Nicotinic acetylcholine receptors, or nAChRs, are proteins on neurons that signal when a chemical stimulus causes muscles to contract. On the presynaptic and postsynaptic sides of the neuromuscular junction, as well as in the plasma membranes of some neurons, they are cholinergic receptors that create ligand-gated ion channels. The most extensively researched ionotropic receptors are those for nicotinic acetylcholine. The neurotransmitter acetylcholine (ACh) binds to the nAChR, just like it does with the other type of acetylcholine receptor, the muscarinic acetylcholine receptor (mAChR). Nicotinic receptors can be opened by both acetylcholine and nicotine, hence the name "nicotinic," just as muscarinic receptors are so named because they are also activated by muscarine.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70772 | RGH-560 | 2408799-43-7 | RGH-560(53) displays a high degree of α7 nAChR positive modulator activity and favorable physicochemical characteristics. |
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V76553 | Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) | Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) is a neuronal nicotinic receptor agonist/activator with high selectivity for the α4β2 subtype, with a Ki of 26 nM and a Ki of 26 nM for the α7 receptor. | |
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V70762 | RJR-2429 dihydrochloride | 1021418-53-0 | RJR-2429 (diHCl) is an α4β2 and α7 nAChR agonist. |
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V2474 | SEN-12333 | 874450-44-9 | SEN 12333（also known as WAY-31753）, is a novel,potent and selective agonist of the alpha(7) nAChR (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). |
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V70778 | SIB-1508Y | 192231-16-6 | SIB-1508Y is an orally bioactive, selective nAChR agonist. |
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V4414 | Sofiniclin | 799279-80-4 | Sofiniclin (formerly also known as ABT-894 and A-422894) is a novel and potent agonist ofnicotinic acetylcholine receptor (nAChR) which isused as a potential non-stimulant treatment for attention-deficit/hyperactivity disorder (ADHD). |
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V70701 | Spinosad (spinosad) | 168316-95-8 | Spinosad is a bioneurotoxic insecticide with a broader spectrum of action, a blend of spinosyns A and D, which is a fermentation product of soil actinomycetes. |
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V70780 | SR 16584 | 1150153-86-8 | SR16584 is a selective antagonist of α3β4 nAChR with IC50 of 10.2 μM. |
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V2189 | SUVN-911 | 2414674-71-6 | SUVN-911 is a novel, potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. |
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V70779 | TC-1698 | 700834-58-8 | TC-1698 is a selective α7 nicotinic acetylcholine receptor agonist, with EC50s of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. |
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V70726 | TC-2559 diffuse | 2454492-41-0 | TC-2559 difumarate is a CNS-selective, orally bioactive partial agonist of the nicotinic acetylcholine receptor (nAChR) α4β2 subtype. |
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V85421 | Tebanicline (Ebanicline; ABT-594) | 198283-73-7 | |
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V70713 | Tebanicline dihydrochloride (Ebanicline dihydrochloride; ABT-594 dihydrochloride) | 209326-19-2 | Tebanicline di-HCl (Ebanicline di-HCl) is a modulator of nAChR with potent oral analgesic activity. |
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V5315 | TMPH inhibitor | 849461-90-1 | nAChR-IN-1 (2,2,6,6-Tetramethylpiperidin-4-yl heptanoate) is a tetramethylpiperidinyl enanthate and a selective nicotinic acetylcholine receptor (nAChR) inhibitor. |
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V70705 | TQS | 353483-92-8 | TQS is a PAM (positive allosteric modulator) of the α7 nicotinic acetylcholine receptor (nAChR). |
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V70742 | UB-165 | 200432-86-6 | UB-165 is an agonist of nAChR, a full agonist of α3β2 subtype, and a partial agonist of α4β2* subtype. |
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V70721 | UB-165 fumarate | 2454492-43-2 | UB-165 fumarate is an agonist of nAChR, a full agonist of α3β2 subtype, and a partial agonist of α4β2* subtype. |
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V5321 | Varenicline | 249296-44-4 | Varenicline (also known as CP 526555),an approved medication used to treat nicotine addiction, is a potent and selective α4β2 nicotinic receptor (nAChR) partial agonist. |
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V2410 | Varenicline dihydrochloride | 866823-63-4 | Varenicline dihydrochlorideis a nicotinic receptor partial agonist. |
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V80242 | Varenicline-d4 dihydrochloride (varenicline dihydrochloride-d4) | Varenicline-d4 (di-HCl) is the deuterated form of Varenicline di-HCl. |
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