The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V27543 | PhTx-74 diHCl | 1227301-51-0 | PhTx-74 HCl (Philanthotoxin 74;PhTx 74;PhTx74),the dihydrochloride salt ofPhTx-74, isananalogue of philanthotoxin-4,3,3 which is anaturally-occurring wasp venom toxin. |
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V70414 | Plazinemdor (CAD-9303) | 2378285-59-5 | Plazinemdor is a PAM (positive allosteric modulator) of N-methyl-D-aspartate (NMDA) receptors utilized in the research of psychiatric, neurological, neurodevelopmental disorders and neurological diseases. |
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V107812 | Pregn-5-en-3β-ol | 2862-58-0 | Pregn-5-en-3β-ol is a steroid compound. |
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V70469 | Pregnanolone sulfate (pyridinium) | 124107-39-7 | Pregnanolone sulfate pyridinium is an endogenous neurosteroid that can inhibit NMDA receptors and has neuro-protective (neuro-protection) effects. |
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V2968 | QNZ46 | 1237744-13-6 | QNZ46 is a novelnon-competitive andNR2C/NR2D-selective NMDA receptor antagonist with IC50 values of 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively. |
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V94234 | Rapastinel acetate | 491872-39-0 | Rapastinel acetate (GLYX-13 acetate) is an N-methyl-D-aspartate (NMDA) receptor modulator with long-acting antidepressant activity. |
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V96872 | Remacemide | 128298-28-2 | Remacemide (FPL 12924) is an orally active, noncompetitive, low-affinity NMDA receptor antagonist. |
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V70445 | Risevistinel (NYX-783) | 2591344-26-0 | Risevistinel (NYX-783) is a PAM (positive allosteric modulator) of the N-methyl-D-aspartate (NMDA) receptor. |
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V70478 | Ro 04-5595 hydrochloride | 64047-73-0 | Ro 04-5595 HCl is a GluN2B-selective NMDA receptor blocker (antagonist) (Ki= 31 nM). |
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V94827 | Ro 8-4304 | 195988-65-9 | Ro 8-4304 is a noncompetitive, voltage-independent and state-dependent NMDA receptor antagonist. |
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V70487 | SDZ 220-040 | 174575-40-7 | SDZ 220-040 is a competitive mammalian NMDA receptor blocker (antagonist). |
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V32239 | SDZ 220-581 Ammonium salt | 179411-94-0 | SDZ 220-581 Ammonium salt (SDZ-220581; SDZ220581) is a novel and competitive antagonist of NMDA glutamate receptor subtype (pKi= 7.7) with the potential to be used forParkinsons disease. |
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V32240 | SDZ 220-581 hydrochloride | 179411-93-9 | SDZ 220-581 hydrochloride (SDZ220581; SDZ-220581) is a novel and competitive antagonist of NMDA glutamate receptor subtype (pKi= 7.7) with the potential to be used forParkinsons disease. |
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V18801 | SDZ-220-581 | 174575-17-8 | SDZ-220-581 (SDZ-220581; SDZ220581) is a novel and potent competitive antagonist of NMDA glutamate receptor subtype(pKi= 7.7) with the potential to be used forParkinsons disease. |
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V104224 | SN-35210 free base | 1450615-41-4 | SN-35210 (free base) is a ketamine ester analog that is rapidly eliminated by esterase-mediated hydrolysis. |
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V95435 | SPD-502 sodium | 205645-02-9 | SPD-502 sodium is a glutamate antagonist with potential neuroprotective effects, especially in cerebral ischemia. |
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V2970 | SYM2206 | 173952-44-8 | SYM2206 is a potent, specific and non-competitive antagonist of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor) receptors with IC50 value of 2.8 μM. |
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V87172 | TAT-CBD3 | 1355359-36-2 | TAT-CBD3, a 15-amino acid peptide from CRMP2 fused to the TAT cell-penetrating sequence of the HIV-1 protein, disrupts the CRMP2-NMDAR interaction without altering NMDAR localization. |
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V70401 | TAT-GluA2 3Y | 1404188-93-7 | TAT-GluA2 3Y is an interfering peptide that blocks long-term depression of glutamatergic synapses by disrupting AMPAR endocytosis. |
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V70405 | Tat-NR2Baa | 847829-41-8 | Tat-NR2BAA is the control peptide of Tat-NR2B9c and has no activity. |
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