The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70404 | Zelquistinel (AGN-241751; GATE-251) | 2151842-64-5 | Zelquistinel (AGN-241751) is an N-methyl-D-aspartate (NMDA) receptor partial agonist indicated for treating depression, anxiety, and other related psychiatric disorders. |
|
V2963 | ZL006 | 1181226-02-7 | ZL006 is an efficient inhibitor of the nNOS/PSD-95 protein-protein interaction and showed great promise in cellular experiments and animal models of ischemic stroke and pain. |
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