Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84295 | KCNK13-IN-1 | 361368-24-3 | |
|
V85517 | KIO-301 chloride | 1643463-59-5 | |
|
V1682 | KPT-185 | 1333151-73-7 | This product has been discontinued. |
|
V80519 | KTX-Sp2 | KTX-Sp2 is a potassium channel toxin. | |
|
V80521 | KV1.3-IN-1 | KV1.3-IN-1 (Compound trans-18) is a KV1.3 channel inhibitor (IC50= 230 nM and 26.12 nM in Ltk? cells and PHA-activated T lymphocytes, respectively). | |
|
V85080 | Kv2.1-IN-1 | 2252448-93-2 | |
|
V73616 | Kv3 modulator 5 | 1380696-68-3 | Kv3 modulator 5 (Example 5) is a Kv3 channel modulator. |
|
V73656 | Lei-Dab7 | 1061556-49-7 | Lei-Dab7 is a potent and specific SK2 (KCa2.2) channel blocker with a Kd of 3.8 nM. |
|
V80552 | Lei-Dab7 TFA | Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). | |
|
V3780 | LY303511 | 154447-38-8 | LY303511 is an analog ofLY294002and is also known as NV-128 and EM 101. |
|
V80686 | Margatoxin TFA | Margatoxin TFA is an α-KTx scorpion toxin, a high-affinity Kv1.3 inhibitor (antagonist) with a Kd of 11.7 pM. | |
|
V73627 | Maurotoxin | 188240-41-7 | Maurotoxin is a toxin consisting of 34 residues and 4 disulfide bridges that can be extracted from the chactoid scorpion (Scorpio maurus). |
|
V25309 | Mesoridazine free base | 5588-33-0 | Mesoridazine is a potent phenothiazine dopamine receptor anatagonist that is able to inhibit D2DR and D4DR. |
|
V12383 | Minoxidil | 38304-91-5 | Minoxidil (U-10858; Loniten; Rogaine)is anantihypertensive agentand vasodilatorthat has also found usefulness in treatment of hair loss andalopecia areatawhenapplied topically. |
|
V73587 | Minoxidil sulfate | 83701-22-8 | Minoxidil sulfate is a potent ATP-sensitive K+ channel agonist and the sulfate metabolite of minoxidil. |
|
V73599 | Minoxidil-d10 (minoxidil-d10) | 1020718-66-4 | Minoxidil-d10 is the deuterium labelled form of Minoxidil. |
|
V1679 | Mitiglinide Calcium (KAD-1229) | 145525-41-3 | Mitiglinide Calcium (formerlyKAD-1229; S-21403; KAD1229; S21403;Glufast), the calcium salt ofMitiglinide, is a potassiun channel blocker that has been approved asa blood glucose-lowering drug for the treatment of type 2 diabetes. |
|
V79950 | Mitiglinide-d8 calcium hydrate | Mitiglinide-d8 (calcium hydrate) is the deuterated form of Mitiglinide calcium hydrate. | |
|
V4305 | MK-7145 | 1255204-84-2 | MK-7145 is a novel, potent, selective and orally bioactive ROMKinhibitor with IC50of 0.045 μM and has the potential for the treatment of hypertension and heart failure. |
|
V73608 | MK-8153 | 1548286-45-8 | MK-8153 is a specific and orally bioactive renal outer medullary potassium channel (ROMK) inhibitor (antagonist) with IC50s of 5 nM and 34 μM for ROMK EP and hERG EP, respectively. |
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