Seven cation permeable ligand-gated ion channels (LGICs) known as P2X receptors (P2X1R-P2X7R) are a family of LGICs that open in response to the extracellular ligand adenosine 5′-triphosphate (ATP) binding. P2X receptors are widely expressed in the nervous, immune, cardiovascular, skeletal, gastrointestinal, respiratory, and endocrine systems and have a high permeability to Ca2+, Na+, and K+.
P2X receptors are extensively expressed in both excitatory and non-excitatory cells, including neuron, glia, platelet, epithelia, and macrophages. They play a key role in a number of critical physiological and pathological processes, such as synaptic transmission, pain perception, inflammation, cardiovascular regulation, immune modulation, and tumorigenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V87210 | P2X4 antagonist-2 | 2055601-24-4 | P2X4 antagonist-2 is a P2X4 antagonist with IC50 of 24 nM. |
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V73567 | P2X7 receptor antagonist-3 | 1627900-92-8 | P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist (inhibitor) with P2X7R IC50s of 4.2 nM and 6.8 nM in humans and rats respectively. |
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V94394 | P2X7 receptor antagonist-5 | 3046388-16-0 | P2X7 receptor antagonist-5 (compound 13a) is a potent, orally active and long-lasting P2X7 receptor antagonist. |
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V88981 | PPADS | 149017-66-3 | PPADS is a P2 receptor antagonist with IC50 of 68 nM (P2X1) and 214 nM (P2X3). |
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V73576 | Purotoxin 1 | 1396322-38-5 | Purotoxin 1 is a P2X3 receptor blocker/inhibitor. |
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V93696 | Relicpixant | 2445366-94-7 | Relicpixant is a potent purinergic receptor (P2X) antagonist. |
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V3327 | RO-3 | 1026582-88-6 | RO-3 is potent, selective, orally active and brain penetrant antagonist of homomeric P2X3and heteromeric P2X2/3receptor with pIC50values are 7.0 and 5.9 respectively. |
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V73579 | Ro-51 | 1050670-85-3 | Ro-51 is a highly efficient and selective P2X3/P2X2/3 dual antagonist, with IC50s of 2 nM and 5 nM for P2X3 and P2X2/3 respectively. |
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V73564 | Sivopixant (S-600918) | 2414285-40-6 | Sivopixant (S-600918) is a potent and specific P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). |
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V87211 | Uridine adenosine tetraphosphate | 10527-48-7 | Uridine adenosine tetraphosphate (UP4A) is an endothelium-derived vasoconstrictor that primarily acts through the P2X1 receptor and may also act through the P2Y2 and P2Y4 receptors. |
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V73577 | α,β-Methylene-ATP | 7292-42-4 | α,β-Methylene ATP is a phosphonate analog of ATP and a ligand for P2X3 and P2X7 receptors. |
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V73566 | α,β-Methylene-ATP dilithium | 104809-20-3 | α,β-Methylene ATP dilithium is a phosphonate analog of ATP and a ligand for P2X3 and P2X7 receptors. |
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V73558 | α,β-Methylene-ATP trisodium | 1343364-54-4 | α,β-Methylene-ATP trisodium is a phosphonate analog of ATP and a ligand for P2X3 and P2X7 receptors. |
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V2116 | Gefapixant (AF219; MK-7264) | 1015787-98-0 | Gefapixant (also known as AF-219 and MK-7264) is a novel, potent, and orally bioactive P2X3 receptor (P2X3R) antagonist with antitussive effects, and may be used forchronic cough. |
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