor GluK1 (GluR5) antagonist (inhibitor) with a Kb value of 1.4 nM. |
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V41861 | WAY-303290 | 323176-64-3 | GluR6 antagonist-1 is a benzothiophene analogue that works as a GluR6 antagonist. |
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V70417 | Withanone | 27570-38-3 | Withanone, the active ingredient from the root of Withania somnifera, has multifunctional neuro-protection effects in alleviating cognitive dysfunction. |
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V70446 | Withaphysalin D | 91599-21-2 | Withaphysalin D is a selective antagonist of GluN2B-containing N-methyl-d-aspartate receptors (NMDAR). |
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V86043 | ZCAN262 |
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